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PTPRB protein tyrosine phosphatase, receptor type B [ Homo sapiens (human) ]

Gene ID: 5787, updated on 26-May-2016
Official Symbol
PTPRBprovided by HGNC
Official Full Name
protein tyrosine phosphatase, receptor type Bprovided by HGNC
Primary source
HGNC:HGNC:9665
See related
Ensembl:ENSG00000127329 HPRD:01474; MIM:176882; Vega:OTTHUMG00000169499
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTPB; HPTPB; VEPTP; HPTP-BETA; R-PTP-BETA
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Orthologs
Location:
12q15
Exon count:
36
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (70516850..70637440, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (70910630..71031220, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 4 Neighboring gene uncharacterized LOC105369827 Neighboring gene uncharacterized LOC105369828 Neighboring gene protein tyrosine phosphatase, receptor type R Neighboring gene fumarylacetoacetate hydrolase domain containing 2 pseudogene 1 Neighboring gene uncharacterized LOC105369829

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 induces CD4 association with lymphocyte surface molecules CD3, CD11a, CD27, CD45RA, CD45RB, CD45RO, CD49d, CD38, CD26, CD59, CD95 and class I MHC molecules PubMed
Tat tat HIV-1 Tat C treated human brain microvascular endothelial cells result in downregulation and dissociation of VE-PTP and SHP2 from VE-cadherin PubMed

Go to the HIV-1, Human Interaction Database

  • Adherens junction, organism-specific biosystem (from KEGG)
    Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Adherens junction, conserved biosystem (from KEGG)
    Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ44133, MGC59935, MGC142023, DKFZp686E2262, DKFZp686H15164

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane receptor protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphate-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
receptor-type tyrosine-protein phosphatase beta
Names
VE-PTP
protein tyrosine phosphatase, receptor type, B
protein tyrosine phosphatase, receptor type, beta polypeptide
vascular endothelial protein tyrosine phosphatase
NP_001103224.1
NP_001193900.1
NP_001193901.1
NP_002828.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029940.1 RefSeqGene

    Range
    5001..125591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001109754.2NP_001103224.1  receptor-type tyrosine-protein phosphatase beta isoform a

    See identical proteins and their annotated locations for NP_001103224.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC025569, BC051329, BC101679, BC143360, DN999550
    Consensus CDS
    CCDS44943.1
    UniProtKB/Swiss-Prot
    P23467
    UniProtKB/TrEMBL
    Q86VA4
    Related
    ENSP00000334928, OTTHUMP00000241328, ENST00000334414, OTTHUMT00000404435
    Conserved Domains (5) summary
    smart00194
    Location:19202178
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:19472178
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:328419
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00161
    Location:2294
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00041
    Location:13941466
    fn3; Fibronectin type III domain
  2. NM_001206971.1NP_001193900.1  receptor-type tyrosine-protein phosphatase beta isoform c precursor

    See identical proteins and their annotated locations for NP_001193900.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (c) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC025569, BC143360, X54131
    Consensus CDS
    CCDS55845.1
    UniProtKB/Swiss-Prot
    P23467
    Related
    ENSP00000447302, OTTHUMP00000241331, ENST00000550857, OTTHUMT00000404438
    Conserved Domains (4) summary
    smart00194
    Location:16121870
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:16391870
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:110201
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:10861158
    fn3; Fibronectin type III domain
  3. NM_001206972.1NP_001193901.1  receptor-type tyrosine-protein phosphatase beta isoform d precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (d) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC025569, BC101679, BC143356, BC143360, X54131
    Consensus CDS
    CCDS55846.1
    UniProtKB/Swiss-Prot
    P23467
    Related
    ENSP00000438927, OTTHUMP00000241330, ENST00000538708, OTTHUMT00000404437
    Conserved Domains (4) summary
    smart00194
    Location:16121870
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:16391870
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:110201
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:10861158
    fn3; Fibronectin type III domain
  4. NM_002837.4NP_002828.3  receptor-type tyrosine-protein phosphatase beta isoform b precursor

    See identical proteins and their annotated locations for NP_002828.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC025569, BC101679, BC143360, X54131
    Consensus CDS
    CCDS44944.1
    UniProtKB/Swiss-Prot
    P23467
    Related
    ENSP00000261266, OTTHUMP00000241332, ENST00000261266, OTTHUMT00000404439
    Conserved Domains (4) summary
    smart00194
    Location:17021960
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:17291960
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:110201
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:11761248
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    70516850..70637440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538614.1XP_011536916.1  

    Related
    ENSP00000448058, OTTHUMP00000241329, ENST00000550358, OTTHUMT00000404436
    Conserved Domains (5) summary
    smart00194
    Location:18322090
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:18592090
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:328419
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00161
    Location:2294
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00041
    Location:11281206
    fn3; Fibronectin type III domain
  2. XM_006719528.1XP_006719591.1  

    Conserved Domains (5) summary
    smart00194
    Location:19202178
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:19472178
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:328419
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00161
    Location:2294
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00041
    Location:13941466
    fn3; Fibronectin type III domain
  3. XM_006719529.2XP_006719592.1  

    Conserved Domains (4) summary
    smart00194
    Location:17021960
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:17291960
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:110201
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:11761248
    fn3; Fibronectin type III domain

RNA

  1. XR_944651.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    70879907..71000488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)