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Sh3kbp1 SH3-domain kinase binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 58194, updated on 28-May-2016
Official Symbol
Sh3kbp1provided by MGI
Official Full Name
SH3-domain kinase binding protein 1provided by MGI
Primary source
MGI:MGI:1889583
See related
Ensembl:ENSMUSG00000040990 Vega:OTTMUSG00000019443
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ruk; IN85; Seta; AI447724; 1200007H22Rik; 1700125L08Rik; 5830464D22Rik
Orthologs
Location:
X; X F4
Exon count:
27
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) X NC_000086.7 (159627029..159975920)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (156065340..156413849)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A830080D01 gene Neighboring gene hepatitis B virus x interacting protein pseudogene Neighboring gene transmembrane protein 126A pseudogene Neighboring gene mitogen-activated protein kinase kinase kinase 15 Neighboring gene cofilin 1, non-muscle pseudogene Neighboring gene predicted gene, 39547 Neighboring gene pyruvate dehydrogenase E1 alpha 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
SH3 domain-containing kinase-binding protein 1
Names
SH3-containing, expressed in tumorigenic astrocytes
regulator of ubiquitous kinase

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135727.2NP_001129199.1  SH3 domain-containing kinase-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001129199.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as Ruk1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI447724, AK028299, AK049182, AK080930, AK142295, BB853873
    Consensus CDS
    CCDS53234.1
    UniProtKB/Swiss-Prot
    Q8R550
    UniProtKB/TrEMBL
    Q3TA88, Q3TT90
    Related
    ENSMUSP00000108075, OTTMUSP00000020960, ENSMUST00000112456, OTTMUST00000046424
    Conserved Domains (4) summary
    cd12052
    Location:355
    SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
    cd12055
    Location:102154
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:271326
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    pfam14931
    Location:602660
    IFT20; Intraflagellar transport complex B, subunit 20
  2. NM_001135728.2NP_001129200.1  SH3 domain-containing kinase-binding protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001129200.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3, also known as Rukm3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AI447724, AK004636, AK028299, AK142295
    Consensus CDS
    CCDS53235.1
    UniProtKB/Swiss-Prot
    Q8R550
    UniProtKB/TrEMBL
    Q3TT90
    Related
    ENSMUSP00000108070, OTTMUSP00000020965, ENSMUST00000112451, OTTMUST00000046430
    Conserved Domains (2) summary
    cd12057
    Location:3388
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    pfam14931
    Location:364422
    IFT20; Intraflagellar transport complex B, subunit 20
  3. NM_001290661.1NP_001277590.1  SH3 domain-containing kinase-binding protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001277590.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4, also known as Rukh2) lacks multiple coding exons and contains an alternate 5' exon, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (4) has a shorter N-terminus than isoform 1. Variants 4 and 5 encode the same isoform (4).
    Source sequence(s)
    AI447724, AK028299, AK142295, AK161512
    UniProtKB/Swiss-Prot
    Q8R550
    UniProtKB/TrEMBL
    Q3TT90
    Conserved Domains (1) summary
    TIGR01220
    Location:2389
    Pmev_kin_Gr_pos; phosphomevalonate kinase, ERG8-type, Gram-positive branch
  4. NM_001290664.1NP_001277593.1  SH3 domain-containing kinase-binding protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001277593.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5, also known as Rukh4) lacks multiple coding exons and contains an alternate 5' exon, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (4) has a shorter N-terminus than isoform 1. Variants 4 and 5 encode the same isoform (4).
    Source sequence(s)
    AI447724, AK028299, AK052260, AK142295, AK161512
    UniProtKB/Swiss-Prot
    Q8R550
    UniProtKB/TrEMBL
    Q3TT90
    Conserved Domains (1) summary
    TIGR01220
    Location:2389
    Pmev_kin_Gr_pos; phosphomevalonate kinase, ERG8-type, Gram-positive branch
  5. NM_021389.6NP_067364.2  SH3 domain-containing kinase-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_067364.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as RukdeltaA) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AI447724, AK004636, AK028299, AK030839, AK142295
    Consensus CDS
    CCDS41194.1
    UniProtKB/Swiss-Prot
    Q8R550
    UniProtKB/TrEMBL
    Q3TT90
    Related
    ENSMUSP00000079257, OTTMUSP00000020961, ENSMUST00000080394, OTTMUST00000046425
    Conserved Domains (3) summary
    cd12055
    Location:65117
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:234289
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    pfam14931
    Location:565623
    IFT20; Intraflagellar transport complex B, subunit 20

