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PTPN3 protein tyrosine phosphatase, non-receptor type 3 [ Homo sapiens (human) ]

Gene ID: 5774, updated on 12-May-2016
Official Symbol
PTPN3provided by HGNC
Official Full Name
protein tyrosine phosphatase, non-receptor type 3provided by HGNC
Primary source
HGNC:HGNC:9655
See related
Ensembl:ENSG00000070159 HPRD:06767; MIM:176877; Vega:OTTHUMG00000020475
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTPH1; PTP-H1
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Orthologs
Location:
9q31
Exon count:
32
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (109375694..109538353, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (112137974..112260593, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ferric chelate reductase 1 like Neighboring gene erythrocyte membrane protein band 4.1 like 4B Neighboring gene mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 pseudogene 11 Neighboring gene microRNA 3927 Neighboring gene Y-box binding protein 1 pseudogene 6 Neighboring gene paralemmin 2 Neighboring gene PALM2-AKAP2 readthrough Neighboring gene ribosomal protein L21 pseudogene 87

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp686N0569

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 
phosphotyrosine binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
sodium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tyrosine-protein phosphatase non-receptor type 3
Names
cytoskeletal-associated protein tyrosine phosphatase
protein-tyrosine phosphatase H1
NP_001138840.1
NP_001138841.1
NP_001138842.1
NP_001138843.1
NP_001138844.1
NP_002820.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047071.1 RefSeqGene

    Range
    45041..167660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145368.1NP_001138840.1  tyrosine-protein phosphatase non-receptor type 3 isoform 2

    See identical proteins and their annotated locations for NP_001138840.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing an in-frame coding exon compared to transcript variant 1, resulting in a shorter isoform (2) lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AK096975, AK316066, AL359963, BC033716, BC126117, BU624870, DB173093
    UniProtKB/Swiss-Prot
    P26045
    UniProtKB/TrEMBL
    B7Z9V1, Q8N4S3
    Conserved Domains (7) summary
    smart00194
    Location:604855
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:31222
    B41; Band 4.1 homologues
    cd00047
    Location:627854
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:463550
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09379
    Location:33111
    FERM_N; FERM N-terminal domain
    cd13189
    Location:216309
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14473
    Location:122214
    FERM_B-lobe; FERM domain B-lobe
  2. NM_001145369.1NP_001138841.1  tyrosine-protein phosphatase non-receptor type 3 isoform 3

    See identical proteins and their annotated locations for NP_001138841.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and initiates translation from an in-frame downstream AUG, resulting in an isoform (3) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK096975, AL162733, AL359963, BU624870, BX648253, BX648735, DB173093, DB306298
    Consensus CDS
    CCDS48001.1
    UniProtKB/Swiss-Prot
    P26045
    Related
    ENSP00000416654, ENST00000412145
    Conserved Domains (6) summary
    smart00194
    Location:518769
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:291
    B41; Band 4.1 homologues
    cd00047
    Location:541768
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:377464
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:85178
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14473
    Location:283
    FERM_B-lobe; FERM domain B-lobe
  3. NM_001145370.1NP_001138842.1  tyrosine-protein phosphatase non-receptor type 3 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, and is missing an in-frame coding exon compared to transcript variant 1, resulting in an isoform (4) with a shorter N-terminus and lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AK096975, AL162733, AL359963, BU624870, BX648253, BX648735, DB173093, DB306298
    Consensus CDS
    CCDS48000.1
    UniProtKB/Swiss-Prot
    P26045
    Related
    ENSP00000395384, ENST00000446349
    Conserved Domains (6) summary
    smart00194
    Location:473724
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:291
    B41; Band 4.1 homologues
    cd00047
    Location:496723
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:332419
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:85178
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14473
    Location:283
    FERM_B-lobe; FERM domain B-lobe
  4. NM_001145371.1NP_001138843.1  tyrosine-protein phosphatase non-receptor type 3 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, and initiates translation from an in-frame downstream AUG, resulting in an isoform (5) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK096975, AK296388, AL359963, BC033716, BC126117, BU624870, DB173093, DC342461
    UniProtKB/Swiss-Prot
    P26045
    UniProtKB/TrEMBL
    B7Z3V3, Q8N4S3
    Conserved Domains (4) summary
    smart00194
    Location:362613
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:385612
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:221308
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl17171
    Location:122
    PH-like; Pleckstrin homology-like domain
  5. NM_001145372.1NP_001138844.1  tyrosine-protein phosphatase non-receptor type 3 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, and is missing an in-frame coding exon compared to transcript variant 1, resulting in an isoform (6) with a shorter N-terminus and lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AK096975, AK316118, AL359963, BC033716, BU624870, DB173093, DC342461
    UniProtKB/TrEMBL
    B7ZA03, Q8N4S3
    Conserved Domains (4) summary
    smart00194
    Location:317568
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:340567
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:176263
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl17171
    Location:122
    PH-like; Pleckstrin homology-like domain
  6. NM_002829.3NP_002820.3  tyrosine-protein phosphatase non-receptor type 3 isoform 1

