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dedd1 death effector domain-containing 1 [ Danio rerio (zebrafish) ]

Gene ID: 58125, updated on 27-Mar-2024

Summary

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Official Symbol
dedd1provided by ZNC
Official Full Name
death effector domain-containing 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-000616-2
See related
Ensembl:ENSDARG00000002758 AllianceGenome:ZFIN:ZDB-GENE-000616-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable DNA binding activity. Predicted to be involved in extrinsic apoptotic signaling pathway via death domain receptors. Predicted to act upstream of or within apoptotic process and regulation of apoptotic process. Predicted to be located in nucleus. Predicted to be active in nucleolus. Orthologous to human DEDD2 (death effector domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 16
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (10841061..10863042)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (10950159..10972140)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene ATPase Na+/K+ transporting subunit alpha 3b Neighboring gene Rab acceptor 1 (prenylated) Neighboring gene POU class 2 homeobox 2b Neighboring gene Ets2 repressor factor like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The Tetraodon nigroviridis reference transcriptome: developmental transition, length retention and microsynteny of long non-coding RNAs in a compact vertebrate genome. Basu S, et al. Sci Rep, 2016 Sep 15. PMID 27628538, Free PMC Article
  2. Genetic Pathways of Neuroregeneration in a Novel Mild Traumatic Brain Injury Model in Adult Zebrafish. Maheras AL, et al. eNeuro, 2018 Jan-Feb. PMID 29302617, Free PMC Article
  3. HMGA2 contributes to vascular development and sprouting angiogenesis by promoting IGFBP2 production. Wang J, et al. Exp Cell Res, 2021 Nov 1. PMID 34547256
  4. Chronic reduction in cardiac output induces hypoxic signaling in larval zebrafish even at a time when convective oxygen transport is not required. Kopp R, et al. Physiol Genomics, 2010 Sep. PMID 20571107
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-binding death effector domain-containing protein 2; death effector domain-containing 1
Names
death effector domain-conatining 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131602.2 → NP_571677.2  death effector domain-containing 1

    Status: VALIDATED

    Source sequence(s)
    CU468227, FO704889
    UniProtKB/TrEMBL
    A0A8M6YTH0, F1QIL7
    Related
    ENSDARP00000065466.5, ENSDART00000065467.7
    Conserved Domains (1) summary
    cl14633
    Location:15 → 165
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    10841061..10863042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021466747.1 → XP_021322422.1  DNA-binding death effector domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9NZD3
    Related
    ENSDARP00000105333.1, ENSDART00000128762.3
    Conserved Domains (1) summary
    cl14633
    Location:15 → 165
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. XM_017351359.1 → XP_017206848.1  DNA-binding death effector domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M6YTH0, F1QIL7
    Conserved Domains (1) summary
    cl14633
    Location:15 → 165
    DD; Death Domain Superfamily of protein-protein interaction domains

RNA

  1. XR_225138.3 RNA Sequence

  2. XR_001795977.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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