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    PTPRS protein tyrosine phosphatase, receptor type, S [ Homo sapiens ]

    Gene ID: 5802, updated on 11-May-2012
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    Summary

    Official Symbol
    PTPRSprovided by HGNC
    Official Full Name
    protein tyrosine phosphatase, receptor type, Sprovided by HGNC
    Primary source
    HGNC:9681
    See related
    Ensembl:ENSG00000105426; HPRD:03344; MIM:601576
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PTPSIGMA
    Summary
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    19p13.3
    Sequence :
    Chromosome: 19; NC_000019.9 (5205519..5340814, complement)
    See PTPRS in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene ubiquitin-like with PHD and ring finger domains 1 Neighboring gene microRNA 4747 Neighboring gene lysine (K)-specific demethylase 4B Neighboring gene FLJ00291 protein Neighboring gene ribosomal protein L32 pseudogene 34 Neighboring gene zinc and ring finger 4 Neighboring gene placenta-specific 2 (non-protein coding)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers. Morris LG, et al. Proc Natl Acad Sci U S A, 2011 Nov 22. PMID 22065749.
    2. Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma. Hou L, et al. Acta Biochim Biophys Sin (Shanghai), 2011 Dec. PMID 22027896.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling. Berndt JD, et al. J Cell Biol, 2011 Sep 5. PMID 21875946.
    5. Protein tyrosine phosphatase σ regulates the synapse number of zebrafish olfactory sensory neurons. Chen X, et al. J Neurochem, 2011 Nov. PMID 21812780.

    See all (34) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma.
      Title: Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma.
    2. Intragenic microdeletions of the EGFR phosphatase PTPRS were found frequently (26%) in head and neck cancers, identifying this gene as a target of 19p13 loss.
      Title: Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers.
    3. Transgenic zebrafish carrying a promoter-driven expression vector reveal the increased density of olfactory sensory neuron-specific cell synapses.
      Title: Protein tyrosine phosphatase σ regulates the synapse number of zebrafish olfactory sensory neurons.
    4. Data show that PTPsigma localizes to PtdIns3P-positive membranes in cells, and this vesicular localization is enhanced during autophagy.
      Title: Identification of PTPsigma as an autophagic phosphatase.
    5. crystallographic analyses of a shared HSPG-CSPG binding site reveal a conformational plasticity that can accommodate diverse glycosaminoglycans with comparable affinities; HS and analogs induced RPTPsigma ectodomain oligomerization which was inhibited ...
      Title: Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension.
    6. The receptor protein tyrosine phosphatase sigma (RPTPsigma) has now been identified as a receptor for inhibitory chondroitin sulfate proteoglycans.
      Title: A new role for RPTPsigma in spinal cord injury: signaling chondroitin sulfate proteoglycan inhibition.
    7. Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.
      Title: Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.
    8. In colorectal tumors, microsatellite repeats mutation rates are higher than the mean mutation frequency
      Title: Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability.
    10. Three SNPs that flank exon 8 are associated with ulcerative colitis. The presence of these SNPs is associated with novel splicing that removes the third immunoglobulin-like domain (exon 9) from the extracellular portion of PTPsigma.
      Title: Protein-tyrosine phosphatase sigma is associated with ulcerative colitis.
    Submit: New GeneRIF Correction See all (13)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q13332 Q12873 CHD3    HPRD  PubMed  
    Q13332 P26641 EEF1G    HPRD  PubMed  
    Q13332 P00533 EGFR    HPRD  PubMed  
    Q13332 Q99689 FEZ1    HPRD  PubMed  
    Q13332 Q92993 KAT5    HPRD  PubMed  
    Q13332 Q9P2H0 KIAA1377    HPRD  PubMed  
    Q13332 Q9Y3A3 MOB4    HPRD  PubMed  
    Q13332 P35080 PFN2    HPRD  PubMed  
    Q13332 Q13136 PPFIA1    HPRD  PubMed  
    Q13332 O75334 PPFIA2    HPRD  PubMed  
    Q13332 O75145 PPFIA3    HPRD  PubMed  
    Q13332 P21246 PTN    HPRD  PubMed  
    Q13332 P18433 PTPRA    HPRD  PubMed  
    Q13332 P23468 PTPRD    HPRD  PubMed  
    Q13332 P23469 PTPRE    HPRD  PubMed  
    Q13332 P28827 PTPRM    HPRD  PubMed  
    Q13332 Q16849 PTPRN    HPRD  PubMed  
    Q13332 Q15286 RAB35    HPRD  PubMed  
    Q13332 Q15047 SETDB1    HPRD  PubMed  
    Q13332 Q8IWV7 UBR1    HPRD  PubMed  
    Q13332 Q13432 UNC119    HPRD  PubMed  
    Q13332 Q9BVJ6 UTP14A    HPRD  PubMed  
    BioGRID:111766 BioGRID:107532 CHD3    BioGRID  PubMed Two-hybrid 
    BioGRID:111766 BioGRID:108257 EEF1G    BioGRID  PubMed Two-hybrid 
    BioGRID:111766 BioGRID:108290 EIF4A2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111766 BioGRID:114997 FEZ1    BioGRID  PubMed Two-hybrid 
    BioGRID:111766 BioGRID:115779 KAT5    BioGRID  PubMed Two-hybrid 
    BioGRID:111766 BioGRID:121617 KIAA1377    BioGRID  PubMed Two-hybrid 
    BioGRID:111766 BioGRID:117369 MOB4    BioGRID  PubMed Two-hybrid 
    BioGRID:111766 BioGRID:111238 PFN2    BioGRID  PubMed Two-hybrid 
    BioGRID:111766 BioGRID:114072 PPFIA1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111766 BioGRID:114071 PPFIA2    BioGRID  PubMed Two-hybrid 
    BioGRID:111766 BioGRID:114111 PPFIA3    BioGRID  PubMed Two-hybrid 
    BioGRID:111766 BioGRID:111731 PTN    BioGRID  PubMed Two-hybrid 
    BioGRID:111766 BioGRID:111753 PTPRD    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111766 BioGRID:112171 RYK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111766 BioGRID:115202 SETDB1    BioGRID  PubMed Two-hybrid 
    BioGRID:111766 BioGRID:113131 TUBB2A    BioGRID  PubMed Two-hybrid 
    BioGRID:111766 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111766 BioGRID:128238 UBR1    BioGRID  PubMed Two-hybrid 
    BioGRID:111766 BioGRID:114548 UNC119    BioGRID  PubMed Two-hybrid 
    BioGRID:111766 BioGRID:116026 UTP14A    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transmembrane receptor protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    cerebellum development IEA
    Inferred from Electronic Annotation
    more info
    		  
    cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
    		  
    corpus callosum development IEA
    Inferred from Electronic Annotation
    more info
    		  
    hippocampus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    spinal cord development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    receptor-type tyrosine-protein phosphatase S
    Names
    receptor-type tyrosine-protein phosphatase S
    R-PTP-S
    R-PTP-sigma
    protein tyrosine phosphatase PTPsigma
    receptor-type tyrosine-protein phosphatase sigma
    protein tyrosine phosphatase, receptor type, sigma
    NP_002841.3
    NP_570923.2
    NP_570924.2
    NP_570925.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002850.3 → NP_002841.3  receptor-type tyrosine-protein phosphatase S isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB209333, AC118535, BC029496, BC104812, CN413749, CN413752, U35234, U40317
      Consensus CDS
      CCDS45930.1
      UniProtKB/Swiss-Prot
      Q13332
      UniProtKB/TrEMBL
      Q59FX6
      UniProtKB/TrEMBL
      Q8NHS7
      Related
      ENSP00000349932, ENST00000357368
      Conserved Domains (8) summary
      cd00047
      Location:1418 – 1647
      Blast Score: 889
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:332 – 421
      Blast Score: 188
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:50 – 121
      Blast Score: 141
      Ig; Immunoglobulin domain
      cd05739
      Location:259 – 327
      Blast Score: 352
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      pfam07679
      Location:33 – 124
      Blast Score: 218
      I-set; Immunoglobulin I-set domain
      smart00194
      Location:1392 – 1647
      Blast Score: 984
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cl00065
      Location:1036 – 1097
      Blast Score: 106
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:152 – 233
      Blast Score: 322
      Ig; Immunoglobulin domain

