My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    BAX BCL2-associated X protein [ Homo sapiens ]

    Gene ID: 581, updated on 19-May-2012
    Help top of page

    Summary

    Official Symbol
    BAXprovided by HGNC
    Official Full Name
    BCL2-associated X proteinprovided by HGNC
    Primary source
    HGNC:959
    See related
    Ensembl:ENSG00000087088; HPRD:02498; MIM:600040; Vega:OTTHUMG00000160476
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BCL2L4
    Summary
    The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]
    Help top of page

    Genomic context

    Location :
    19q13.3-q13.4
    Sequence :
    Chromosome: 19; NC_000019.9 (49458117..49465055)
    See BAX in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene nucleobindin 1 Neighboring gene dihydrodiol dehydrogenase (dimeric) Neighboring gene ferritin, light polypeptide Neighboring gene glycogen synthase 1 (muscle)

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX. Henry RE, et al. EMBO J, 2012 Jan 13. PMID 22246181.
    2. The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast. Renault TT, et al. FEBS Lett, 2012 Jan 20. PMID 22198199.
    3. Extracellular recombinant annexin II confers UVC-radiation resistance and increases the Bcl-xL to Bax protein ratios in human UVC-radiation-sensitive cells. Kita K, et al. Radiat Res, 2011 Dec. PMID 22141411.
    4. Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis. Niture SK, et al. J Biol Chem, 2011 Dec 30. PMID 22072718.
    5. Bax forms two types of channels, one of which is voltage-gated. Lin SH, et al. Biophys J, 2011 Nov 2. PMID 22067154.

    See all (620) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Fluazinam-induced apoptosis of SH-SY5Y cells is mediated by accumulation of TP53, reduced levels of Bcl-2 and increased levels of Bax.
      Title: Fluazinam-induced apoptosis of SH-SY5Y cells is mediated by p53 and Bcl-2 family proteins.
    2. The key differential events in apoptotic cells are p53-dependent activation of the DR4 death receptor pathway, caspase 8-mediated cleavage of BID, and BID-dependent activation of poised BAX at the mitochondria.
      Title: A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX.
    3. Utilizing a simple model to fit the neutron data, we observed that a significant amount of the protein mass protrudes above the membrane, in contrast to the conjecture that all of the membrane-associated Bax states are umbrella-like.
      Title: Interaction of the full-length Bax protein with biomimetic mitochondrial liposomes: a small-angle neutron scattering and fluorescence study.
    4. Among differentiated thyroid carcinomas cases, expression of Bax was high in 75.7% and low or absent in 24.3%.
      Title: Clinicopathological correlations of Bcl-xL and Bax expression in differentiated thyroid carcinoma.
    5. BAX, the BCL-2-associated X protein, is a cardinal proapoptotic member of the BCL-2 family, which regulates the critical balance between cellular life and death.
      Title: BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore.
    6. UVRAG has cytoprotective functions in the cytosol that control the localization of Bax in tumor cells exposed to apoptotic stimuli
      Title: A critical role for UVRAG in apoptosis.
    7. PGC1alpha induces apoptosis in presence of Bax.
      Title: Bax is necessary for PGC1α pro-apoptotic effect in colorectal cancer cells.
    8. eIF4E siRNA increased Bax/Bcl-2 ratio in a breast cancer cell line
      Title: Knockdown of eIF4E suppresses cell growth and migration, enhances chemosensitivity and correlates with increase in Bax/Bcl-2 ratio in triple-negative breast cancer cells.
    9. Data indicate that the induction of apoptosis appears to occur through the upregulation of Fas/FasL and Bax, downregulation of Bcl-2.
      Title: Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2.
    10. The apoptosis process in human neutrophils exposed to NDMA is dependent on the intrinsic pathway mediated by Bax and Mcl-1 proteins.
      Title: The effect of N-nitrosodimethylamine (NDMA) on Bax and Mcl-1 expression in human neutrophils.
    Submit: New GeneRIF Correction See all (480)
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Colorectal cancer

