These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
mRNA and Protein(s)
-
NM_001258374.1 → NP_001245303.1 epidermal growth factor receptor substrate 15-like 1 isoform 1
Status: VALIDATED
- Description
- Transcript Variant: This variant (1) encodes the longest isoform (1).
- Source sequence(s)
-
AU121887, BC067114, CA311813, DC416977
-
NM_001258375.1 → NP_001245304.1 epidermal growth factor receptor substrate 15-like 1 isoform 3
Status: VALIDATED
- Description
- Transcript Variant: This variant (3) differs in the 3' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
- Source sequence(s)
-
AK024166, BC131590, BU075732, DC416977
-
NM_001258376.1 → NP_001245305.1 epidermal growth factor receptor substrate 15-like 1 isoform 4
Status: VALIDATED
- Description
- Transcript Variant: This variant (4) differs in the 3' UTR, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
- Source sequence(s)
-
AC020917, AU121887, BC142716, CA446537, DC416977
-
NM_021235.2 → NP_067058.1 epidermal growth factor receptor substrate 15-like 1 isoform 2
Status: VALIDATED
- Description
- Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
- Source sequence(s)
-
AF110265, AU121887, BU075732, DC416977
- Consensus CDS
-
CCDS32944.1
- UniProtKB/Swiss-Prot
-
Q9UBC2
- Related
- ENSP00000248070, ENST00000248070
- Conserved Domains (4) summary
-
- cd00052
Location:131 – 196
Blast Score: 218
- EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
- cd00176
Location:385 – 572
Blast Score: 118
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- smart00027
Location:268 – 364
Blast Score: 318
- EH; Eps15 homology domain
- pfam13870
Location:384 – 563
Blast Score: 100
- DUF4201; Domain of unknown function (DUF4201)
RNA
-
NR_047665.1 RNA Sequence
- Description
- Transcript Variant: This variant (5) lacks an internal exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AU121887, BC051873, CA311813, DC416977
-
NR_047666.1 RNA Sequence
- Description
- Transcript Variant: This variant (6) uses an alternate splice site and differs in the 3' terminus, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AK297428, AU121887, BU075732, DC416977
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000019.9 Reference GRCh37.p5 Primary Assembly
- Range
- 16472408..16582762, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000151.1 Alternate HuRef
- Range
- 16041435..16122050, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)