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    PTPN6 protein tyrosine phosphatase, non-receptor type 6 [ Homo sapiens ]

    Gene ID: 5777, updated on 19-May-2012
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    Summary

    Official Symbol
    PTPN6provided by HGNC
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 6provided by HGNC
    Primary source
    HGNC:9658
    See related
    Ensembl:ENSG00000111679; HPRD:01475; MIM:176883; Vega:OTTHUMG00000168518
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1
    Summary
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    12p13
    Sequence :
    Chromosome: 12; NC_000012.11 (7055740..7070479)
    See PTPN6 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene chromosome 12 open reading frame 57 Neighboring gene RNA, U7 small nuclear 1 Neighboring gene microRNA 200c Neighboring gene microRNA 141

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines. Kim EJ, et al. Immunology, 2012 Mar. PMID 22043923.
    2. Epithelial-specific methylation marker: a potential plasma biomarker in advanced non-small cell lung cancer. Vinayanuwattikun C, et al. J Thorac Oncol, 2011 Nov. PMID 21964525.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. The SHP-1 protein tyrosine phosphatase negatively modulates Akt signaling in the ghrelin/GHSR1a system. Lodeiro M, et al. Mol Biol Cell, 2011 Nov. PMID 21900501.
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.

    See all (259) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. impaired signaling is associated with enhanced phagocytosis in neonatal monocyte-derived macrophages
      Title: Enhanced phagocytosis in neonatal monocyte-derived macrophages is associated with impaired SHP-1 signaling.
    2. data demonstrate that constitutive activation of STAT3 in Sezary syndrome is not due to the loss of SHP-1, but is mediated by constitutive aberrant activation of JAK family members
      Title: Constitutive activation of STAT3 in Sézary syndrome is independent of SHP-1.
    3. regulation of the TLR3/TRIF-mediated pathway required the combined action of SHP-1 and SHP-2, which could be accomplished by CD300f but not CD300a.
      Title: CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines.
    4. These findings showed a novel role for SHP-1 in the regulation of Akt activity through the modulation of the ghrelin/GHSR1a system signaling
      Title: The SHP-1 protein tyrosine phosphatase negatively modulates Akt signaling in the ghrelin/GHSR1a system.
    5. Methylation at the SHP-1 promoter in plasma is associated with non-small cell lung cancer.
      Title: Epithelial-specific methylation marker: a potential plasma biomarker in advanced non-small cell lung cancer.
    6. 5-aza-dc can induce SHP1 expression and inhibit JAK2/STAT3/STAT5 signalling
      Title: Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling.
    7. in serum- or IGF-1-stimulated breast cancer MCF-7 cells, JNK induces SHP1 expression through the binding of AP-4 and RFX-1 transcription factors to the epithelial tissue-specific SHP1 promoter.
      Title: Breast cancer cells proliferation is regulated by tyrosine phosphatase SHP1 through c-jun N-terminal kinase and cooperative induction of RFX-1 and AP-4 transcription factors.
    8. SHP-1 could be a new biologic indicator at baseline of IMA sensitivity in patients with chronic myelogenous leukemia.
      Title: SHP-1 expression accounts for resistance to imatinib treatment in Philadelphia chromosome-positive cells derived from patients with chronic myeloid leukemia.
    9. SHP-1 antagonizes the action of receptor and non-receptor-tyrosine kinases on GIV and down-regulates the phospho-GIV-PI3K-Akt axis of signaling.
      Title: Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway.
    10. Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation
      Title: Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation.
    Submit: New GeneRIF Correction See all (93)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_536858.1 NP_001744.2 CAV1    BIND  PubMed caveolin-1 interacts with PTP-1C. 
    P29350 P00519 ABL1    HPRD  PubMed  
    P29350 P12814 ACTN1    HPRD  PubMed  
    P29350 O43707 ACTN4    HPRD  PubMed  
    P29350 P11274 BCR    HPRD  PubMed  
    P29350 Q8WV28 BLNK    HPRD  PubMed  
    P29350 Q7Z6A9 BTLA    HPRD  PubMed  
    P29350 O95866 C6orf25    HPRD  PubMed  
    P29350 Q03135 CAV1    HPRD  PubMed  
    P29350 P22681 CBL    HPRD  PubMed  
    P29350 P20273 CD22    HPRD  PubMed  
    P29350 P20963 CD247    HPRD  PubMed  
    P29350 Q8TDQ1 CD300LF    HPRD  PubMed  
    P29350 P20138 CD33    HPRD  PubMed  
    P29350 P06127 CD5    HPRD  PubMed  
    P29350 P21854 CD72    HPRD  PubMed  
    P29350 P11912 CD79A    HPRD  PubMed  