    2. NM_130853.2 → NP_570923.2  receptor-type tyrosine-protein phosphatase S isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks four internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks four internal segments, as compared to isoform 1.
      Source sequence(s)
      AB209333, AC118535, BC029496, BC104812
      Consensus CDS
      CCDS12139.1
      UniProtKB/Swiss-Prot
      Q13332
      UniProtKB/TrEMBL
      Q59FX6
      UniProtKB/TrEMBL
      Q8NHS7
      Related
      ENSP00000327313, ENST00000353284
      Conserved Domains (8) summary
      cd00047
      Location:971 – 1200
      Blast Score: 880
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319 – 408
      Blast Score: 191
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05738
      Location:152 – 226
      Blast Score: 354
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246 – 314
      Blast Score: 352
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      pfam07679
      Location:33 – 124
      Blast Score: 218
      I-set; Immunoglobulin I-set domain
      smart00194
      Location:945 – 1200
      Blast Score: 972
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cl00065
      Location:605 – 666
      Blast Score: 107
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:32 – 120
      Blast Score: 145
      Ig; Immunoglobulin domain

    3. NM_130854.2 → NP_570924.2  receptor-type tyrosine-protein phosphatase S isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks four internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks four internal segments, as compared to isoform 1.
      Source sequence(s)
      AB209333, AC118535, BC029496, BC104812, CN413749, CN413752, U35234, U40317
      Consensus CDS
      CCDS12140.1
      UniProtKB/Swiss-Prot
      Q13332
      UniProtKB/TrEMBL
      Q59FX6
      UniProtKB/TrEMBL
      Q8NHS7
      Related
      ENSP00000269907, ENST00000348075
      Conserved Domains (8) summary
      cd00047
      Location:1380 – 1609
      Blast Score: 888
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319 – 408
      Blast Score: 189
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:50 – 121
      Blast Score: 142
      Ig; Immunoglobulin domain
      cd05738
      Location:152 – 226
      Blast Score: 352
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246 – 314
      Blast Score: 351
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      pfam07679
      Location:33 – 124
      Blast Score: 218
      I-set; Immunoglobulin I-set domain
      smart00194
      Location:1354 – 1609
      Blast Score: 984
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cl00065
      Location:1014 – 1075
      Blast Score: 106
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    4. NM_130855.2 → NP_570925.2  receptor-type tyrosine-protein phosphatase S isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks three internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks three internal segments, as compared to isoform 1.
      Source sequence(s)
      AB209333, AC118535, BC029496, BC104812, U35234
      UniProtKB/Swiss-Prot
      Q13332
      UniProtKB/TrEMBL
      Q59FX6
      UniProtKB/TrEMBL
      Q8NHS7
      Conserved Domains (8) summary
      cd00047
      Location:975 – 1204
      Blast Score: 880
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323 – 412
      Blast Score: 191
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05738
      Location:152 – 224
      Blast Score: 344
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250 – 318
      Blast Score: 352
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      pfam07679
      Location:33 – 124
      Blast Score: 218
      I-set; Immunoglobulin I-set domain
      smart00194
      Location:949 – 1204
      Blast Score: 973
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cl00065
      Location:609 – 670
      Blast Score: 107
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:32 – 120
      Blast Score: 145
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      5205519..5340814, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      4967302..5101977, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC005335.1 (6233..39081) None
    genomic AC005338.1 AAC27825.1
    genomic AC005788.1 AAC62834.1
    genomic AC005790.1 AAC62832.1
    genomic AC118535.1 (18123..32886) None
    genomic CH471139.2 EAW69170.1
      EAW69171.1
      EAW69172.1
      EAW69173.1
      EAW69174.1
      EAW69175.1
      EAW69176.1
      EAW69177.1
      EAW69178.1
      EAW69179.1
    mRNA AB209333.1 BAD92570.1
    mRNA BC029496.1 AAH29496.1
    mRNA BC104812.1 AAI04813.1
    mRNA BC143286.1 None
    mRNA BC143287.1 AAI43288.1
    mRNA BC148297.2 AAI48298.1
    mRNA BI461316.1 None
    mRNA CN413749.1 None
    mRNA CN413752.1 None
    mRNA S78080.1 AAB21146.2
    mRNA S78086.1 AAB21147.2
    mRNA U35234.1 AAC50299.1
    mRNA U40317.1 AAC50567.1
    mRNA U41725.1 AAD09360.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13332.3 GenPept UniProtKB/Swiss-Prot:Q13332
    Q16343 GenPept UniProtKB/TrEMBL:Q16343
    Q59FX6 GenPept UniProtKB/TrEMBL:Q59FX6
    Q8NHS7 GenPept UniProtKB/TrEMBL:Q8NHS7
    Q9UM81 GenPept UniProtKB/TrEMBL:Q9UM81
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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