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PTPRE protein tyrosine phosphatase, receptor type E [ Homo sapiens (human) ]

Gene ID: 5791, updated on 26-May-2016
Official Symbol
PTPREprovided by HGNC
Official Full Name
protein tyrosine phosphatase, receptor type Eprovided by HGNC
Primary source
HGNC:HGNC:9669
See related
Ensembl:ENSG00000132334 HPRD:02956; MIM:600926; Vega:OTTHUMG00000019254
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTPE; HPTPE; R-PTP-EPSILON
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Oct 2015]
Orthologs
Location:
10q26
Exon count:
27
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (127907061..128085916)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (129705325..129884180)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene BUB1 mitotic checkpoint serine/threonine kinase pseudogene 1 Neighboring gene clarin 3 Neighboring gene lncRNA antisense to PTPRE protein-coding gene Neighboring gene marker of proliferation Ki-67 Neighboring gene long intergenic non-protein coding RNA 1163

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
NHGRI GWA Catalog
Genome-wide association with select biomarker traits in the Framingham Heart Study.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies PTPRE, a member of the protein tyrosine phosphatase family, is important for HIV-1 replication PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ57799, FLJ58245, DKFZp313F1310

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
negative regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of mast cell activation IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine phosphatase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
receptor-type tyrosine-protein phosphatase epsilon
Names
protein tyrosine phosphatase, receptor type, E
protein tyrosine phosphatase, receptor type, epsilon polypeptide
NP_006495.1
NP_569119.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029511.1 RefSeqGene

    Range
    5001..183795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316676.1NP_001303605.1  receptor-type tyrosine-protein phosphatase epsilon isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform 3.
    Source sequence(s)
    AF406557, AK026334, AL390236, BC031078, BC050062, BC071573, X54134
    UniProtKB/Swiss-Prot
    P23469
    UniProtKB/TrEMBL
    Q96P81
    Conserved Domains (2) summary
    smart00194
    Location:145404
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:172404
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. NM_001316677.1NP_001303606.1  receptor-type tyrosine-protein phosphatase epsilon isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' exon in place of the first 3 exons and lacks a large part of the 3' UTR compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. The encoded protein is a receptor type isoform of this PTP. Variants 1, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AK026334, AK291828, BC071573
    UniProtKB/Swiss-Prot
    P23469
    Conserved Domains (2) summary
    smart00194
    Location:134393
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:161393
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. NM_001323354.1NP_001310283.1  receptor-type tyrosine-protein phosphatase epsilon isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), along with variants 1 and 4, encodes isoform 1.
    Source sequence(s)
    AL390236
  4. NM_001323355.1NP_001310284.1  receptor-type tyrosine-protein phosphatase epsilon isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL158166, AL390236
  5. NM_001323356.1NP_001310285.1  receptor-type tyrosine-protein phosphatase epsilon isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL158166, AL390236
  6. NM_001323357.1NP_001310286.1  receptor-type tyrosine-protein phosphatase epsilon isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL390236
  7. NM_006504.5NP_006495.1  receptor-type tyrosine-protein phosphatase epsilon isoform 1 precursor

    See identical proteins and their annotated locations for NP_006495.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks a 5' exon compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. The encoded protein is a receptor type isoform of this PTP. Variants 1, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AF406557, AK026334, AL390236, BC031078, BC071573, X54134
    Consensus CDS
    CCDS7657.1
    UniProtKB/Swiss-Prot
    P23469
    UniProtKB/TrEMBL
    Q96P81
    Related
    ENSP00000254667, OTTHUMP00000020735, ENST00000254667, OTTHUMT00000050990
    Conserved Domains (2) summary
    smart00194
    Location:134393
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:161393
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  8. NM_130435.4NP_569119.1  receptor-type tyrosine-protein phosphatase epsilon isoform 2

    See identical proteins and their annotated locations for NP_569119.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in place of the first 5 exons compared to variant 3. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 3. The encoded protein is a cytoplasmic isoform of this PTP.
    Source sequence(s)
    AK026334, AK290414, AL390236, BC071573, DA470230
    Consensus CDS
    CCDS7658.1
    UniProtKB/Swiss-Prot
    P23469
    UniProtKB/TrEMBL
    A8K2Z9
    Related
    ENSP00000303350, OTTHUMP00000020736, ENST00000306042, OTTHUMT00000050991
    Conserved Domains (2) summary
    smart00194
    Location:76335
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:103335
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    127907061..128085916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539993.1XP_011538295.1  

    Conserved Domains (2) summary
    smart00194
    Location:154413
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:181413
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. XM_011539995.1XP_011538297.1  

    Conserved Domains (2) summary
    smart00194
    Location:154413
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:181413
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. XM_011539996.1XP_011538298.1  

    Conserved Domains (2) summary
    smart00194
    Location:154413
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:181413
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  4. XM_011539994.1XP_011538296.1  

    Conserved Domains (2) summary
    smart00194
    Location:154412
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:181412
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  5. XM_011539998.1XP_011538300.1  

    Conserved Domains (2) summary
    smart00194
    Location:154355
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:181355
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  6. XM_005252691.1XP_005252748.1  

    See identical proteins and their annotated locations for XP_005252748.1

    UniProtKB/Swiss-Prot
    P23469
    Conserved Domains (2) summary
    smart00194
    Location:134393
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:161393
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  7. XM_005252692.1XP_005252749.1  

    UniProtKB/Swiss-Prot
    P23469
    Conserved Domains (2) summary
    smart00194
    Location:134393
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:161393
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  8. XM_011539997.1XP_011538299.1  

    Conserved Domains (2) summary
    smart00194
    Location:74333
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:101333
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  9. XM_011540000.1XP_011538302.1  

    See identical proteins and their annotated locations for XP_011538302.1

    Conserved Domains (2) summary
    smart00194
    Location:35294
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:62294
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  10. XM_011539999.1XP_011538301.1  

    See identical proteins and their annotated locations for XP_011538301.1

    Conserved Domains (2) summary
    smart00194
    Location:205468
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:233468
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RNA

  1. XR_945793.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    129987736..130166586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)