    P29350 P40259 CD79B    HPRD  PubMed  
    P29350 P13688 CEACAM1    HPRD  PubMed  
    P29350 Q9UMR7 CLEC4A    HPRD  PubMed  
    P29350 P32927 CSF2RB    HPRD  PubMed  
    P29350 P35222 CTNNB1    HPRD  PubMed  
    P29350 O60716 CTNND1    HPRD  PubMed  
    P29350 Q86UP6 CUZD1    HPRD  PubMed  
    P29350 P61073 CXCR4    HPRD  PubMed  
    P29350 Q99704 DOK1    HPRD  PubMed  
    P29350 P00533 EGFR    HPRD  PubMed  
    P29350 P19235 EPOR    HPRD  PubMed  
    P29350 P03372 ESR1    HPRD  PubMed  
    P29350 P25445 FAS    HPRD  PubMed  
    P29350 P31994 FCGR2B    HPRD  PubMed  
    P29350 P36888 FLT3    HPRD  PubMed  
    P29350 Q9UQC2 GAB2    HPRD  PubMed  
    P29350 P10912 GHR    HPRD  PubMed  
    P29350 P62993 GRB2    HPRD  PubMed  
    P29350 P31260 HOXA10    HPRD  PubMed  
    P29350 P17181 IFNAR1    HPRD  PubMed  
    P29350 P14784 IL2RB    HPRD  PubMed  
    P29350 P24394 IL4R    HPRD  PubMed  
    P29350 P40189 IL6ST    HPRD  PubMed  
    P29350 P06213 INSR    HPRD  PubMed  
    P29350 Q9Y4H2 IRS2    HPRD  PubMed  
    P29350 Insulin receptor substrate 4 IRS4    HPRD  PubMed  
    P29350 P23458 JAK1    HPRD  PubMed  
    P29350 O60674 JAK2    HPRD  PubMed  
    P29350 P52333 JAK3    HPRD  PubMed  
    P29350 P35968 KDR    HPRD  PubMed  
    P29350 Q07666 KHDRBS1    HPRD  PubMed  
    P29350 P43628 KIR2DL3    HPRD  PubMed  
    P29350 KIR2DL5 KIR2DL5A    HPRD  PubMed  
    P29350 P10721 KIT    HPRD  PubMed  
    P29350 KLRA1 KLRAP1    HPRD  PubMed  
    P29350 Q12918 KLRB1    HPRD  PubMed  
    P29350 P26715 KLRC1    HPRD  PubMed  
    P29350 Q6GTX8 LAIR1    HPRD  PubMed  
    P29350 P06239 LCK    HPRD  PubMed  
    P29350 Q13094 LCP2    HPRD  PubMed  
    P29350 P42702 LIFR    HPRD  PubMed  
    P29350 Q8N423 LILRB2    HPRD  PubMed  
    P29350 Q8NHJ6 LILRB4    HPRD  PubMed  
    P29350 P07948 LYN    HPRD  PubMed  
    P29350 Q01362 MS4A2    HPRD  PubMed  
    P29350 P35579 MYH9    HPRD  PubMed  
    P29350 P29475 NOS1    HPRD  PubMed  
    P29350 Q9NWQ8 PAG1    HPRD  PubMed  
    P29350 P16284 PECAM1    HPRD  PubMed  
    P29350 P27986 PIK3R1    HPRD  PubMed  
    P29350 Q9UKJ1 PILRA    HPRD  PubMed  
    P29350 Paired immunoglobulin like type 2 receptor beta PILRB    HPRD  PubMed  
    P29350 P17252 PRKCA    HPRD  PubMed  
    P29350 Q05655 PRKCD    HPRD  PubMed  
    P29350 Q14289 PTK2B    HPRD  PubMed  
    P29350 Q06124 PTPN11    HPRD  PubMed  
    P29350 P29350 PTPN6    HPRD  PubMed  
    P29350 P08575 PTPRC    HPRD  PubMed  
    P29350 P08922 ROS1    HPRD  PubMed  
    P29350 P29353 SHC1    HPRD  PubMed  
    P29350 Q96LC7 SIGLEC10    HPRD  PubMed  
    P29350 Q96RL6 SIGLEC11    HPRD  PubMed  
    P29350 Q96PQ1 SIGLEC12    HPRD  PubMed  
    P29350 P78324 SIRPA    HPRD  PubMed  
    P29350 Q96DU3 SLAMF6    HPRD  PubMed  
    P29350 Q07889 SOS1    HPRD  PubMed  
    P29350 Q9UM82 SPATA2    HPRD  PubMed  
    P29350 P12931 SRC    HPRD  PubMed  
    P29350 P30874 SSTR2    HPRD  PubMed  
    P29350 P51692 STAT5B    HPRD  PubMed  
    P29350 P42226 STAT6    HPRD  PubMed  
    P29350 P43405 SYK    HPRD  PubMed  
    P29350 Q92734 TFG    HPRD  PubMed  
    P29350 Q9BXR5 TLR10    HPRD  PubMed  
    P29350 Q0P6H9 TMEM62    HPRD  PubMed  
    P29350 P19438 TNFRSF1A    HPRD  PubMed  
    P29350 Q9Y4K3 TRAF6    HPRD  PubMed  
    P29350 Q86YW5 TREML1    HPRD  PubMed  
    P29350 P29597 TYK2    HPRD  PubMed  
    P29350 P15498 VAV1    HPRD  PubMed  
    P29350 P43403 ZAP70    HPRD  PubMed  
    BioGRID:111742 BioGRID:106543 ABL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:107083 BCR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:118894 BLNK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:123283 C6orf25    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:107305 CAV1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:107315 CBL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:107371 CD22    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111742 BioGRID:107383 CD33    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111742 BioGRID:107359 CD5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:107409 CD72    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111742 BioGRID:107826 CSF2RB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111742 BioGRID:107881 CTNND1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111742 BioGRID:113607 CXCR4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:108276 EGFR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111742 BioGRID:108371 EPOR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111742 BioGRID:125428 FCRL3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111742 BioGRID:115181 GAB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:109142 GRB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:109446 HOXA10    