These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
Genomic
-
NG_012047.2 RefSeqGene
- Range
- 5001..86167
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_000465.2 → NP_000456.2 BRCA1-associated RING domain protein 1
Status: REVIEWED
- Source sequence(s)
-
BC126426, BC126428, BU677525, BX098964, DB088853
- Consensus CDS
-
CCDS2397.1
- UniProtKB/TrEMBL
-
A0AVN2
- UniProtKB/Swiss-Prot
-
Q99728
- Related
- ENSP00000260947, OTTHUMP00000163973, ENST00000260947, OTTHUMT00000256602
- Conserved Domains (6) summary
-
- cd00027
Location:568 – 641
Blast Score: 127
- BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
- cd00162
Location:50 – 89
Blast Score: 100
- RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
- cd00204
Location:424 – 544
Blast Score: 313
- ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
- pfam12796
Location:432 – 524
Blast Score: 275
- Ank_2; Ankyrin repeats (3 copies)
- pfam13923
Location:46 – 86
Blast Score: 97
- zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
- cl00038
Location:669 – 712
Blast Score: 98
- BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000002.11 Reference GRCh37.p5 Primary Assembly
- Range
- 215593262..215674428, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000134.1 Alternate HuRef
- Range
- 207449412..207530541, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)