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Txnrd1 thioredoxin reductase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 58819, updated on 17-May-2016
Official Symbol
Txnrd1provided by RGD
Official Full Name
thioredoxin reductase 1provided by RGD
Primary source
RGD:61959
See related
Ensembl:ENSRNOG00000009088
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Tr
Summary
This gene encodes a member of the family of pyridine nucleotide-disulfide oxidoreductases. This protein is a flavoenzyme, which uses NADPH for reduction of thioredoxins as well as other protein and nonprotein substrates, and plays a role in protection against oxidative stress. It contains a selenocysteine (Sec) residue, which is essential for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Jul 2008]
Orthologs
Location:
7q13
Exon count:
15
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (26946124..26984400, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (27065819..27104095, complement)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene vegetative cell wall protein gp1-like Neighboring gene solute carrier family 41 member 2 Neighboring gene carbohydrate (chondroitin 4) sulfotransferase 11 Neighboring gene uncharacterized LOC103692813 Neighboring gene uncharacterized LOC103692814 Neighboring gene EP300 interacting inhibitor of differentiation 3 Neighboring gene uncharacterized LOC103692815 Neighboring gene nuclear transcription factor Y subunit beta

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC93353

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NAD(P)H oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
mercury ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
selenate reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
thioredoxin-disulfide reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
thioredoxin-disulfide reductase activity IEA
Inferred from Electronic Annotation
more info
 
thioredoxin-disulfide reductase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
NADPH oxidation IDA
Inferred from Direct Assay
more info
PubMed 
benzene-containing compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular response to copper ion IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to hyperoxia IEP
Inferred from Expression Pattern
more info
PubMed 
gastrulation ISO
Inferred from Sequence Orthology
more info
 
glutathione metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
halogen metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
hydrogen peroxide catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesoderm formation IEA
Inferred from Electronic Annotation
more info
 
mesoderm formation ISO
Inferred from Sequence Orthology
more info
 
methylmercury metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
placenta development IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tetramerization IDA
Inferred from Direct Assay
more info
PubMed 
response to axon injury IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to hyperoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
response to selenium ion IEP
Inferred from Expression Pattern
more info
PubMed 
selenocysteine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
thioredoxin reductase 1, cytoplasmic
Names
NADPH-dependent thioredoxin reductase
selenoprotein oxidoreductase
thioredoxin reductase TR1
NP_113802.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031614.2NP_113802.2  thioredoxin reductase 1, cytoplasmic

    Status: REVIEWED

    Source sequence(s)
    AA955679, BC085726
    UniProtKB/Swiss-Prot
    O89049
    Related
    ENSRNOP00000013612, ENSRNOT00000013613
    Conserved Domains (4) summary
    pfam00070
    Location:192268
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:370482
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
    TIGR01438
    Location:11499
    TGR; thioredoxin and glutathione reductase selenoprotein
    cl21454
    Location:151222
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    26946124..26984400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000075.1 Alternate Rn_Celera

    Range
    18009974..18048177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)