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:111742 BioGRID:109780 IL4R    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111742 BioGRID:109786 IL6ST    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:109854 INSR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:109919 JAK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:111742 BioGRID:109920 JAK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:110015 KIT    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111742 BioGRID:110098 LAIR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111742 BioGRID:110124 LCK    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:111742 BioGRID:110129 LCP2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111742 BioGRID:110165 LIFR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:116070 LILRB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:115577 LILRB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:116197 LILRB4    BioGRID  PubMed Affinity Capture-Western; Protein-peptide 
    BioGRID:111742 BioGRID:110245 LYN    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111742 BioGRID:110905 NOS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:120931 PAG1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111742 BioGRID:111201 PECAM1    BioGRID  PubMed Affinity Capture-Western; Far Western; Reconstituted Complex 
    BioGRID:111742 BioGRID:111313 PIK3R1    BioGRID  PubMed Two-hybrid 
    BioGRID:111742 BioGRID:119017 PILRA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111742 BioGRID:111566 PRKCD    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:111742 BioGRID:108480 PTK2B    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111742 BioGRID:112025 ROS1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Two-hybrid 
    BioGRID:111742 BioGRID:125285 SIGLEC11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:126752 SIRPA    BioGRID  PubMed Co-crystal Structure; Two-hybrid 
    BioGRID:111742 BioGRID:125378 SLAMF6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:112537 SOS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:112630 SSTR2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:112654 STAT5B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:112717 SYK    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111742 BioGRID:131013 TREML1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111742 BioGRID:113148 TYK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111742 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111742 BioGRID:113252 VAV1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111742 BioGRID:113367 ZAP70    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • B cell receptor signaling pathway, conserved biosystem (from KEGG)
      B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • BCR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      BCR signaling pathway, organism-specific biosystem
      BCR signaling pathway
    • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR4-mediated signaling events, organism-specific biosystem
      CXCR4-mediated signaling events
    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Cell-Cell communication, organism-specific biosystem (from REACTOME)
      Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • EGF receptor (ErbB1) signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      EGF receptor (ErbB1) signaling pathway, organism-specific biosystem
      EGF receptor (ErbB1) signaling pathway
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • EPO signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      EPO signaling pathway, organism-specific biosystem
      EPO signaling pathway
    • Growth hormone receptor signaling, organism-specific biosystem (from REACTOME)
      Growth hormone receptor signaling, organism-specific biosystemGrowth hormone (Somatotropin or GH) is a key factor in determining lean body mass, stimulating the growth and metabolism of muscle, bone and cartilage cells, while reducing body fat. It has many othe...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-2 Signaling Pathway, organism-specific biosystemInterleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 ...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • IL-4 signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-4 signaling Pathway, organism-specific biosystemInterleukin-4 belongs to the IL-2 family of cytokines, which includes IL-2, IL-7, IL-9, IL-15 and IL-21. It signals through 2 different receptor complexes; Receptor complex 1 comprises of IL-4 recept...
    • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-5 Signaling Pathway, organism-specific biosystemInterleukin-5 belongs to the family of cytokines, which includes IL-3 and GM-CSF. It signals through a receptor complex comprising of an IL-5 receptor alpha subunit (IL5RA), and a common beta chain w...
