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ENOPH1 enolase-phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 58478, updated on 4-May-2015
Official Symbol
ENOPH1provided by HGNC
Official Full Name
enolase-phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:24599
See related
Ensembl:ENSG00000145293; HPRD:17467; Vega:OTTHUMG00000130295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E1; MASA; mtnC; MST145
Orthologs
See ENOPH1 in MapViewer
Location:
4q21.22
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (82430480..82461175)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (83351726..83382245)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene immunoglobulin (CD79A) binding protein 1 pseudogene 4 Neighboring gene uncharacterized LOC105377309 Neighboring gene heterogeneous nuclear ribonucleoprotein D-like Neighboring gene syncytin-1-like Neighboring gene transmembrane protein 150C Neighboring gene ribosomal protein L7a pseudogene 26

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ12594, DKFZp586M0524

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acireductone synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
acireductone synthase activity TAS
Traceable Author Statement
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
L-methionine biosynthetic process from methylthioadenosine IDA
Inferred from Direct Assay
more info
PubMed 
L-methionine biosynthetic process from methylthioadenosine IEA
Inferred from Electronic Annotation
more info
 
L-methionine biosynthetic process from methylthioadenosine TAS
Traceable Author Statement
more info
 
cellular nitrogen compound metabolic process TAS
Traceable Author Statement
more info
 
dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
dephosphorylation TAS
Traceable Author Statement
more info
 
polyamine metabolic process TAS
Traceable Author Statement
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
sulfur amino acid metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
enolase-phosphatase E1
Names
enolase-phosphatase E1
2,3-diketo-5-methylthio-1-phosphopentane phosphatase
ENOPH1
acireductone synthase
NP_001278946.1
NP_067027.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001292017.1NP_001278946.1  enolase-phosphatase E1 isoform 2

    See identical proteins and their annotated locations for NP_001278946.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' terminal exon and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL518796, AW470971, BC065815, CN335976, DA067292
    Consensus CDS
    CCDS75154.1
    UniProtKB/TrEMBL
    D6RA00
    UniProtKB/Swiss-Prot
    Q9UHY7
    Related
    ENSP00000422005, OTTHUMP00000219541, ENST00000509635, OTTHUMT00000363376
    Conserved Domains (2) summary
    pfam13419
    Location:37142
    HAD_2; Haloacid dehalogenase-like hydrolase
    cl21460
    Location:13167
    HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
  2. NM_021204.4NP_067027.1  enolase-phosphatase E1 isoform 1

    See identical proteins and their annotated locations for NP_067027.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AW470971, BC065815, DA067292
    Consensus CDS
    CCDS3594.1
    UniProtKB/Swiss-Prot
    Q9UHY7
    Related
    ENSP00000273920, OTTHUMP00000160806, ENST00000273920, OTTHUMT00000252638
    Conserved Domains (2) summary
    pfam13419
    Location:13230
    HAD_2; Haloacid dehalogenase-like hydrolase
    cl21460
    Location:10258
    HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...

RNA

  1. NR_120457.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' terminal exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AW470971, BC001317, DA067292

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    82430480..82461175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    83328118..83358843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)