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RHOU ras homolog family member U [ Homo sapiens (human) ]

Gene ID: 58480, updated on 12-May-2016
Official Symbol
RHOUprovided by HGNC
Official Full Name
ras homolog family member Uprovided by HGNC
Primary source
HGNC:HGNC:17794
See related
Ensembl:ENSG00000116574 HPRD:06965; MIM:606366; Vega:OTTHUMG00000037919
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARHU; G28K; WRCH1; hG28K; CDC42L1
Summary
This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011]
Orthologs
Location:
1q42.11-q42.3
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (228644647..228746669)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228780394..228882416)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373132 Neighboring gene RNA, 5S ribosomal 15 Neighboring gene RNA, 5S ribosomal 16 Neighboring gene RNA, 5S ribosomal pseudogene 18 Neighboring gene dual specificity phosphatase 5 pseudogene 1 Neighboring gene RNA, 5S ribosomal 17 Neighboring gene ferritin, heavy polypeptide 1 pseudogene 2 Neighboring gene eukaryotic translation elongation factor 1 alpha 2 pseudogene Neighboring gene uncharacterized LOC105373143

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits.
NHGRI GWA Catalog
Genome-wide association scan of dental caries in the permanent dentition.
NHGRI GWA Catalog
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
NHGRI GWA Catalog
Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.
NHGRI GWA Catalog
Linkage and association of successful aging to the 6q25 region in large Amish kindreds.
NHGRI GWA Catalog
Meta-analysis of genome-wide association scans for genetic susceptibility to endometriosis in Japanese population.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of ras homolog family member U (RHOU) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough RHOU

Included gene: DUSP5P1

Homology

Clone Names

  • FLJ10616, DJ646B12.2, fJ646B12.2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
Rac protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
podosome IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
rho-related GTP-binding protein RhoU
Names
2310026M05Rik
CDC42-like GTPase 1
GTP-binding protein SB128
GTP-binding protein like 1
RHOU
Ryu GTPase
ras homolog gene family, member U
ras-like gene family member U
rho GTPase-like protein ARHU
wnt-1 responsive Cdc42 homolog 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021205.5NP_067028.1  rho-related GTP-binding protein RhoU

    See identical proteins and their annotated locations for NP_067028.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AF211836, AI094830, AL096776, BC040076
    Consensus CDS
    CCDS1575.1
    UniProtKB/Swiss-Prot
    Q7L0Q8
    UniProtKB/TrEMBL
    A0A024R3Q7
    Related
    ENSP00000355652, OTTHUMP00000036026, ENST00000366691, OTTHUMT00000092555
    Conserved Domains (2) summary
    cd04130
    Location:50222
    Wrch_1; Wnt-1 responsive Cdc42 homolog (Wrch-1) is a Rho family GTPase similar to Cdc42
    pfam00071
    Location:51219
    Ras; Ras family

RNA

  1. NR_037962.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. This variant is a readthrough transcript between the upstream non-coding SNHG3 locus DUSP5P (GeneID: 574029) and the downstream RHOU locus (GeneID: 58480). This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AL096776, AL713899, DA321957

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    228644647..228746669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    230032574..230154436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)