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PTPRS protein tyrosine phosphatase, receptor type S [ Homo sapiens (human) ]

Gene ID: 5802, updated on 8-May-2016
Official Symbol
PTPRSprovided by HGNC
Official Full Name
protein tyrosine phosphatase, receptor type Sprovided by HGNC
Primary source
HGNC:HGNC:9681
See related
Ensembl:ENSG00000105426 HPRD:03344; MIM:601576; Vega:OTTHUMG00000180325
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTPSIGMA
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Orthologs
Location:
19p13.3
Exon count:
40
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (5205503..5340803, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5205514..5340814, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ubiquitin like with PHD and ring finger domains 1 Neighboring gene microRNA 4747 Neighboring gene lysine demethylase 4B Neighboring gene uncharacterized LOC105372253 Neighboring gene ribosomal protein L32 pseudogene 34 Neighboring gene uncharacterized LOC105372252 Neighboring gene zinc and ring finger 4 Neighboring gene tissue differentiation-inducing non-protein coding RNA

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of protein tyrosine phosphatase, receptor type, Sigma (PTPRS) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

  • ECM proteoglycans, organism-specific biosystem (from REACTOME)
    ECM proteoglycans, organism-specific biosystemProteoglycans are major components of the extracellular matrix. In cartilage the matrix constitutes more than 90% of tissue dry weight. Proteoglycans are proteins substituted with glycosaminoglycans ...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • SALM protein interactions at the synapse, organism-specific biosystem (from REACTOME)
    SALM protein interactions at the synapse, organism-specific biosystemRecruitment of receptors and ion channels to the postsynaptic membrane is the last step in synapse formation. Many of these proteins interact directly or indirectly with postsynaptic density-95 (PSD9...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane receptor protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cerebellum development IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
corpus callosum development IEA
Inferred from Electronic Annotation
more info
 
establishment of endothelial intestinal barrier IEA
Inferred from Electronic Annotation
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
spinal cord development IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
receptor-type tyrosine-protein phosphatase S
Names
R-PTP-S
R-PTP-sigma
protein tyrosine phosphatase PTPsigma
protein tyrosine phosphatase, receptor type, S
receptor-type tyrosine-protein phosphatase sigma
NP_002841.3
NP_570923.2
NP_570924.2
NP_570925.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033964.1 RefSeqGene

    Range
    5001..140296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002850.3NP_002841.3  receptor-type tyrosine-protein phosphatase S isoform 1 precursor

    See identical proteins and their annotated locations for NP_002841.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB209333, AC118535, BC029496, BC104812, CN413749, CN413752, U35234, U40317
    Consensus CDS
    CCDS45930.1
    UniProtKB/Swiss-Prot
    Q13332
    UniProtKB/TrEMBL
    Q59FX6, Q8NHS7
    Related
    ENSP00000349932, ENST00000357368
    Conserved Domains (9) summary
    cd05738
    Location:152235
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:259327
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150223
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:13921647
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:251328
    IG_like; Immunoglobulin like
    cd00047
    Location:14181647
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:332421
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  2. NM_130853.2NP_570923.2  receptor-type tyrosine-protein phosphatase S isoform 3 precursor

    See identical proteins and their annotated locations for NP_570923.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks four internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks four internal segments, as compared to isoform 1.
    Source sequence(s)
    AB209333, AC118535, BC029496, BC104812
    Consensus CDS
    CCDS12139.1
    UniProtKB/Swiss-Prot
    Q13332
    UniProtKB/TrEMBL
    Q59FX6, Q8NHS7
    Conserved Domains (9) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150214
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:9451200
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:238315
    IG_like; Immunoglobulin like
    cd00047
    Location:9711200
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  3. NM_130854.2NP_570924.2  receptor-type tyrosine-protein phosphatase S isoform 2 precursor

    See identical proteins and their annotated locations for NP_570924.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks four internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks four internal segments, as compared to isoform 1.
    Source sequence(s)
    AB209333, AC118535, BC029496, BC104812, CN413749, CN413752, U35234, U40317
    Consensus CDS
    CCDS12140.1
    UniProtKB/Swiss-Prot
    Q13332
    UniProtKB/TrEMBL
    Q59FX6, Q8NHS7
    Related
    ENSP00000269907, ENST00000348075
    Conserved Domains (9) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150214
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:13541609
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:238315
    IG_like; Immunoglobulin like
    cd00047
    Location:13801609
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  4. NM_130855.2NP_570925.2  receptor-type tyrosine-protein phosphatase S isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks three internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks three internal segments, as compared to isoform 1.
    Source sequence(s)
    AB209333, AC118535, BC029496, BC104812, U35234
    Consensus CDS
    CCDS74265.1
    UniProtKB/Swiss-Prot
    Q13332
    UniProtKB/TrEMBL
    A0A0A0MR60, Q59FX6, Q8NHS7
    Related
    ENSP00000327313, ENST00000353284
    Conserved Domains (9) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150214
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:9491204
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:242319
    IG_like; Immunoglobulin like
    cd00047
    Location:9751204
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    5205503..5340803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259601.2XP_005259658.1  

