PTPN1 protein tyrosine phosphatase, non-receptor type 1 [Homo sapiens] - Gene

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Summary

Official Symbol: PTPN1provided by HGNC
Official Full Name: protein tyrosine phosphatase, non-receptor type 1provided by HGNC
Primary source: HGNC:9642
See related: Ensembl:ENSG00000196396; HPRD:01477; MIM:176885; Vega:OTTHUMG00000032729
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PTP1B
Summary: The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 20q13.1-q13.2

Sequence :: Chromosome: 20; NC_000020.10 (49126891..49201088)

See PTPN1 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In glioblastoma PTPIP51 expression increases with the grade of malignancy and PTPIP51 interacts in situ with 14-3-3ss and PTP1B.
Title: PTPIP51, a positive modulator of the MAPK/Erk pathway, is upregulated in glioblastoma and interacts with 14-3-3β and PTP1B in situ.
The biological buffer bicarbonate/CO(2) potentiates the ability of H(2)O(2) to inactivate PTP1B.
Title: The biological buffer bicarbonate/CO2 potentiates H2O2-mediated inactivation of protein tyrosine phosphatases.
Lack of association of PTPN1 gene polymorphisms with type 2 diabetes in south Indians
Title: Lack of association of PTPN1 gene polymorphisms with type 2 diabetes in south Indians.
inhibition of PTP1B may be a useful strategy to explore in the development of novel therapeutic agents for the treatment of CML, particularly because host drugs currently used in CML such as imatinib focus on inhibiting the kinase activity of Bcr-Abl.
Title: Inhibition of protein-tyrosine phosphatase 1B (PTP1B) mediates ubiquitination and degradation of Bcr-Abl protein.
PTPIP51 is phosphorylated by Lyn and c-Src kinases lacking dephosphorylation by PTP1B in acute myeloid leukemia.
Title: PTPIP51 is phosphorylated by Lyn and c-Src kinases lacking dephosphorylation by PTP1B in acute myeloid leukemia.
Studies reveal for the first time that the adaptor protein Dock/Nck attenuates insulin signalling by recruiting PTP61F/PTP1B to its substrate, the IR.
Title: Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling.
Results suggest that a HIF-regulated VHL-PTP1B-Src signaling pathway determines the sensitivity of RCC to Src inhibitors.
Title: A HIF-regulated VHL-PTP1B-Src signaling axis identifies a therapeutic target in renal cell carcinoma.
PTP1B plays a crucial role in the control of the activity of the IR precursor during its biosynthesis. In addition, this new substrate-trapping mutant may be a valuable tool for the identification of new PTP1B substrates.
Title: A new highly efficient substrate-trapping mutant of protein tyrosine phosphatase 1B (PTP1B) reveals full autoactivation of the insulin receptor precursor.
PTP1B gene Pro303Pro polymorphism might be associated with the pathogenesis of obesity in children and could affect lipid metabolism in obese Chinese children.
Title: Association of PTP1B gene polymorphism with obesity in Chinese children.
Data demonstrated that the increased expression of DUOX1 in IL-4/IL-13-treated NHEK augments STAT6 phosphorylation via oxidative inactivation of protein tyrosine phosphatase 1B.
Title: Dual oxidase 1 induced by Th2 cytokines promotes STAT6 phosphorylation via oxidative inactivation of protein tyrosine phosphatase 1B in human epidermal keratinocytes.

Submit: New GeneRIF Correction See all (97)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

