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    PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) [ Homo sapiens ]

    Gene ID: 5775, updated on 4-Feb-2012

    Summary

    Official Symbol
    PTPN4provided by HGNC
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)provided by HGNC
    Primary source
    HGNC:9656
    See related
    Ensembl:ENSG00000088179; HPRD:01471; MIM:176878; Vega:OTTHUMG00000131436
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PTPMEG; PTPMEG1
    Summary
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    2q14.2
    Sequence :
    Chromosome: 2; NC_000002.11 (120517207..120735037)
    See PTPN4 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 177 Neighboring gene ribosomal protein L17 pseudogene 15 Neighboring gene ribosomal protein L27 pseudogene 7 Neighboring gene erythrocyte membrane protein band 4.1 like 5

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P29074 P46100 ATRX    HPRD  PubMed  
    P29074 P68104 EEF1A1    HPRD  PubMed  
    P29074 P26641 EEF1G    HPRD  PubMed  
    P29074 O43424 GRID2    HPRD  PubMed  
    P29074 Q12879 GRIN2A    HPRD  PubMed  
    P29074 Q92993 KAT5    HPRD  PubMed  
    P29074 P06858 LPL    HPRD  PubMed  
    P29074 P07477 PRSS1    HPRD  PubMed  
    P29074 Zinc finger ZZ type with EF hand domain 1 ZZEF1    HPRD  PubMed  
    BioGRID:111741 BioGRID:107028 ATRX    BioGRID  PubMed Two-hybrid 
    BioGRID:111741 BioGRID:108237 EEF1A1    BioGRID  PubMed Two-hybrid 
    BioGRID:111741 BioGRID:108257 EEF1G    BioGRID  PubMed Two-hybrid 
    BioGRID:111741 BioGRID:109152 GRID2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111741 BioGRID:109160 GRIN2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111741 BioGRID:115779 KAT5    BioGRID  PubMed Two-hybrid 
    BioGRID:111741 BioGRID:110205 LPL    BioGRID  PubMed Two-hybrid 
    BioGRID:111741 BioGRID:110411 MGMT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111741 BioGRID:112938 TK1    BioGRID  PubMed Two-hybrid 
    BioGRID:111741 BioGRID:116757 ZZEF1    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    protein dephosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    internal side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein phosphatase non-receptor type 4
    Names
    tyrosine-protein phosphatase non-receptor type 4
    MEG
    PTPase-MEG1
    megakaryocyte phosphatase
    protein tyrosine phosphatase MEG1
    protein-tyrosine phosphatase MEG1
    megakaryocyte protein-tyrosine phosphatase
    NP_002821.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002830.2NP_002821.1  tyrosine-protein phosphatase non-receptor type 4

      Status: REVIEWED

      Source sequence(s)
      BC010674, M68941
      Consensus CDS
      CCDS2129.1
      UniProtKB/Swiss-Prot
      P29074
      Related
      ENSP00000263708, OTTHUMP00000162133, ENST00000263708, OTTHUMT00000254233
      Conserved Domains (8) summary
      cd00047
      Location:682909
      Blast Score: 780
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:515602
      Blast Score: 196
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd00836
      Location:217309
      Blast Score: 351
      FERM_C; FERM_C domain
      pfam08736
      Location:322365
      Blast Score: 150
      FA; FERM adjacent (FA)
      smart00194
      Location:657910
      Blast Score: 852
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:30222
      Blast Score: 571
      B41; Band 4.1 homologues
      pfam00373
      Location:117222
      Blast Score: 322
      FERM_M; FERM central domain
      pfam09379
      Location:33111
      Blast Score: 242
      FERM_N; FERM N-terminal domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      120517207..120735037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      112841586..113059439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC016691.10 AAX88858.1
    genomic AC069154.5 (163181..165131) None
    genomic AC092455.4 AAX82012.1
    genomic AC104061.5 None
    genomic AC104668.4 AAY24016.1
    genomic AC116632.3 AAY14805.1
    genomic CH471103.1 EAW95231.1
      EAW95232.1
    mRNA AK301218.1 BAH13435.1
    mRNA AK314836.1 BAG37355.1
    mRNA BC010674.1 AAH10674.1
    mRNA BX648614.1 None
    mRNA M68941.1 AAA36530.1
    other-genetic JF432311.1 ADZ15528.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P29074.1 GenPept UniProtKB/Swiss-Prot:P29074
    Q4ZG31 GenPept UniProtKB/TrEMBL:Q4ZG31
    Q53Q76 GenPept UniProtKB/TrEMBL:Q53Q76
    Q53QV5 GenPept UniProtKB/TrEMBL:Q53QV5
    Q580X3 GenPept UniProtKB/TrEMBL:Q580X3

      Supplemental Content

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