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    ZNF410 zinc finger protein 410 [ Homo sapiens ]

    Gene ID: 57862, updated on 11-May-2012
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    Summary

    Official Symbol
    ZNF410provided by HGNC
    Official Full Name
    zinc finger protein 410provided by HGNC
    Primary source
    HGNC:20144
    See related
    Ensembl:ENSG00000119725; HPRD:18339; Vega:OTTHUMG00000171257
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APA1; APA-1
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    Genomic context

    Location :
    14q24.3
    Sequence :
    Chromosome: 14; NC_000014.8 (74353318..74398991)
    See ZNF410 in Epigenomics, MapViewer

    Chromosome 14 - NC_000014.8Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506498 Neighboring gene prostaglandin reductase 2 Neighboring gene family with sequence similarity 161, member B Neighboring gene coenzyme Q6 homolog, monooxygenase (S. cerevisiae) Neighboring gene ectonucleoside triphosphate diphosphohydrolase 5 Neighboring gene ribosomal protein L41 pseudogene 4

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    2. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142.
    3. Dairy products, polymorphisms in the vitamin D receptor gene and colorectal adenoma recurrence. Hubner RA, et al. Int J Cancer, 2008 Aug 1. PMID 18470879.
    4. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.

    See all (11) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. VDR polymorphism genotypes and haplotypes did not directly alter recurrence risk, but the reduction in risk associated with high dairy product intake was confined to individuals with ApaI aA/AA genotype.
      Title: Dairy products, polymorphisms in the vitamin D receptor gene and colorectal adenoma recurrence.
    3. APA1 has a role in inducing extracellular matrix remodeling genes
      Title: Induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q86VK4 Q8N726 CDKN2A    HPRD  PubMed  
    Q86VK4 GRINL1A downstream protein Gdown1 POLR2M    HPRD  PubMed  
    BioGRID:121792 BioGRID:114118 BLZF1    BioGRID  PubMed Two-hybrid 
    BioGRID:121792 BioGRID:123498 POLR2M    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Potential readthrough

    Included gene: PTGR2

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    zinc finger protein 410
    Names
    zinc finger protein 410
    another partner for ARF 1
    zinc finger protein APA-1
    clones 23667 and 23775 zinc finger protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242924.1 → NP_001229853.1  zinc finger protein 410 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a)
      Source sequence(s)
      AA652386, AC005480, AC005520, AK293350, DC379519
      Consensus CDS
      CCDS55929.1
      Related
      ENSP00000407130, OTTHUMP00000245603, ENST00000442160, OTTHUMT00000412595
      Conserved Domains (3) summary
      COG5048
      Location:269 – 516
      Blast Score: 86
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:206 – 317
      Blast Score: 90
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      pfam13465
      Location:342 – 367
      Blast Score: 103
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001242926.1 → NP_001229855.1  zinc finger protein 410 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in both the 5' and central coding regions, and it also lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AA652386, BC050683, DC379519
      Consensus CDS
      CCDS55930.1
      UniProtKB/Swiss-Prot
      Q86VK4
      Related
      ENSP00000323293, OTTHUMP00000245597, ENST00000324593, OTTHUMT00000412585
      Conserved Domains (2) summary
      COG5189
      Location:189 – 300
      Blast Score: 92
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      pfam13465
      Location:325 – 350
      Blast Score: 100
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001242927.1 → NP_001229856.1  zinc finger protein 410 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 5' coding region, and it also lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AA652386, AC005480, AK299138, DC379519
      Consensus CDS
      CCDS55931.1
      UniProtKB/Swiss-Prot
      Q86VK4
      Related
      ENSP00000442228, OTTHUMP00000245595, ENST00000540593, OTTHUMT00000412583
      Conserved Domains (2) summary
      COG5189
      Location:116 – 227
      Blast Score: 91
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      pfam13465
      Location:252 – 277
      Blast Score: 101
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001242928.1 → NP_001229857.1  zinc finger protein 410 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in its 5' UTR and 5' coding region, uses an alternate downstream start codon, and includes alternate exon structure in the 3' coding region, compared to variant 1. The encoded isoform (e) has distinct N- and C-termini and is shorter than isoform a.
      Source sequence(s)
      AA652386, BC000330, DC379519
      Conserved Domains (2) summary
      pfam13465
      Location:129 – 154
      Blast Score: 98
      zf-H2C2_2; Zinc-finger double domain
      pfam13900
      Location:273 – 310
      Blast Score: 189
      GVQW; Putative binding domain

    5. NM_021188.2 → NP_067011.1  zinc finger protein 410 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, and it also lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AA652386, AC005480, AK223261, DC379519
      Consensus CDS
      CCDS9821.1
      UniProtKB/TrEMBL
      Q53FM1
      UniProtKB/Swiss-Prot
      Q86VK4
      Related
      ENSP00000451763, OTTHUMP00000245605, ENST00000555044, OTTHUMT00000412597
      Conserved Domains (2) summary
      COG5189
      Location:189 – 300
      Blast Score: 91
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      pfam13465
      Location:325 – 350
      Blast Score: 103
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_040251.1 RNA Sequence

      Description
      Transcript Variant: This variant (6) lacks an alternate exon and uses an alternate splice site in the 5' region, and also lacks an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA652386, AC005480, AK298520, DC379519

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000014.8 Reference GRCh37.p5 Primary Assembly

      Range
      74353318..74398991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000146.1 Alternate HuRef

      Range
      54520379..54565864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC005480.3 (77099..94107) None
    genomic AC005520.2 None
    genomic CH471061.1 EAW81136.1
      EAW81137.1
      EAW81138.1
      EAW81139.1
      EAW81140.1
      EAW81141.1
      EAW81142.1
      EAW81143.1
    mRNA AA652386.1 None
    mRNA AK223261.1 BAD96981.1
    mRNA AK293350.1 BAG56866.1
    mRNA AK298307.1 BAG60561.1
    mRNA AK298520.1 BAG60724.1
    mRNA AK299138.1 BAG61190.1
    mRNA AK301382.1 BAG62922.1
    mRNA AK303834.1 BAG64780.1
    mRNA AK304609.1 BAG65394.1
    mRNA AK309957.1 None
    mRNA AK310031.1 None
    mRNA AK315206.1 BAG37643.1
    mRNA BC000330.2 None
    mRNA BC004357.1 None
    mRNA BC050683.1 AAH50683.1
    mRNA DC379519.1 None
    mRNA U90919.1 AAB51059.1
    other-genetic EU446839.1 ABZ92368.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q53FM1 GenPept UniProtKB/TrEMBL:Q53FM1
    Q86VK4.2 GenPept UniProtKB/Swiss-Prot:Q86VK4
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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