    See identical proteins and their annotated locations for XP_005259658.1

    Conserved Domains (9) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150214
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:13791634
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:238315
    IG_like; Immunoglobulin like
    cd00047
    Location:14051634
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  2. XM_006722810.2XP_006722873.1  

    See identical proteins and their annotated locations for XP_006722873.1

    Conserved Domains (9) summary
    cd05738
    Location:152235
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:255323
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150223
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:13881643
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:247324
    IG_like; Immunoglobulin like
    cd00047
    Location:14141643
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:328417
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  3. XM_005259610.1XP_005259667.1  

    Related
    ENSP00000262963, ENST00000262963
    Conserved Domains (9) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150214
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:9411196
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:238315
    IG_like; Immunoglobulin like
    cd00047
    Location:9671196
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  4. XM_005259609.1XP_005259666.1  

    See identical proteins and their annotated locations for XP_005259666.1

    UniProtKB/Swiss-Prot
    Q13332
    Related
    ENSP00000467398, OTTHUMP00000263970, ENST00000592099, OTTHUMT00000450763
    Conserved Domains (9) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150214
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:9451200
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:238315
    IG_like; Immunoglobulin like
    cd00047
    Location:9711200
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  5. XM_005259607.1XP_005259664.1  

    Conserved Domains (9) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150214
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:13501605
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:238315
    IG_like; Immunoglobulin like
    cd00047
    Location:13761605
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  6. XM_005259606.1XP_005259663.1  

    See identical proteins and their annotated locations for XP_005259663.1

    UniProtKB/Swiss-Prot
    Q13332
    Related
    ENSP00000465443, OTTHUMP00000263971, ENST00000588012, OTTHUMT00000450764
    Conserved Domains (9) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150214
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:13541609
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:238315
    IG_like; Immunoglobulin like
    cd00047
    Location:13801609
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  7. XM_005259600.1XP_005259657.1  

    See identical proteins and their annotated locations for XP_005259657.1

    Conserved Domains (9) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150214
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:13791634
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:238315
    IG_like; Immunoglobulin like
    cd00047
    Location:14051634
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  8. XM_006722819.1XP_006722882.1  

    Conserved Domains (9) summary
    cd05738
    Location:152235
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:255323
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150223
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:9661221
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:247324
    IG_like; Immunoglobulin like
    cd00047
    Location:9921221
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:328417
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  9. XM_006722820.1XP_006722883.1  

    Conserved Domains (9) summary
    cd05738
    Location:152235
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:255323
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150223
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:9541209
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:247324
    IG_like; Immunoglobulin like
    cd00047
    Location:9801209
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:328417
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  10. XM_006722818.1XP_006722881.1  

    Conserved Domains (9) summary
    cd05738
    Location:152235
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:255323
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150223
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:9701225
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:247324
    IG_like; Immunoglobulin like
    cd00047
    Location:9961225
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:328417
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  11. XM_006722817.1XP_006722880.1  

    Conserved Domains (9) summary
    cd05738
    Location:152235
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:255323
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150223
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:13591614
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:247324
    IG_like; Immunoglobulin like
    cd00047
    Location:13851614
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:328417
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  12. XM_006722812.1XP_006722875.1  

    Conserved Domains (9) summary
    cd05738
    Location:152235
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:255323
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150223
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:13791634
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:247324
    IG_like; Immunoglobulin like
    cd00047
    Location:14051634
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:328417
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  13. XM_006722815.1XP_006722878.1  

    Conserved Domains (9) summary
    cd05738
    Location:152235
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:255323
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150223
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:13681623
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:247324
    IG_like; Immunoglobulin like
    cd00047
    Location:13941623
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:328417
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  14. XM_006722811.1XP_006722874.1  

    Conserved Domains (9) summary
    cd05738
    Location:152235
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:255323
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150223
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:13841639
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:247324
    IG_like; Immunoglobulin like
    cd00047
    Location:14101639
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:328417
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  15. XM_006722814.1XP_006722877.1  

    UniProtKB/Swiss-Prot
    Q13332
    Conserved Domains (9) summary
    cd05738
    Location:152235
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:255323
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150223
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:13721627
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:247324
    IG_like; Immunoglobulin like
    cd00047
    Location:13981627
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:328417
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  16. XM_006722808.1XP_006722871.1  

    See identical proteins and their annotated locations for XP_006722871.1

    Conserved Domains (9) summary
    cd05738
    Location:152235
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:255323
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150223
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:13881643
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:247324
    IG_like; Immunoglobulin like
    cd00047
    Location:14141643
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:328417
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  17. XM_006722809.2XP_006722872.1  

    See identical proteins and their annotated locations for XP_006722872.1

    Conserved Domains (9) summary
    cd05738
    Location:152235
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:255323
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150223
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:13881643
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:247324
    IG_like; Immunoglobulin like
    cd00047
    Location:14141643
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:328417
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  18. XM_011528157.1XP_011526459.1  

    Conserved Domains (9) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00408
    Location:150214
    IGc2; Immunoglobulin C-2 Type
    smart00194
    Location:9611216
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:238315
    IG_like; Immunoglobulin like
    cd00047
    Location:9871216
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  19. XM_011528158.1XP_011526460.1  

    Conserved Domains (3) summary
    smart00194
    Location:601856
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:627856
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:141238
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    5205046..5340693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)