    Help top of page

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax PubMed
    env Syncytial apoptosis mediated by the fusion of cells expressing HIV-1 gp120 with cells expressing the CD4/CXCR4 receptor/coreceptor complex causes phosphorylation of p53 on serine 15 and Bax upregulation PubMed
    Tat tat Expression of HIV-1 Tat in hematopoietic cells results in downregulation of Bcl-2 and upregulation of Bax, resulting in the induction of apoptosis PubMed
    tat Tumor protein p73 interferes with Tat-mediated apoptosis by preventing the up-regulation of Bax and down-regulation of Bcl-2 proteins in astrocytes PubMed
    tat HIV-1 Tat upregulates the expression of BAX in Kaposi's sarcoma cells PubMed
    Vpr vpr HIV-1 Vpr-induced apoptosis is mediated via Bax, downstream of ATR activation PubMed
    vpr Mice transgenic for the HIV-1 vpr gene have enhanced apoptotic death of T lymphocytes with up-regulation of Bax suggesting the involvement of Bax in the apoptotic processes PubMed
    vpr Constitutive expression of HIV-1 Vpr in Jurkat cells resulted in downregulation of Bax, suggesting Vpr is a negative regulator of apoptosis PubMed
    vpr HIV-1 Vpr induction of mitochondrial membrane permeabilization through binding to adenine nucleotide translocator (ANT) is enhanced by Bax PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    AY217036.1 NP_000537.2 TP53    BIND  PubMed p53 interacts with Bax. 
    NC_000019.8 NP_000537.2 TP53    BIND  PubMed p53 interacts with bax promoter. 
    NC_000019.8 NP_005418.1 TP73    BIND  PubMed p73-alpha interacts with BAX promoter. 
    NP_620116.1 NP_055232.1 BBC3    BIND  PubMed Bax interacts with PUMA. 
    NP_620116.1 NP_000624.1 BCL2    BIND  PubMed Bcl-2 interacts with Bax. 
    NP_620116.1 BCL2    BIND  PubMed Bax interacts with Bcl-2. 
    NP_620116.1 NP_612815.1 BCL2L1    BIND  PubMed Bax interacts with Bcl-XL via its BH3 domain. This interaction was modeled on a demonstrated interaction between mouse Bax and human Bcl-XL. 
    NP_620116.1 NP_612815.1 BCL2L1    BIND  PubMed Bax interacts with Bcl-xL. 
    NP_620116.1 NP_001187.1 BID    BIND  PubMed Bax interacts with Bid. 
    NP_620116.1 NP_071434.2 MOAP1    BIND  PubMed Bax interacts with MAP-1 via its BH1, BH2, and BH3 domains. This interaction was modeled on a demonstrated interaction between mouse Bax and human MAP-1. 
    NP_620116.1 NP_003937.1 NOL3    BIND  PubMed ARC interacts with Bax. 
    Q07814 Q16611 BAK1    HPRD  PubMed  
    Q07814 Q9BXH1 BBC3    HPRD  PubMed  
    Q07814 P10415 BCL2    HPRD  PubMed  
    Q07814 Q16548 BCL2A1    HPRD  PubMed  
    Q07814 Q07817 BCL2L1    HPRD  PubMed  
    Q07814 Q9HD36 BCL2L10    HPRD  PubMed  
    Q07814 P55957 BID    HPRD  PubMed  
    Q07814 O75460 ERN1    HPRD  PubMed  
    Q07814 P22001 KCNA3    HPRD  PubMed  
    Q07814 Q07820 MCL1    HPRD  PubMed  
    Q07814 Q96BY2 MOAP1    HPRD  PubMed  
    Q07814 O60936 NOL3    HPRD  PubMed  
    Q07814 Q13794 PMAIP1    HPRD  PubMed  
    Q07814 P62136 PPP1CA    HPRD  PubMed  
    Q07814 P31947 SFN    HPRD  PubMed  
    Q07814 Q9Y371 SH3GLB1    HPRD  PubMed  
    Q07814 P12235 SLC25A4    HPRD  PubMed  
    Q07814 P21796 VDAC1    HPRD  PubMed  
    Q07814 P27348 YWHAQ    HPRD  PubMed  
    Q07814 Q8IVG9     HPRD  PubMed  
    U17193.1 NP_001505.1 GTF2B    BIND  PubMed GTF2B (TFIIB) interacts with the Bax promoter. 
    U17193.1 NP_002447.3 MUC1    BIND  PubMed MUC1 C-ter interacts with the Bax promoter. 
    U17193.1 TAF1    BIND  PubMed TAF1 (TAFII250) interacts with the Bax promoter. 
    U17193.1 NP_003185.1 TBP    BIND  PubMed TBP interacts with the Bax promoter. 
    U17193.1 NP_000537.2 TP53    BIND  PubMed p53 interacts with the Bax promoter. 
    BioGRID:107057 BioGRID:107054 BAK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107057 BioGRID:107057 BAX    BioGRID  PubMed Two-hybrid 
    BioGRID:107057 BioGRID:107068 BCL2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107057 BioGRID:107069 BCL2A1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    NP_612815.1 BCL2L1    BIND  PubMed Bax interacts with Bcl-XL. 
    BioGRID:107057 BioGRID:107070 BCL2L1    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Reconstituted Complex 
    BioGRID:107057 BioGRID:115334 BCL2L10    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107057 BioGRID:107071 BCL2L2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107057 BioGRID:127211 BNIPL    BioGRID  PubMed Two-hybrid 
    BioGRID:107057 BioGRID:250472 Bak1    BioGRID  PubMed Affinity Capture-Western 
    NP_000385.1 CRYAA    BIND  PubMed HalphaA-crystallin interacts with Bax. 
    NP_001876.1 CRYAB    BIND  PubMed HalphaB-crystallin interacts with Bax. 
    BioGRID:107057 BioGRID:109561 HSPD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107057 BioGRID:110338 MCL1    BioGRID  PubMed Two-hybrid 
