Mlxipl MLX interacting protein-like [Mus musculus] - Gene

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Summary

Official Symbol: Mlxiplprovided by MGI
Official Full Name: MLX interacting protein-likeprovided by MGI
Primary source: MGI:1927999
See related: Ensembl:ENSMUSG00000005373; Vega:OTTMUSG00000025974
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ChREBP; WS-bHLH; Wbscr14; bHLHd14

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Genomic context

Location :: 5 G2; 5

Sequence :: Chromosome: 5; NC_000071.6 (135106891..135138382)

See Mlxipl in Epigenomics, MapViewer

Chromosome 5 - NC_000071.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

an important mechanism by which importin-alpha and 14-3-3 control movement of ChREBP in and out of the nucleus in response to changes in glucose levels in liver
Title: Importin-alpha protein binding to a nuclear localization signal of carbohydrate response element-binding protein (ChREBP).
in liver, adiponutrin/PNPLA3 gene expression is under the direct transcriptional control of ChREBP (carbohydrate-response element-binding protein) and SREBP1c (sterol regulatory element binding protein1c) in response to glucose and insulin, respectively
Title: Distinct regulation of adiponutrin/PNPLA3 gene expression by the transcription factors ChREBP and SREBP1c in mouse and human hepatocytes.
ChREBP was unexpectedly required during fasting for maximal Rgs16 transcription in liver and in cultured primary hepatocytes during gluconeogenesis.
Title: Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner.
Results reveal that O-GlcNAcylation represents an important novel regulation of ChREBP activity in the liver under both physiological and pathophysiological conditions.
Title: O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver.
ChREBP is a critical and direct mediator of glucose repression of PPARalpha gene expression in pancreatic beta-cells
Title: ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells.
Carbohydrate response element-binding protein (ChREBP), a glucose-dependent transcription factor downstream of Protein phosphatase 2A, partially mediated the effects of glucose on metabolic markers.
Title: Gene regulation mediating fiber-type transformation in skeletal muscle cells is partly glucose- and ChREBP-dependent.
The db/db mouse exhibits significantly higher liver ChREBP activity, which may be associated with the development of hepatic steatosis frequently occurring in type 2 diabetes.
Title: [Role of increased activity of carbohydrate response element binding protein in excessive lipid accumulation in the liver of type 2 diabetic db/db mouse].
Data showed that the steatosis is accompanied by altered expression of a number of genes, including increased expression of ChREBP, which acts as one of the central determinants of lipid synthesis in the liver.
Title: Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition.
low SIK2 activity was associated with increased p300 HAT activity, ChREBP hyperacetylation, and hepatic steatosis
Title: Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice.
ChREBP is an attractive target to alleviate derangements in lipid metabolism observed in patients with glycogen storage disease.
Title: Carbohydrate-response-element-binding protein (ChREBP) and not the liver X receptor α (LXRα) mediates elevated hepatic lipogenic gene expression in a mouse model of glycogen storage disease type 1.

Submit: New GeneRIF Correction See all (30)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:208443	BioGRID:112805	MLX	BioGRID	PubMed	Two-hybrid
BioGRID:208443	BioGRID:121922	NIF3L1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:208443	BioGRID:223870	Ogt	BioGRID	PubMed	Affinity Capture-Western
BioGRID:208443	BioGRID:113361	YWHAB	BioGRID	PubMed	Two-hybrid
BioGRID:208443	BioGRID:116168	YWHAQ	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:208443	BioGRID:113366	YWHAZ	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
contributes_to DNA binding	IDA Inferred from Direct Assay more info	PubMed
carbohydrate response element binding	TAS Traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
transcription factor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
glucose mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell cycle arrest	ISO Inferred from Sequence Orthology more info
negative regulation of oxidative phosphorylation	ISO Inferred from Sequence Orthology more info
negative regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of glycolysis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of glycolysis	ISO Inferred from Sequence Orthology more info
positive regulation of lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
transcription factor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: carbohydrate-responsive element-binding protein

Names: carbohydrate-responsive element-binding protein; MLX interactor; MLX-interacting protein-like; MLX interacting protein-like beta; putative hepatic transcription factor; Williams-Beuren syndrome chromosome region 14 homolog

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021455.4 → NP_067430.2 carbohydrate-responsive element-binding protein

Status: VALIDATED

Source sequence(s)

AC024607, AF245475, BC064053, DV660420

Consensus CDS

CCDS39316.1

UniProtKB/Swiss-Prot

Q99MZ3

Related

ENSMUSP00000005507, OTTMUSP00000031771, ENSMUST00000005507, OTTMUST00000064065

Conserved Domains (1) summary

cd00083
Location:660 – 712
Blast Score: 132

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000071.6 Reference GRCm38 C57BL/6J

Range

135106891..135138382

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000027.1 Alternate Mm_Celera

Range

132118085..132149576

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC024607.3 (22340..57250)	None	C57BL/6J
genomic	CH466529.2	EDL19382.1	mixed
		EDL19383.1	mixed
		EDL19384.1	mixed
		EDL19385.1	mixed
mRNA	AF156604.1	AAF68175.1
mRNA	AF245475.1	AAK20940.1
mRNA	AF245476.1	AAK20941.1
mRNA	AF245477.1	AAK20942.1
mRNA	AF245478.1	AAK20943.1
mRNA	AF245479.1	AAK20944.1
mRNA	AK143800.1	None	C57BL/6J
mRNA	AK143999.1	BAE25657.1	C57BL/6J
mRNA	BC064053.1	None	C57BL/6J
mRNA	DV660420.1	None	C57BL/6J
mRNA	JQ437838.1	AFG29503.1	FVB
other-genetic	BC167240.1	AAI67240.1