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RABGGTA Rab geranylgeranyltransferase alpha subunit [ Homo sapiens (human) ]

Gene ID: 5875, updated on 8-May-2016
Official Symbol
RABGGTAprovided by HGNC
Official Full Name
Rab geranylgeranyltransferase alpha subunitprovided by HGNC
Primary source
HGNC:HGNC:9795
See related
Ensembl:ENSG00000100949 HPRD:03547; MIM:601905; Vega:OTTHUMG00000171838
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTAR3
Orthologs
Location:
14q11.2
Exon count:
16
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (24265538..24271627, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24734744..24740833, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene guanosine monophosphate reductase 2 Neighboring gene TERF1 interacting nuclear factor 2 Neighboring gene transglutaminase 1 Neighboring gene uncharacterized LOC102725044 Neighboring gene dehydrogenase/reductase (SDR family) member 1 Neighboring gene NOP9 nucleolar protein Neighboring gene cell death-inducing DFFA-like effector b

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rab GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Rab geranylgeranyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
protein geranylgeranylation IBA
Inferred from Biological aspect of Ancestor
more info
 
protein geranylgeranylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of apoptotic process TAS
Traceable Author Statement
more info
 
visual perception TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Rab-protein geranylgeranyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Rab-protein geranylgeranyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
geranylgeranyl transferase type-2 subunit alpha
Names
Rab GG transferase alpha
Rab GGTase alpha
Rab geranylgeranyltransferase, alpha subunit
geranylgeranyl transferase type II subunit alpha
protein prenyltransferase alpha subunit repeat containing 3
rab geranyl-geranyltransferase subunit alpha
NP_004572.3
NP_878256.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004581.5NP_004572.3  geranylgeranyl transferase type-2 subunit alpha

    See identical proteins and their annotated locations for NP_004572.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK292613, BC003093, DA379718, DB116988
    Consensus CDS
    CCDS45088.1
    UniProtKB/Swiss-Prot
    Q92696
    Related
    ENSP00000382341, OTTHUMP00000246915, ENST00000399409, OTTHUMT00000415308
    Conserved Domains (5) summary
    pfam07711
    Location:243345
    RabGGT_insert; Rab geranylgeranyl transferase alpha-subunit, insert domain
    pfam01239
    Location:92121
    PPTA; Protein prenyltransferase alpha subunit repeat
    pfam12799
    Location:466506
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:488545
    LRR_8; Leucine rich repeat
    sd00031
    Location:443461
    LRR_1; leucine-rich repeat [structural motif]
  2. NM_182836.2NP_878256.1  geranylgeranyl transferase type-2 subunit alpha

    See identical proteins and their annotated locations for NP_878256.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC003093, DA379718
    Consensus CDS
    CCDS45088.1
    UniProtKB/Swiss-Prot
    Q92696
    Related
    ENSP00000216840, OTTHUMP00000246918, ENST00000216840, OTTHUMT00000415311
    Conserved Domains (5) summary
    pfam07711
    Location:243345
    RabGGT_insert; Rab geranylgeranyl transferase alpha-subunit, insert domain
    pfam01239
    Location:92121
    PPTA; Protein prenyltransferase alpha subunit repeat
    pfam12799
    Location:466506
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:488545
    LRR_8; Leucine rich repeat
    sd00031
    Location:443461
    LRR_1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

    Range
    24265538..24271627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267960.1XP_005268017.1  

    See identical proteins and their annotated locations for XP_005268017.1

    UniProtKB/TrEMBL
    D3DS70
    Conserved Domains (4) summary
    pfam07711
    Location:175
    RabGGT_insert; Rab geranylgeranyl transferase alpha-subunit, insert domain
    pfam12799
    Location:218257
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:218275
    LRR_8; Leucine rich repeat
    sd00031
    Location:173191
    LRR_1; leucine-rich repeat [structural motif]
  2. XM_011537046.1XP_011535348.1  

    See identical proteins and their annotated locations for XP_011535348.1

    UniProtKB/Swiss-Prot
    Q92696
    Conserved Domains (5) summary
    pfam07711
    Location:243345
    RabGGT_insert; Rab geranylgeranyl transferase alpha-subunit, insert domain
    pfam01239
    Location:92121
    PPTA; Protein prenyltransferase alpha subunit repeat
    pfam12799
    Location:466506
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:488545
    LRR_8; Leucine rich repeat
    sd00031
    Location:443461
    LRR_1; leucine-rich repeat [structural motif]
  3. XM_005267959.2XP_005268016.1  

    See identical proteins and their annotated locations for XP_005268016.1

    UniProtKB/TrEMBL
    D3DS70
    Conserved Domains (4) summary
    pfam07711
    Location:175
    RabGGT_insert; Rab geranylgeranyl transferase alpha-subunit, insert domain
    pfam12799
    Location:218257
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:218275
    LRR_8; Leucine rich repeat
    sd00031
    Location:173191
    LRR_1; leucine-rich repeat [structural motif]

RNA

  1. XR_943502.1 RNA Sequence

    Related
    ENST00000559974, OTTHUMT00000415316

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    24733345..24739434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)