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PTPRH protein tyrosine phosphatase, receptor type H [ Homo sapiens (human) ]

Gene ID: 5794, updated on 12-May-2016
Official Symbol
PTPRHprovided by HGNC
Official Full Name
protein tyrosine phosphatase, receptor type Hprovided by HGNC
Primary source
HGNC:HGNC:9672
See related
Ensembl:ENSG00000080031 HPRD:03942; MIM:602510; Vega:OTTHUMG00000180701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAP1; R-PTP-H
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
Orthologs
Location:
19q13.4
Exon count:
23
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (55181247..55209506, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55692615..55720874, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101930593 Neighboring gene dynein (axonemal) assembly factor 3 Neighboring gene uncharacterized LOC102724352 Neighboring gene synaptotagmin 5 Neighboring gene transmembrane protein 86B Neighboring gene microRNA 6804 Neighboring gene protein phosphatase 6 regulatory subunit 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ39938, MGC133058, MGC133059

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane receptor protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
receptor-type tyrosine-protein phosphatase H
Names
protein tyrosine phosphatase, receptor type, H
stomach cancer-associated protein tyrosine phosphatase 1
transmembrane-type protein-tyrosine phosphatase type H
NP_001154912.2
NP_002833.4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161440.2NP_001154912.2  receptor-type tyrosine-protein phosphatase H isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC010327, KF456611
    Consensus CDS
    CCDS54321.1
    Related
    ENSP00000263434, OTTHUMP00000265017, ENST00000263434, OTTHUMT00000452650
    Conserved Domains (3) summary
    smart00194
    Location:641900
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:669899
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:208286
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. NM_002842.4NP_002833.4  receptor-type tyrosine-protein phosphatase H isoform 1 precursor

    See identical proteins and their annotated locations for NP_002833.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC010327, KF456611
    Consensus CDS
    CCDS33110.1
    Related
    ENSP00000365528, OTTHUMP00000265016, ENST00000376350, OTTHUMT00000452649
    Conserved Domains (3) summary
    smart00194
    Location:8191078
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:8471077
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:386464
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    55181247..55209506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527187.1XP_011525489.1  

    Conserved Domains (3) summary
    smart00194
    Location:648907
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:676906
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:215293
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_011527184.1XP_011525486.1  

    Conserved Domains (3) summary
    smart00194
    Location:8221081
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:8501080
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:393471
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. XM_011527185.1XP_011525487.1  

    Conserved Domains (3) summary
    smart00194
    Location:8261073
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:8541074
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:393471
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  4. XM_011527183.1XP_011525485.1  

    Conserved Domains (3) summary
    smart00194
    Location:8261085
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:8541084
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:393471
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  5. XM_011527188.1XP_011525490.1  

    See identical proteins and their annotated locations for XP_011525490.1

    Conserved Domains (3) summary
    smart00194
    Location:632891
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:660890
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:199277
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  6. XM_011527189.1XP_011525491.1  

    See identical proteins and their annotated locations for XP_011525491.1

    Conserved Domains (3) summary
    smart00194
    Location:632891
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:660890
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:199277
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  7. XM_011527186.1XP_011525488.1  

    Conserved Domains (3) summary
    smart00194
    Location:826972
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:854972
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:393471
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  8. XM_011527190.1XP_011525492.1  

    Conserved Domains (1) summary
    cd00063
    Location:393471
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. XR_935847.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    55686188..55714448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)