Insulin resistance, susceptibility to

MIM: 176885

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_002818.1	NP_001744.2	CAV1	BIND	PubMed	caveolin-1 interacts with PTP1B.
P18031	P12814	ACTN1	HPRD	PubMed
P18031	P31749	AKT1	HPRD	PubMed
P18031	P56945	BCAR1	HPRD	PubMed
P18031	P11274	BCR	HPRD	PubMed
P18031	P17655	CAPN2	HPRD	PubMed
P18031	Q03135	CAV1	HPRD	PubMed
P18031	P19022	CDH2	HPRD	PubMed
P18031	P06493	CDK1	HPRD	PubMed
P18031	P49759	CLK1	HPRD	PubMed
P18031	P49760	CLK2	HPRD	PubMed
P18031	P68400	CSNK2A1	HPRD	PubMed
P18031	P19784	CSNK2A2	HPRD	PubMed
P18031	P35222	CTNNB1	HPRD	PubMed
P18031	P00533	EGFR	HPRD	PubMed
P18031	P03372	ESR1	HPRD	PubMed
P18031	P35754	GLRX	HPRD	PubMed
P18031	P62993	GRB2	HPRD	PubMed
P18031	P49841	GSK3B	HPRD	PubMed
P18031	P08069	IGF1R	HPRD	PubMed
P18031	P06213	INSR	HPRD	PubMed
P18031	P35568	IRS1	HPRD	PubMed
P18031	O60674	JAK2	HPRD	PubMed
P18031	O43561	LAT	HPRD	PubMed
P18031	P29376	LTK	HPRD	PubMed
P18031	P28482	MAPK1	HPRD	PubMed
P18031	P25963	NFKBIA	HPRD	PubMed
P18031	P04629	NTRK1	HPRD	PubMed
P18031	Q16620	NTRK2	HPRD	PubMed
P18031	Q16288	NTRK3	HPRD	PubMed
P18031	P09619	PDGFRB	HPRD	PubMed
P18031	O75925	PIAS1	HPRD	PubMed
P18031	Q13526	PIN1	HPRD	PubMed
P18031	P62070	RRAS2	HPRD	PubMed
P18031	P12931	SRC	HPRD	PubMed
P18031	P42229	STAT5A	HPRD	PubMed
P18031	P51692	STAT5B	HPRD	PubMed
P18031	Q9H1D0	TRPV6	HPRD	PubMed
P18031	P29597	TYK2	HPRD	PubMed
BioGRID:111736	BioGRID:114934	BCAR1	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; Reconstituted Complex
BioGRID:111736	BioGRID:107305	CAV1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111736	BioGRID:107788	CRK	BioGRID	PubMed	Reconstituted Complex
BioGRID:111736	BioGRID:107880	CTNNB1	BioGRID	PubMed	Reconstituted Complex
BioGRID:111736	BioGRID:108276	EGFR	BioGRID	PubMed	Biochemical Activity; Co-crystal Structure
BioGRID:111736	BioGRID:108957	GHR	BioGRID	PubMed	Far Western; Reconstituted Complex
BioGRID:111736	BioGRID:109142	GRB2	BioGRID	PubMed	Reconstituted Complex
BioGRID:111736	BioGRID:109187	GSK3B	BioGRID	PubMed	Biochemical Activity
BioGRID:111736	BioGRID:109701	IGF1R	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111736	BioGRID:109854	INSR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111736	BioGRID:109874	IRS1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111736	BioGRID:109920	JAK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111736	BioGRID:110236	LTK	BioGRID	PubMed	Protein-peptide
BioGRID:111736	BioGRID:110969	NTRK1	BioGRID	PubMed	Protein-peptide
BioGRID:111736	BioGRID:110970	NTRK2	BioGRID	PubMed	Protein-peptide
BioGRID:111736	BioGRID:110971	NTRK3	BioGRID	PubMed	Protein-peptide
BioGRID:111736	BioGRID:112653	STAT5A	BioGRID	PubMed	Protein-peptide
BioGRID:111736	BioGRID:112654	STAT5B	BioGRID	PubMed	Protein-peptide
BioGRID:111736	BioGRID:113148	TYK2	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
ephrin receptor binding	IPI Inferred from Physical Interaction more info
hydrolase activity	IEA Inferred from Electronic Annotation more info
insulin receptor binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
protein tyrosine phosphatase activity	TAS Traceable Author Statement more info
zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
JAK-STAT cascade involved in growth hormone signaling pathway	TAS Traceable Author Statement more info
actin cytoskeleton reorganization	IMP Inferred from Mutant Phenotype more info
blood coagulation	TAS Traceable Author Statement more info
cytokine-mediated signaling pathway	TAS Traceable Author Statement more info
interferon-gamma-mediated signaling pathway	TAS Traceable Author Statement more info
negative regulation of insulin receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
peptidyl-tyrosine dephosphorylation	IDA Inferred from Direct Assay more info
peptidyl-tyrosine dephosphorylation	TAS Traceable Author Statement more info
platelet activation	TAS Traceable Author Statement more info
regulation of endocytosis	IDA Inferred from Direct Assay more info
regulation of interferon-gamma-mediated signaling pathway	TAS Traceable Author Statement more info
regulation of signal transduction	IMP Inferred from Mutant Phenotype more info
regulation of type I interferon-mediated signaling pathway	TAS Traceable Author Statement more info
type I interferon-mediated signaling pathway	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info
early endosome	IDA Inferred from Direct Assay more info
endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
insoluble fraction	IEA Inferred from Electronic Annotation more info
colocalizes_with plasma membrane	IDA Inferred from Direct Assay more info

General protein information

Preferred Names: tyrosine-protein phosphatase non-receptor type 1

Names: tyrosine-protein phosphatase non-receptor type 1; protein tyrosine phosphatase 1B; protein-tyrosine phosphatase 1B; protein tyrosine phosphatase, placental

NP_002818.1

EC 3.1.3.48

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012119.1 RefSeqGene

Range

5001..79198

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002827.2 → NP_002818.1 tyrosine-protein phosphatase non-receptor type 1

Status: REVIEWED

Source sequence(s)

AU117677, M33689

Consensus CDS

CCDS13430.1

UniProtKB/TrEMBL

A8K3M3

UniProtKB/Swiss-Prot

P18031

Related

ENSP00000360683, OTTHUMP00000031266, ENST00000371621, OTTHUMT00000079694

Conserved Domains (2) summary

cd00047
Location:43 – 276
Blast Score: 759

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

smart00194
Location:3 – 276
Blast Score: 860

PTPc; Protein tyrosine phosphatase, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p5 Primary Assembly

Range

49126891..49201088

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

45875618..45949850

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL034429.1	CAI23215.1
genomic	AL133230.25	CAC00618.2
genomic	AY029236.1	AAK31734.1
genomic	CH471077.2	EAW75624.1
		EAW75625.1
		EAW75626.1
genomic	CS569123.1	CAN59693.1
genomic	HD122567.1	CBW46546.1
genomic	HI639118.1	CBX55888.1
genomic	JA420824.1	CCD32728.1
genomic	M33684.1	AAA60158.1
mRNA	AK290638.1	BAF83327.1
mRNA	AK299830.1	BAG61697.1
mRNA	AK316563.1	BAG38152.1
mRNA	AU117677.1	None
mRNA	BC015660.2	AAH15660.1
mRNA	BC018164.1	AAH18164.1
mRNA	BT006752.1	AAP35398.1
mRNA	M31724.1	AAA60223.1
mRNA	M33689.1	AAA60157.1