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Efemp2 epidermal growth factor-containing fibulin-like extracellular matrix protein 2 [ Mus musculus (house mouse) ]

Gene ID: 58859, updated on 19-Jul-2014
Official Symbol
Efemp2provided by MGI
Official Full Name
epidermal growth factor-containing fibulin-like extracellular matrix protein 2provided by MGI
Primary source
MGI:1891209
See related
Ensembl:ENSMUSG00000024909; Vega:OTTMUSG00000036759
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MBP1; Fbln4; 0610011K11Rik
See Efemp2 in Epigenomics, MapViewer
Location:
19 A; 19
Exon count:
14
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 19 NC_000085.6 (5473960..5481854)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor (acidic) intracellular binding protein Neighboring gene cathepsin W Neighboring gene MUS81 endonuclease homolog (yeast) Neighboring gene cofilin 1, non-muscle

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
blood coagulation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
proteinaceous extracellular matrix TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
EGF-containing fibulin-like extracellular matrix protein 2
Names
EGF-containing fibulin-like extracellular matrix protein 2
FIBL-4
fibulin 4
fibulin-4
mutant p53-binding protein 1
EGF-containing fibulin-like extracellular matrix protein 2 (Efemp2)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164352.1NP_001157824.1  EGF-containing fibulin-like extracellular matrix protein 2 isoform 2 precursor

    See proteins identical to NP_001157824.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) retains a segment in its 5' end which results in the use of an upstream start codon, compared to variant 1. The resulting protein (isoform 2) has a longer N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AI327154, AK075585, CJ093169
    Consensus CDS
    CCDS50358.1
    UniProtKB/TrEMBL
    G5E8D6
    UniProtKB/TrEMBL
    Q542X5
    Related
    ENSMUSP00000064719, OTTMUSP00000052424, ENSMUST00000070118, OTTMUST00000094317
    Conserved Domains (4) summary
    smart00179
    Location:183216
    Blast Score: 100
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:142182
    Blast Score: 103
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cl00057
    Location:217257
    Blast Score: 92
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl09941
    Location:302329
    Blast Score: 88
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  2. NM_021474.3NP_067449.3  EGF-containing fibulin-like extracellular matrix protein 2 isoform 1 precursor

    See proteins identical to NP_067449.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the more frequently occurring transcript.
    Source sequence(s)
    AI327154, AK075585, BY234446
    Consensus CDS
    CCDS29466.1
    UniProtKB/TrEMBL
    Q542X5
    UniProtKB/Swiss-Prot
    Q9WVJ9
    Related
    ENSMUSP00000133016, OTTMUSP00000052420, ENSMUST00000165485, OTTMUST00000094312
    Conserved Domains (4) summary
    smart00179
    Location:164197
    Blast Score: 99
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:123163
    Blast Score: 102
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cl00057
    Location:198238
    Blast Score: 92
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl09941
    Location:283310
    Blast Score: 87
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000085.6 

    Range
    5473960..5481854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531807.1XP_006531870.1  

    Conserved Domains (4) summary
    smart00179
    Location:166199
    Blast Score: 100
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:125165
    Blast Score: 102
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cl00057
    Location:200240
    Blast Score: 92
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl09941
    Location:285312
    Blast Score: 88
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  2. XM_006531808.1XP_006531871.1  

    See proteins identical to XP_006531871.1

    UniProtKB/TrEMBL
    Q542X5
    UniProtKB/Swiss-Prot
    Q9WVJ9
    Conserved Domains (4) summary
    smart00179
    Location:164197
    Blast Score: 99
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:123163
    Blast Score: 102
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cl00057
    Location:198238
    Blast Score: 92
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl09941
    Location:283310
    Blast Score: 87
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  3. XM_006531809.1XP_006531872.1  

    Conserved Domains (4) summary
    smart00179
    Location:142175
    Blast Score: 99
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:101141
    Blast Score: 102
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cl00057
    Location:176216
    Blast Score: 92
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl09941
    Location:261288
    Blast Score: 87
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  4. XM_006531806.1XP_006531869.1  

    Conserved Domains (4) summary
    smart00179
    Location:176209
    Blast Score: 100
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:135175
    Blast Score: 103
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cl00057
    Location:210250
    Blast Score: 92
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl09941
    Location:295322
    Blast Score: 88
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  5. XM_006531811.1XP_006531874.1  

    Conserved Domains (4) summary
    smart00179
    Location:183216
    Blast Score: 93
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:142182
    Blast Score: 95
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam12662
    Location:202225
    Blast Score: 95
    cEGF; Complement Clr-like EGF-like
    cl00057
    Location:217257
    Blast Score: 92
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  6. XM_006531810.1XP_006531873.1  

    Conserved Domains (4) summary
    smart00179
    Location:96129
    Blast Score: 99
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:5595
    Blast Score: 102
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cl00057
    Location:130170
    Blast Score: 92
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl09941
    Location:215242
    Blast Score: 88
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

Alternate Mm_Celera

Genomic

  1. AC_000041.1 

    Range
    5346431..5353554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)