RNA

  1. NR_110969.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs at the 5' end, lacks an internal exon, and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI447724, AK028299, AK030839, AK142295
  2. NR_110970.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs at the 5' end and uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI447724, AK028299, AK030839, AK142295, AL929452
    Related
    ENSMUST00000112447

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p3 C57BL/6J

    Range
    159627029..159975920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528924.2XP_006528987.1  

    See identical proteins and their annotated locations for XP_006528987.1

    UniProtKB/Swiss-Prot
    Q8R550
    Conserved Domains (4) summary
    cd12052
    Location:355
    SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
    cd12055
    Location:102154
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:315370
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    pfam14931
    Location:646704
    IFT20; Intraflagellar transport complex B, subunit 20
  2. XM_006528928.2XP_006528991.1  

    Conserved Domains (4) summary
    cd12052
    Location:355
    SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
    cd12055
    Location:102154
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:315370
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    pfam14931
    Location:603661
    IFT20; Intraflagellar transport complex B, subunit 20
  3. XM_011247849.1XP_011246151.1  

    See identical proteins and their annotated locations for XP_011246151.1

    UniProtKB/Swiss-Prot
    Q8R550
    Related
    ENSMUSP00000072840, OTTMUSP00000020962, ENSMUST00000073094, OTTMUST00000046427
    Conserved Domains (4) summary
    cd12052
    Location:355
    SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
    cd12055
    Location:102154
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:315370
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    pfam14931
    Location:646704
    IFT20; Intraflagellar transport complex B, subunit 20
  4. XM_006528926.2XP_006528989.1  

    Conserved Domains (4) summary
    cd12052
    Location:355
    SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
    cd12055
    Location:102154
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:290345
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    pfam14931
    Location:621679
    IFT20; Intraflagellar transport complex B, subunit 20
  5. XM_006528925.2XP_006528988.1  

    Conserved Domains (4) summary
    cd12052
    Location:355
    SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
    cd12055
    Location:102154
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:296351
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    pfam14931
    Location:627685
    IFT20; Intraflagellar transport complex B, subunit 20
  6. XM_006528929.2XP_006528992.1  

    Conserved Domains (3) summary
    cd12055
    Location:4395
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:212267
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    pfam14931
    Location:543601
    IFT20; Intraflagellar transport complex B, subunit 20
  7. XM_006528927.2XP_006528990.1  

    Conserved Domains (3) summary
    cd12055
    Location:65117
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:278333
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    pfam14931
    Location:609667
    IFT20; Intraflagellar transport complex B, subunit 20
  8. XM_011247850.1XP_011246152.1  

    Conserved Domains (2) summary
    cd12057
    Location:147202
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    pfam14931
    Location:478536
    IFT20; Intraflagellar transport complex B, subunit 20
  9. XM_006528932.1XP_006528995.1  

    Conserved Domains (2) summary
    cd12057
    Location:3388
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    pfam14931
    Location:321379
    IFT20; Intraflagellar transport complex B, subunit 20
  10. XM_011247851.1XP_011246153.1  

    See identical proteins and their annotated locations for XP_011246153.1

    UniProtKB/Swiss-Prot
    Q8R550
    Conserved Domains (1) summary
    pfam14931
    Location:190248
    IFT20; Intraflagellar transport complex B, subunit 20

Alternate Mm_Celera

Genomic

  1. AC_000042.1 Alternate Mm_Celera

    Range
    142872459..143219838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)