    See identical proteins and their annotated locations for NP_002820.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK096975, AK316066, AL359963, BC033716, BC126117, BU624870, DB173093
    Consensus CDS
    CCDS6776.1
    UniProtKB/Swiss-Prot
    P26045
    UniProtKB/TrEMBL
    B7Z9V1, Q8N4S3
    Related
    ENSP00000363667, OTTHUMP00000021885, ENST00000374541, OTTHUMT00000053598
    Conserved Domains (7) summary
    smart00194
    Location:649900
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:31222
    B41; Band 4.1 homologues
    cd00047
    Location:672899
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:508595
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09379
    Location:33111
    FERM_N; FERM N-terminal domain
    cd13189
    Location:216309
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14473
    Location:122214
    FERM_B-lobe; FERM domain B-lobe

RNA

  1. NR_026918.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains an alternate 5' terminal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK096975, AK303608, AL359963, BC033716, BU624870, DB173093

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    109375694..109538353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518890.1XP_011517192.1  

    Conserved Domains (7) summary
    smart00194
    Location:625876
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:52243
    B41; Band 4.1 homologues
    cd00047
    Location:648875
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:484571
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09379
    Location:54132
    FERM_N; FERM N-terminal domain
    cd13189
    Location:237330
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14473
    Location:143235
    FERM_B-lobe; FERM domain B-lobe
  2. XM_011518888.1XP_011517190.1  

    Conserved Domains (7) summary
    smart00194
    Location:670921
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:52243
    B41; Band 4.1 homologues
    cd00047
    Location:693920
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:529616
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09379
    Location:54132
    FERM_N; FERM N-terminal domain
    cd13189
    Location:237330
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14473
    Location:143235
    FERM_B-lobe; FERM domain B-lobe
  3. XM_011518889.1XP_011517191.1  

    See identical proteins and their annotated locations for XP_011517191.1

    UniProtKB/Swiss-Prot
    P26045
    Conserved Domains (7) summary
    smart00194
    Location:649900
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:31222
    B41; Band 4.1 homologues
    cd00047
    Location:672899
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:508595
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09379
    Location:33111
    FERM_N; FERM N-terminal domain
    cd13189
    Location:216309
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14473
    Location:122214
    FERM_B-lobe; FERM domain B-lobe
  4. XM_006717201.2XP_006717264.1  

    Conserved Domains (6) summary
    smart00194
    Location:540791
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:9113
    B41; Band 4.1 homologues
    cd00047
    Location:563790
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:399486
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:107200
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14473
    Location:14105
    FERM_B-lobe; FERM domain B-lobe
  5. XM_006717204.2XP_006717267.1  

    See identical proteins and their annotated locations for XP_006717267.1

    UniProtKB/Swiss-Prot
    P26045
    Conserved Domains (6) summary
    smart00194
    Location:518769
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:291
    B41; Band 4.1 homologues
    cd00047
    Location:541768
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:377464
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:85178
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14473
    Location:283
    FERM_B-lobe; FERM domain B-lobe
  6. XM_006717199.2XP_006717262.1  

    See identical proteins and their annotated locations for XP_006717262.1

    UniProtKB/Swiss-Prot
    P26045
    Conserved Domains (7) summary
    smart00194
    Location:649900
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:31222
    B41; Band 4.1 homologues
    cd00047
    Location:672899
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:508595
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09379
    Location:33111
    FERM_N; FERM N-terminal domain
    cd13189
    Location:216309
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14473
    Location:122214
    FERM_B-lobe; FERM domain B-lobe
  7. XM_006717197.2XP_006717260.1  

    Conserved Domains (7) summary
    smart00194
    Location:660911
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:42233
    B41; Band 4.1 homologues
    cd00047
    Location:683910
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:519606
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09379
    Location:44122
    FERM_N; FERM N-terminal domain
    cd13189
    Location:227320
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14473
    Location:133225
    FERM_B-lobe; FERM domain B-lobe
  8. XM_006717202.2XP_006717265.1  

    See identical proteins and their annotated locations for XP_006717265.1

    Conserved Domains (6) summary
    smart00194
    Location:534785
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:6107
    B41; Band 4.1 homologues
    cd00047
    Location:557784
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:393480
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:101194
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14473
    Location:899
    FERM_B-lobe; FERM domain B-lobe
  9. XM_006717203.2XP_006717266.1  

    See identical proteins and their annotated locations for XP_006717266.1

    Conserved Domains (6) summary
    smart00194
    Location:534785
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:6107
    B41; Band 4.1 homologues
    cd00047
    Location:557784
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:393480
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:101194
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14473
    Location:899
    FERM_B-lobe; FERM domain B-lobe

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    112284708..112407241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)