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USP28 ubiquitin specific peptidase 28 [ Homo sapiens (human) ]

Gene ID: 57646, updated on 8-May-2016
Official Symbol
USP28provided by HGNC
Official Full Name
ubiquitin specific peptidase 28provided by HGNC
Primary source
HGNC:HGNC:12625
See related
Ensembl:ENSG00000048028 HPRD:15632; MIM:610748; Vega:OTTHUMG00000168205
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (Valero et al., 2001).[supplied by OMIM, Mar 2008]
Orthologs
Location:
11q23
Exon count:
29
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (113797875..113875570, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (113668597..113746292, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene claudin 25 Neighboring gene SH3 domain containing GRB2 like 1 pseudogene Neighboring gene activating transcription factor 4 pseudogene 4 Neighboring gene interferon stimulated exonuclease gene 20kDa like 2 pseudogene Neighboring gene 5-hydroxytryptamine receptor 3B Neighboring gene 5-hydroxytryptamine receptor 3A

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • KIAA1515

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ionizing radiation IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
ubiquitin carboxyl-terminal hydrolase 28
Names
deubiquitinating enzyme 28
ubiquitin carboxyl-terminal hydrolase 28 variant 1
ubiquitin specific protease 28
ubiquitin thioesterase 28
ubiquitin thiolesterase 28
ubiquitin-specific-processing protease 28
NP_001287958.1
NP_065937.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301029.1NP_001287958.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 2

    See identical proteins and their annotated locations for NP_001287958.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons in the 5' end and an alternate in-frame exon in the 3' end compared to variant 1. The resulting isoform (2) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AK304770, AP003170, BC035986, BF434481, DB061316
    Consensus CDS
    CCDS73394.1
    UniProtKB/TrEMBL
    B4E3L3
    Related
    ENSP00000444991, OTTHUMP00000238297, ENST00000545540, OTTHUMT00000398791
    Conserved Domains (3) summary
    cd02665
    Location:38523
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:36278
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl02553
    Location:38142
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  2. NM_020886.3NP_065937.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 1

    See identical proteins and their annotated locations for NP_065937.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF266283, AP003170, BC035986, BF434481, DB061316
    Consensus CDS
    CCDS31680.1
    UniProtKB/Swiss-Prot
    Q96RU2
    Related
    ENSP00000003302, OTTHUMP00000238295, ENST00000003302, OTTHUMT00000398789
    Conserved Domains (4) summary
    cd02665
    Location:163648
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:161403
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cd14355
    Location:2364
    UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
    cl02553
    Location:163267
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    113797875..113875570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542938.1XP_011541240.1  

    Conserved Domains (3) summary
    cd02665
    Location:38524
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:36279
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl02553
    Location:38142
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  2. XM_011542937.1XP_011541239.1  

    Conserved Domains (3) summary
    cd02665
    Location:163620
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:161375
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cd14355
    Location:2364
    UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
  3. XM_005271639.2XP_005271696.1  

    See identical proteins and their annotated locations for XP_005271696.1

    UniProtKB/Swiss-Prot
    Q96RU2
    Conserved Domains (4) summary
    cd02665
    Location:163648
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:161403
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cd14355
    Location:2364
    UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
    cl02553
    Location:163267
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  4. XM_005271631.2XP_005271688.1  

    Conserved Domains (4) summary
    cd02665
    Location:163648
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:161403
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cd14355
    Location:2364
    UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
    cl02553
    Location:163267
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  5. XM_005271636.2XP_005271693.1  

    Conserved Domains (3) summary
    cd02665
    Location:163589
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:161588
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cd14355
    Location:2364
    UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
  6. XM_005271638.2XP_005271695.1  

    Conserved Domains (4) summary
    cd02665
    Location:163649
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:161404
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cd14355
    Location:2364
    UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
    cl02553
    Location:163267
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  7. XM_005271637.2XP_005271694.1  

    Conserved Domains (4) summary
    cd02665
    Location:163649
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:161404
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cd14355
    Location:2364
    UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
    cl02553
    Location:163267
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  8. XM_005271630.2XP_005271687.1  

    Conserved Domains (4) summary
    cd02665
    Location:163649
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:161404
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cd14355
    Location:2364
    UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
    cl02553
    Location:163267
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  9. XM_005271632.2XP_005271689.1  

    Conserved Domains (4) summary
    cd02665
    Location:160646
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:158401
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cd14355
    Location:2061
    UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
    cl02553
    Location:160264
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  10. XM_011542936.1XP_011541238.1  

    Conserved Domains (3) summary
    cd02665
    Location:137623
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:135378
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl02553
    Location:137241
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  11. XM_011542939.1XP_011541241.1  

    Conserved Domains (2) summary
    cd02665
    Location:38494
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:36249
    UCH; Ubiquitin carboxyl-terminal hydrolase
  12. XM_005271633.3XP_005271690.1  

    Conserved Domains (4) summary
    cd02665
    Location:141627
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:139382
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cd14355
    Location:142
    UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
    cl02553
    Location:141245
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  13. XM_011542940.1XP_011541242.1  

    Related
    ENSP00000442431, OTTHUMP00000238296, ENST00000544967, OTTHUMT00000398790
    Conserved Domains (1) summary
    cd02665
    Location:1361
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
  14. XM_011542941.1XP_011541243.1  

    Conserved Domains (1) summary
    cl02553
    Location:148296
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  15. XM_011542942.1XP_011541244.1  

    Conserved Domains (1) summary
    cl02553
    Location:57205
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    113551888..113629866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)