    BioGRID:107057 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    NP_071434.2 MOAP1    BIND  PubMed MAP-1 interacts with an unspecified isoform of Bax. 
    BioGRID:107057 BioGRID:122069 MOAP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107057 BioGRID:36612 OYE2    BioGRID  PubMed Dosage Rescue; Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:107057 BioGRID:116446 PARK7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107057 BioGRID:111379 PMAIP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107057 BioGRID:129106 RNF144B    BioGRID  PubMed Affinity Capture-Western 
    AAF81225.1 SH3GLB1    BIND  PubMed An unspecified isoform of Bax interacts with SH3GLB1. 
    BioGRID:107057 BioGRID:119289 SH3GLB1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107057 BioGRID:106788 SLC25A4    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107057 BioGRID:112506 SNCA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107057 BioGRID:121308 TOMM22    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107057 BioGRID:115716 TOMM40    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107057 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107057 BioGRID:125434 UHRF2    BioGRID  PubMed Far Western 
    BioGRID:107057 BioGRID:113259 VDAC1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107057 BioGRID:108822 XRCC6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107057 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation, translocation and oligomerization of BAX, organism-specific biosystem (from REACTOME)
      Activation, translocation and oligomerization of BAX, organism-specific biosystemAs a result of binding to Bid, Bax oligomerizes and integrates in the outer mitochondrial membrane that triggers cytochrome c release. Bax mitochondrial membrane insertion triggered by Bid may repr...
    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
      Caspase cascade in apoptosis, organism-specific biosystem
      Caspase cascade in apoptosis
    • Ceramide signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Ceramide signaling pathway, organism-specific biosystem
      Ceramide signaling pathway
    • Colorectal cancer, organism-specific biosystem (from KEGG)
      Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Colorectal cancer, conserved biosystem (from KEGG)
      Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
      Glucocorticoid receptor regulatory network, organism-specific biosystem
      Glucocorticoid receptor regulatory network
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Huntington's disease, organism-specific biosystem (from KEGG)
      Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Huntington's disease, conserved biosystem (from KEGG)
      Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-5 Signaling Pathway, organism-specific biosystemInterleukin-5 belongs to the family of cytokines, which includes IL-3 and GM-CSF. It signals through a receptor complex comprising of an IL-5 receptor alpha subunit (IL5RA), and a common beta chain w...
    • IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-7 Signaling Pathway, organism-specific biosystemInterleukin-7 belongs to a family of cytokines, which includes IL-2, IL-4, IL-9, IL-15 and IL-21. It signals through a receptor complex consisting of IL-7 receptor alpha chain (IL7RA) and a common ga...
    • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
      Intrinsic Pathway for Apoptosis, organism-specific biosystemThe intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stress...
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Prion diseases, organism-specific biosystem (from KEGG)
      Prion diseases, organism-specific biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
    • Prion diseases, conserved biosystem (from KEGG)
      Prion diseases, conserved biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Signaling events mediated by HDAC Class III, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class III, organism-specific biosystem
      Signaling events mediated by HDAC Class III
    • Syndecan-2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-2-mediated signaling events, organism-specific biosystem
      Syndecan-2-mediated signaling events
    • TP53 network, organism-specific biosystem (from WikiPathways)
      TP53 network, organism-specific biosystemP53 is not a lonely genome guardian, it operates with the assistance of p73 and p63 within a complex network including distinct but complementary pathways. This protein family presents a high le...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Validated targets of C-MYC transcriptional activation, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional activation, organism-specific biosystem
      Validated targets of C-MYC transcriptional activation
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    BH3 domain binding IDA
    Inferred from Direct Assay
    more info
    		  
