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    KIAA1967 KIAA1967 [ Homo sapiens ]

    Gene ID: 57805, updated on 20-May-2012

    Summary

    Official Symbol
    KIAA1967provided by HGNC
    Official Full Name
    KIAA1967provided by HGNC
    Primary source
    HGNC:23360
    See related
    Ensembl:ENSG00000158941; HPRD:09159; MIM:607359; Vega:OTTHUMG00000162249
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DBC1; DBC-1; NET35; p30DBC; p30 DBC

    Genomic context

    Location :
    8p22
    Sequence :
    Chromosome: 8; NC_000008.10 (22462145..22477984)
    See KIAA1967 in Epigenomics, MapViewer

    Chromosome 8 - NC_000008.10Genomic Context describing neighboring genes Neighboring gene PDZ and LIM domain 2 (mystique) Neighboring gene chromosome 8 open reading frame 58 Neighboring gene bridging integrator 3 Neighboring gene uncharacterized LOC80094 Neighboring gene early growth response 3

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q8N163 O14920 IKBKB    HPRD  PubMed  
    BioGRID:121775 BioGRID:121429 ACTR3B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121775 BioGRID:114528 ASH2L    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:121775 BioGRID:121270 C11orf30    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:121775 BioGRID:114417 CCNA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121775 BioGRID:107457 CDK7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121775 BioGRID:107459 CDK9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121775 BioGRID:114791 CIAO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121775 BioGRID:244244 Cep170    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121775 BioGRID:131875 GSTK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121775 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121775 BioGRID:123914 KAT8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121775 BioGRID:123873 KBTBD7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121775 BioGRID:110279 MAGEA6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121775 BioGRID:114879 MAGED1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121775 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121775 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Two-hybrid 
    BioGRID:121775 BioGRID:116000 NEK6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121775 BioGRID:114667 PNMA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121775 BioGRID:111822 RAD21    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:121775 BioGRID:111864 RBBP5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:121775 BioGRID:116067 RUVBL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121775 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121775 BioGRID:119572 TH1L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121775 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:121775 BioGRID:119068 WRAP73    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121775 BioGRID:121994 ZNF335    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of catalytic activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of catalytic activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DBIRD complex subunit KIAA1967
    Names
    DBIRD complex subunit KIAA1967
    p30 DBC protein
    deleted in breast cancer 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021174.5NP_066997.3  DBIRD complex subunit KIAA1967

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein coding transcript.
      Source sequence(s)
      AL137523, AL834351, BC065495, DA110888
      Consensus CDS
      CCDS34863.1
      UniProtKB/Swiss-Prot
      Q8N163
      Related
      ENSP00000373930, OTTHUMP00000225109, ENST00000389279, OTTHUMT00000375868
      Conserved Domains (2) summary
      pfam14443
      Location:339443
      Blast Score: 494
      DBC1; DBC1
      pfam14444
      Location:55112
      Blast Score: 284
      S1-like; S1-like

    RNA

    1. NR_033902.1 RNA Sequence

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL137523, AL834351, BC065495, DA721640

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000008.10 Reference GRCh37.p5 Primary Assembly

      Range
      22462145..22477984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000140.1 Alternate HuRef

      Range
      21004993..21021131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199205.1: Suppressed sequence

      Description
      NM_199205.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC037459.16 (125544..141271) None
    genomic CH471080.2 EAW63658.1
      EAW63659.1
      EAW63660.1
      EAW63661.1
      EAW63662.1
    genomic HD117867.1 CBX74356.1
    genomic HH735892.1 CBW53721.1
    mRNA AB075847.1 BAB85553.1
    mRNA AF293335.1 AAG02472.1
    mRNA AK022661.1 BAB14163.1
    mRNA AK095712.1 BAG53111.1
    mRNA AK096547.1 None
    mRNA AK314535.1 BAG37126.1
    mRNA AL137523.1 CAB70788.3
    mRNA AL834162.1 CAD38866.1
    mRNA AL834351.1 CAD39016.1
    mRNA AL834352.1 CAD39017.1
    mRNA BC003172.1 None
    mRNA BC018269.1 AAH18269.2
    mRNA BC065495.1 AAH65495.1
    mRNA BI561261.1 None
    mRNA BX390251.1 None
    mRNA BX640952.1 CAE45976.1
    mRNA DA110888.1 None
    mRNA DA721640.1 None
    other-genetic AM392706.1 CAL37584.1
    other-genetic AM393823.1 CAL38698.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N163.2 GenPept UniProtKB/Swiss-Prot:Q8N163

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