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    ZFYVE28 zinc finger, FYVE domain containing 28 [ Homo sapiens ]

    Gene ID: 57732, updated on 11-May-2012
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    Summary

    Official Symbol
    ZFYVE28provided by HGNC
    Official Full Name
    zinc finger, FYVE domain containing 28provided by HGNC
    Primary source
    HGNC:29334
    See related
    Ensembl:ENSG00000159733; HPRD:11701; MIM:614176; Vega:OTTHUMG00000160292
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LST2; LYST2; MGC43699; MGC61592
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    Genomic context

    Location :
    4p16.3
    Sequence :
    Chromosome: 4; NC_000004.11 (2271324..2420370, complement)
    See ZFYVE28 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) pseudogene 5 Neighboring gene HAUS augmin-like complex, subunit 3 Neighboring gene microRNA 4800 Neighboring gene MAX dimerization protein 4 Neighboring gene Spi-C transcription factor (Spi-1/PU.1 related) pseudogene Neighboring gene uncharacterized LOC402160 Neighboring gene ring finger protein 4

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    5. Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling. Mosesson Y, et al. Dev Cell, 2009 May. PMID 19460345.

    See all (8) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. Study concludes that endosomal localization of Lst2 (ZFYVE28), along with an ability to divert incoming EGFR molecules to degradation in lysosomes, is regulated by ubiquitinylation/deubiquitinylation cycles.
      Title: Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:121752 BioGRID:108270 EGF    BioGRID  PubMed Co-localization 
    BioGRID:121752 BioGRID:108276 EGFR    BioGRID  PubMed Co-localization 
    BioGRID:121752 BioGRID:111805 RAB4A    BioGRID  PubMed Co-localization 
    BioGRID:121752 BioGRID:111806 RAB5A    BioGRID  PubMed Co-localization 
    BioGRID:121752 BioGRID:113624 RAB7A    BioGRID  PubMed Co-localization 
    BioGRID:121752 BioGRID:207763 Trim3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:121752 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    negative regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of epidermal growth factor-activated receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    early endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    lateral signaling target protein 2 homolog
    Names
    lateral signaling target protein 2 homolog
    hLst2
    zinc finger FYVE domain-containing protein 28
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172656.1 → NP_001166127.1  lateral signaling target protein 2 homolog isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, uses an upstream start codon, and lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (3) has a longer N-terminus and lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AB046863, AK293775, AK294710, BC032605, BC137309, BM128958
      Consensus CDS
      CCDS54711.1
      UniProtKB/Swiss-Prot
      Q9HCC9
      Related
      ENSP00000425706, OTTHUMP00000217955, ENST00000511071, OTTHUMT00000360079
      Conserved Domains (2) summary
      cd00065
      Location:790 – 843
      Blast Score: 215
      FYVE; FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1;
      pfam01363
      Location:782 – 843
      Blast Score: 257
      FYVE; FYVE zinc finger

    2. NM_001172657.1 → NP_001166128.1  lateral signaling target protein 2 homolog isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter and 5' UTR, uses an upstream start codon, and uses an alternate 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (4) has a longer N-terminus and a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL158068, BC032605, BC053664
      Consensus CDS
      CCDS54712.1
      UniProtKB/TrEMBL
      E9PG77
      UniProtKB/TrEMBL
      Q7Z6J3
      Related
      ENSP00000423694, OTTHUMP00000217956, ENST00000503000, OTTHUMT00000360080

    3. NM_001172658.1 → NP_001166129.1  lateral signaling target protein 2 homolog isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents use of an alternate promoter and 5' UTR, uses an upstream start codon, and uses an alternate 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (5) has a longer N-terminus and a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC032605, BC035793, BC137310
      Consensus CDS
      CCDS54710.1
      UniProtKB/TrEMBL
      E9PB54
      UniProtKB/Swiss-Prot
      Q9HCC9
      Related
      ENSP00000422638, OTTHUMP00000217960, ENST00000509171, OTTHUMT00000360085

    4. NM_001172659.1 → NP_001166130.1  lateral signaling target protein 2 homolog isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AB046863, AK294874, AK316484, BC035793, BC137310, BM128958
      Consensus CDS
      CCDS54708.1
      UniProtKB/Swiss-Prot
      Q9HCC9
      Related
      ENSP00000426299, OTTHUMP00000217958, ENST00000515312, OTTHUMT00000360083
      Conserved Domains (2) summary
      cd00065
      Location:750 – 803
      Blast Score: 216
      FYVE; FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1;
      pfam01363
      Location:742 – 803
      Blast Score: 258
      FYVE; FYVE zinc finger

    5. NM_001172660.1 → NP_001166131.1  lateral signaling target protein 2 homolog isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (6) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK316484, BC035793, BC137310
      Consensus CDS
      CCDS54709.1
      UniProtKB/TrEMBL
      E9PB64
      UniProtKB/Swiss-Prot
      Q9HCC9
      Related
      ENSP00000425766, OTTHUMP00000217959, ENST00000515169, OTTHUMT00000360084

    6. NM_020972.2 → NP_066023.2  lateral signaling target protein 2 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses an upstream start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1.
      Source sequence(s)
      AB046863, AK294874, BC032605, BC137310, BM128958
      Consensus CDS
      CCDS33942.1
      UniProtKB/Swiss-Prot
      Q9HCC9
      Related
      ENSP00000290974, OTTHUMP00000217954, ENST00000290974, OTTHUMT00000360078
      Conserved Domains (2) summary
      cd00065
      Location:820 – 873
      Blast Score: 216
      FYVE; FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1;
      pfam01363
      Location:812 – 873
      Blast Score: 258
      FYVE; FYVE zinc finger

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      2271324..2420370, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      2212291..2360820, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL158068.18 (2000..80410) None
    genomic AL645924.13 (98049..168682) None
    genomic CH471131.2 EAW82528.1
      EAW82529.1
    mRNA AB046863.1 BAB13469.1
    mRNA AK126692.1 BAG54362.1
    mRNA AK293775.1 BAH11593.1
    mRNA AK294710.1 BAH11855.1
    mRNA AK294874.1 BAH11908.1
    mRNA AK316484.1 BAH14855.1
    mRNA BC032605.1 None
    mRNA BC035793.1 None
    mRNA BC041866.1 AAH41866.1
    mRNA BC053664.1 AAH53664.1
    mRNA BC137309.1 AAI37310.1
    mRNA BC137310.1 AAI37311.1
    mRNA BM128958.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q49AA1 GenPept UniProtKB/TrEMBL:Q49AA1
    Q7Z6J3 GenPept UniProtKB/TrEMBL:Q7Z6J3
    Q9HCC9.3 GenPept UniProtKB/Swiss-Prot:Q9HCC9
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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