    BH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    lipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    B cell apoptosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    DNA fragmentation involved in apoptotic nuclear change IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    activation of pro-apoptotic gene products TAS
    Traceable Author Statement
    more info
    		  
    apoptosis in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    apoptotic mitochondrial changes IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    cleavage of lamin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    establishment or maintenance of transmembrane electrochemical gradient IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    induction of apoptosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    induction of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    induction of apoptosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    induction of apoptosis by extracellular signals IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    induction of apoptosis by intracellular signals IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    induction of apoptosis by intracellular signals TAS
    Traceable Author Statement
    more info
    		  
    induction of retinal programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mitochondrial fragmentation involved in apoptosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrial fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of survival gene product expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear fragmentation involved in apoptotic nuclear change IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of neuron apoptosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of protein oligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein oligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of mitochondrial membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    regulation of protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    release of matrix enzymes from mitochondria IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to toxin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transformed cell apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    Bcl-2 family protein complex IDA
    Inferred from Direct Assay
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
    		  
    mitochondrial permeability transition pore complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    pore complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    apoptosis regulator BAX
    Names
    apoptosis regulator BAX
    bcl2-L-4
    bcl-2-like protein 4
    BCL2-associated X protein omega
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012191.1 RefSeqGene

      Range
      5001..11939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004324.3 → NP_004315.1  apoptosis regulator BAX isoform beta

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta) encodes the longest isoform (beta).
      Source sequence(s)
      BC014175, BE396495, BM706954, T29044
      Consensus CDS
      CCDS12744.1
      UniProtKB/Swiss-Prot
      Q07812
      Related
      ENSP00000293288, OTTHUMP00000218291, ENST00000293288, OTTHUMT00000360762
      Conserved Domains (1) summary
      cd06845
      Location:25 – 163
      Blast Score: 327
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

    2. NM_138761.3 → NP_620116.1  apoptosis regulator BAX isoform alpha

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha) contains a distinct 3' coding region and 3' UTR when compared to variant beta. It encodes an isoform (alpha) that has a shorter and different C terminus, as compared to isoform beta. Isoform alpha is also known as psi.
      Source sequence(s)
      AI565203, BC014175, BE396495
      Consensus CDS
      CCDS12742.1
      UniProtKB/Swiss-Prot
      Q07812
      Related
      ENSP00000263262, OTTHUMP00000218296, ENST00000345358, OTTHUMT00000360767
      Conserved Domains (2) summary
      cd06845
      Location:25 – 164
      Blast Score: 343
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:5 – 192
      Blast Score: 606
      bcl-2; apoptosis regulator