    • IL4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL4-mediated signaling events, organism-specific biosystem
      IL4-mediated signaling events
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
      Interferon alpha/beta signaling, organism-specific biosystemType I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, wher...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    • Interleukin receptor SHC signaling, organism-specific biosystem (from REACTOME)
      Interleukin receptor SHC signaling, organism-specific biosystemPhosphorylation of Shc at three tyrosine residues, 239, 240 (Gotoh et al. 1996) and 317 (Salcini et al. 1994) involves unidentified tyrosine kinases presumed to be part of the activated receptor comp...
    • Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-2 signaling, organism-specific biosystemInterleukin-2 (IL-2) is a cytokine that is produced by T cells in response to antigen stimulation. Originally, IL-2 was discovered because of its potent growth factor activity on activated T cells in...
    • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
      Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemThe Interleukin-3 (IL-3), IL-5 and Granulocyte-macrophage colony stimulating factor (GM-CSF) receptors form a family of heterodimeric receptors that have specific alpha chains but share a common beta...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • PD-1 signaling, organism-specific biosystem (from REACTOME)
      PD-1 signaling, organism-specific biosystemThe Programmed cell death protein 1 (PD-1) is one of the negative regulators of TCR signaling. PD-1 may exert its effects on cell differentiation and survival directly by inhibiting early activation ...
    • PECAM1 interactions, organism-specific biosystem (from REACTOME)
      PECAM1 interactions, organism-specific biosystemPECAM-1/CD31 is a member of the immunoglobulin superfamily (IgSF) and has been implicated to mediate the adhesion and trans-endothelial migration of T-lymphocytes into the vascular wall, T cell activ...
    • Platelet homeostasis, organism-specific biosystem (from REACTOME)
      Platelet homeostasis, organism-specific biosystemUnder normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in charact...
    • Platelet sensitization by LDL, organism-specific biosystem (from REACTOME)
      Platelet sensitization by LDL, organism-specific biosystemPhysiological concentrations (1g/L) of Low density lipoprotein (LDL) enhance platelet aggregation responses initiated by thrombin, collagen, and ADP. This enhancement involves the rapid phosphorylati...
    • Regulation of IFNA signaling, organism-specific biosystem (from REACTOME)
      Regulation of IFNA signaling, organism-specific biosystemThere are several proteins and mechanisms involved in controlling the extent of ligand stimulation of IFNA/B signaling. These mechanisms can effect every step of the IFNA/B cascade. Dephosphorylation...
    • Regulation of IFNG signaling, organism-specific biosystem (from REACTOME)
      Regulation of IFNG signaling, organism-specific biosystemAt least three different classes of negative regulators exist to control the extent of INFG stimulation and signaling. These include the feedback inhibitors belonging to protein family suppressors of...
    • Regulation of KIT signaling, organism-specific biosystem (from REACTOME)
      Regulation of KIT signaling, organism-specific biosystemSCF induced proliferation is negatively regulated by various proteins including SHP1, PKC, CBL, SOCS1, SOCS6 and LNK.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signal regulatory protein (SIRP) family interactions, organism-specific biosystem (from REACTOME)
      Signal regulatory protein (SIRP) family interactions, organism-specific biosystemSignal regulatory protein (SIRP)alpha, also known as SHPS-1 or SIRPA or CD172a, is a transmembrane protein expressed mostly on myeloid cells. CD47, a widely expressed transmembrane protein, is a liga...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem
      Signaling events mediated by Stem cell factor receptor (c-Kit)
    • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
      Signaling events mediated by VEGFR1 and VEGFR2
    • T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      T Cell Receptor Signaling Pathway, organism-specific biosystem
      T Cell Receptor Signaling Pathway
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD4+ T cells, organism-specific biosystem
      TCR signaling in naive CD4+ T cells
    • TCR signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD8+ T cells, organism-specific biosystem
      TCR signaling in naive CD8+ T cells