    3. NM_138763.3 → NP_620118.1  apoptosis regulator BAX isoform delta

      Status: REVIEWED

      Description
      Transcript Variant: This variant (delta) lacks a segment within the coding region, and contains a distinct 3' coding region and 3' UTR, when compared to variant beta. The translation remains in-frame, and results in an isoform (delta) that is missing an internal segment, and has a shorter and different C terminus, as compared to isoform beta.
      Source sequence(s)
      AI565203, BC014175, BE396495
      Consensus CDS
      CCDS12743.1
      UniProtKB/Swiss-Prot
      Q07812
      Related
      ENSP00000346461, OTTHUMP00000218295, ENST00000354470, OTTHUMT00000360766
      Conserved Domains (2) summary
      cd06845
      Location:34 – 115
      Blast Score: 284
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:5 – 143
      Blast Score: 423
      bcl-2; apoptosis regulator

    4. NM_138764.4 → NP_620119.2  apoptosis regulator BAX isoform sigma

      Status: REVIEWED

      Description
      Transcript Variant: This variant (sigma) contains a distinct 3' coding region and 3' UTR when compared to variant beta. It encodes an isoform (sigma) that has a shorter and different C terminus, as compared to isoform beta.
      Source sequence(s)
      AI565203, BC014175, BE396495
      Consensus CDS
      CCDS12745.2
      UniProtKB/Swiss-Prot
      Q07812
      Related
      ENSP00000389971, OTTHUMP00000218293, ENST00000415969, OTTHUMT00000360764
      Conserved Domains (2) summary
      cd06845
      Location:25 – 158
      Blast Score: 325
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:5 – 179
      Blast Score: 538
      bcl-2; apoptosis regulator

    RNA

    1. NR_027882.1 RNA Sequence

      Description
      Transcript Variant: This variant (epsilon) contains an extra segment within the 3' coding region, when compared to variant beta. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF007826, AI565203, BC014175, BE396495

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      49458117..49465055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      45835055..45841975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_138762.2: Suppressed sequence

      Description
      NM_138762.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC026803.7 (192192..199130) None
    genomic AF008195.1 AAD01415.1
    genomic AF008196.1 AAD01415.1
      AAD01416.1
    genomic AF020360.1 None
    genomic AF339054.1 AAL73333.1
    genomic AY217036.1 AAO22992.1
    genomic CH471177.1 EAW52415.1
      EAW52416.1
      EAW52417.1
      EAW52418.1
      EAW52419.1
      EAW52420.1
      EAW52421.1
    mRNA AF007826.1 AAD22706.1
    mRNA AF247393.1 AAF71267.1
    mRNA AF250190.1 AAF82094.1
    mRNA AI565203.1 None
    mRNA AJ417988.1 CAD10744.1
    mRNA AJ586909.1 CAE52909.1
    mRNA AJ586910.1 CAE52910.1
    mRNA AK291076.1 BAF83765.1
    mRNA BC014175.2 AAH14175.1
    mRNA BE396495.1 None
    mRNA BM706954.1 None
    mRNA HQ889830.1 ADZ05507.1
    mRNA L22473.1 AAA03619.1
    mRNA L22474.1 AAA03620.1
    mRNA L22475.1 AAA03621.1
    mRNA T29044.1 None
    mRNA U19599.1 AAC50142.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95074 GenPept UniProtKB/TrEMBL:O95074
    Q07812.1 GenPept UniProtKB/Swiss-Prot:Q07812
    Q5ZPJ0 GenPept UniProtKB/TrEMBL:Q5ZPJ0
    Q5ZPJ1 GenPept UniProtKB/TrEMBL:Q5ZPJ1
    Q8WXU1 GenPept UniProtKB/TrEMBL:Q8WXU1
    Q9UEI8 GenPept UniProtKB/TrEMBL:Q9UEI8
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...