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    		  
    transmembrane receptor protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    JAK-STAT cascade involved in growth hormone signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    T cell costimulation TAS
    Traceable Author Statement
    more info
    		  
    apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    leukocyte migration TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    peptidyl-tyrosine dephosphorylation TAS
    Traceable Author Statement
    more info
    		  
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of phosphatidylinositol 3-kinase cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    regulation of type I interferon-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    type I interferon-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    tyrosine-protein phosphatase non-receptor type 6
    Names
    tyrosine-protein phosphatase non-receptor type 6
    hematopoietic cell phosphatase
    protein-tyrosine phosphatase 1C
    protein-tyrosine phosphatase SHP-1
    hematopoietic cell protein-tyrosine phosphatase
    NP_002822.2
    NP_536858.1
    NP_536859.1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002831.5 → NP_002822.2  tyrosine-protein phosphatase non-receptor type 6 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes the shortest isoform (1, also known as SHP-1).
      Source sequence(s)
      AK290421, BC002523, DC297194
      Consensus CDS
      CCDS44820.1
      UniProtKB/Swiss-Prot
      P29350
      Related
      ENSP00000326010, OTTHUMP00000238912, ENST00000318974, OTTHUMT00000400023
      Conserved Domains (4) summary
      cd00047
      Location:272 – 514
      Blast Score: 782
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      smart00194
      Location:243 – 514
      Blast Score: 862
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd09931
      Location:109 – 215
      Blast Score: 457
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:3 – 101
      Blast Score: 489
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins

    2. NM_080548.4 → NP_536858.1  tyrosine-protein phosphatase non-receptor type 6 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' terminal exon compared to transcript variant 1, resulting in an isoform (2) with a distinct and longer (by 2 aa) N-terminus, compared to isoform 1.
      Source sequence(s)
      BC002523, DA431502
      Consensus CDS
      CCDS41744.1
      UniProtKB/Swiss-Prot
      P29350
      UniProtKB/TrEMBL
      Q53XS4
      Related
      ENSP00000382376, OTTHUMP00000238910, ENST00000399448, OTTHUMT00000400019
      Conserved Domains (4) summary
      cd00047
      Location:274 – 516
      Blast Score: 784
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      smart00194
      Location:245 – 516
      Blast Score: 864
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd09931
      Location:111 – 217
      Blast Score: 457
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:6 – 103
      Blast Score: 485
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins

    3. NM_080549.3 → NP_536859.1  tyrosine-protein phosphatase non-receptor type 6 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' terminal exon, and an alternate acceptor splice site at the penultimate exon, compared to transcript variant 1, resulting in a longer isoform (3, also known as 70 kDa SHP-1L protein) with distinct N_ and C_ termini, compared to isoform 1.
      Source sequence(s)
      AF178946, BC002523, BC007667, DC297194
      Consensus CDS
      CCDS44821.1
      UniProtKB/TrEMBL
      G3V0F8
      UniProtKB/Swiss-Prot
      P29350
      UniProtKB/TrEMBL
      Q9UK67
      Related
      ENSP00000391592, ENST00000456013
      Conserved Domains (4) summary
      cd00047
      Location:272 – 514
      Blast Score: 787
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      smart00194
      Location:243 – 514
      Blast Score: 868
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd09931
      Location:109 – 215
      Blast Score: 462
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:3 – 101
      Blast Score: 494
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      7055740..7070479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      6911844..6928943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB079851.1 BAC81774.1
      BAC81775.1
    genomic CH471116.2 EAW88700.1
      EAW88701.1
      EAW88702.1
      EAW88703.1
      EAW88704.1
    genomic HI573994.1 CBX47486.1
    genomic HI573996.1 CBX47487.1
    genomic U15528.1 AAA82879.1
      AAA82880.1
    genomic U15536.1 AAA82880.1
    genomic U15537.1 AAA82879.1
    genomic U47924.1 AAB51322.1
      AAB51323.1
    mRNA AF178946.1 AAD53317.1
    mRNA AK223629.1 BAD97349.1
    mRNA AK290421.1 BAF83110.1
    mRNA AK298470.1 BAG60682.1
    mRNA AK300167.1 BAG61949.1
    mRNA AK308230.1 None
    mRNA AK313379.1 BAG36177.1
    mRNA BC002523.2 AAH02523.1
    mRNA BC007667.2 AAH07667.1
    mRNA BG754792.1 None
    mRNA BM006699.1 None
    mRNA BM742181.1 None
    mRNA BT007390.1 AAP36054.1
    mRNA CR986427.1 None
    mRNA DA431502.1 None
    mRNA DA868001.1 None
    mRNA DC297194.1 None
    mRNA M74903.1 AAA35963.1
    mRNA M77273.1 AAA36610.1
    other-genetic DQ891946.2 ABM82872.1
    other-genetic DQ895133.2 ABM86059.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29350.1 GenPept UniProtKB/Swiss-Prot:P29350
    Q53EL0 GenPept UniProtKB/TrEMBL:Q53EL0
    Q53XS4 GenPept UniProtKB/TrEMBL:Q53XS4
    Q9UK67 GenPept UniProtKB/TrEMBL:Q9UK67
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
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