PTN pleiotrophin [ Homo sapiens ]

Gene ID: 5764, updated on 11-May-2012

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Summary

Official Symbol: PTNprovided by HGNC
Official Full Name: pleiotrophinprovided by HGNC
Primary source: HGNC:9630
See related: Ensembl:ENSG00000105894; HPRD:01199; MIM:162095; Vega:OTTHUMG00000155709
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HARP; HBNF; HBGF8; NEGF1

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Genomic context

Location :: 7q33

Sequence :: Chromosome: 7; NC_000007.13 (136912088..137028546, complement)

See PTN in Epigenomics, MapViewer

Chromosome 7 - NC_000007.13 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study shows that PTN expression is upregulated in a mouse model of peritoneal fibrosis and is present in human peritoneal tissues and in peritoneal dialysate effluent.
Title: Pleiotrophin triggers inflammation and increased peritoneal permeability leading to peritoneal fibrosis.
in postmenopausal women, the PTN gene promoter polymorphism -1227C>T and CT haplotype could contribute to the genetic background of osteoporosis.
Title: -1227C>T polymorphism in the pleiotrophin gene promoter influences bone mineral density in postmenopausal women.
in the prostate pleiotrophin (Ptn) functions as a regulator of both mesenchymal and epithelial proliferation, and that androgens regulate Ptn levels.
Title: Expression of pleiotrophin in the prostate is androgen regulated and it functions as an autocrine regulator of mesenchyme and cancer associated fibroblasts and as a paracrine regulator of epithelia.
results demonstrate that P(122-131) inhibits biological activities that are related to the induction of a transformed phenotype in PCa cells, by interacing with RPTPbeta-zeta and interfering with other pleiotrophin receptors
Title: A Pleiotrophin C-terminus peptide induces anti-cancer effects through RPTPβ/ζ.
The role of PTN and its involvement in tumor growth and angiogenesis, is summarized.
Title: Roles of pleiotrophin in tumor growth and angiogenesis.
molecular mechanism of the interactions between the oligosaccharides and pleiotrophin
Title: Structure of pleiotrophin- and hepatocyte growth factor-binding sulfated hexasaccharide determined by biochemical and computational approaches.
Overexpression of pleiotrophin is associated with glioblastoma.
Title: Antitumorigenic effects of a mutant of the heparin affin regulatory peptide on the U87 MG glioblastoma cell line.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Midkine and pleiotrophin have bactericidal properties: preserved antibacterial activity in a family of heparin-binding growth factors during evolution.
Title: Midkine and pleiotrophin have bactericidal properties: preserved antibacterial activity in a family of heparin-binding growth factors during evolution.
The data suggest that PTN expression in the human plaques may be in part regulated by IFN-gamma and that PTN is involved in the adaptive immunity.
Title: Pleiotrophin (PTN) is expressed in vascularized human atherosclerotic plaques: IFN-{gamma}/JAK/STAT1 signaling is critical for the expression of PTN in macrophages.

Submit: New GeneRIF Correction See all (61)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P21246	P60709	ACTB	HPRD	PubMed
P21246	Q9UM73	ALK	HPRD	PubMed
P21246	Phorbolin like protein MDS019	APOBEC3G	HPRD	PubMed
P21246	O95376	ARIH2	HPRD	PubMed
P21246	ADP ribosylation factor related protein 2	ARL15	HPRD	PubMed
P21246	P36542	ATP5C1	HPRD	PubMed
P21246	P46100	ATRX	HPRD	PubMed
P21246	Q99728	BARD1	HPRD	PubMed
P21246	Q9P287	BCCIP	HPRD	PubMed
P21246	P78537	BLOC1S1	HPRD	PubMed
P21246	P35226	BMI1	HPRD	PubMed
P21246	Q9BX70	BTBD2	HPRD	PubMed
P21246	Q9H8G2	CAAP1	HPRD	PubMed
P21246	O00305	CACNB4	HPRD	PubMed
P21246	P47756	CAPZB	HPRD	PubMed
P21246	Q9Y3C0	CCDC53	HPRD	PubMed
P21246	Q9Y6N8	CDH10	HPRD	PubMed
P21246	Q96SN8	CDK5RAP2	HPRD	PubMed
P21246	P01215	CGA	HPRD	PubMed
P21246	Q12873	CHD3	HPRD	PubMed
P21246	P09669	COX6C	HPRD	PubMed
P21246	Q9UGL9	CRCT1	HPRD	PubMed
P21246	Q96HD1	CRELD1	HPRD	PubMed
P21246	P01040	CSTA	HPRD	PubMed
P21246	O60443	DFNA5	HPRD	PubMed
P21246	Q9UBS4	DNAJB11	HPRD	PubMed
P21246	Q9UNI6	DUSP12	HPRD	PubMed
P21246	O00303	EIF3F	HPRD	PubMed
P21246	Q9H8M9	FAM176A	HPRD	PubMed
P21246	Q9BTY7	FAM203A	HPRD	PubMed
P21246	Q99689	FEZ1	HPRD	PubMed
P21246	P02792	FTL	HPRD	PubMed
P21246	O95257	GADD45G	HPRD	PubMed
P21246	Q8TF65	GIPC2	HPRD	PubMed
P21246	Glycine-N-acyltransferase	GLYAT	HPRD	PubMed
P21246	P63244	GNB2L1	HPRD	PubMed
P21246	P21695	GPD1	HPRD	PubMed
P21246	P09211	GSTP1	HPRD	PubMed
P21246	P35269	GTF2F1	HPRD	PubMed
P21246	Heat shock 27 kd protein associated protein 1	HSPBAP1	HPRD	PubMed
P21246	Q9NZM3	ITSN2	HPRD	PubMed
P21246	Q14974	KPNB1	HPRD	PubMed
P21246	Q16363	LAMA4	HPRD	PubMed
P21246	Q9Y383	LUC7L2	HPRD	PubMed
P21246	Q15013	MAD2L1BP	HPRD	PubMed
P21246	Q9NPJ1	MKKS	HPRD	PubMed
P21246	P42568	MLLT3	HPRD	PubMed
P21246	Q99417	MYCBP	HPRD	PubMed
P21246	Nucleosome assembly protein 1-like 5	NAP1L5	HPRD	PubMed
P21246	O14594	NCAN	HPRD	PubMed
P21246	P07237	P4HB	HPRD	PubMed
P21246	Q8N2W9	PIAS4	HPRD	PubMed
P21246	Plexin B2	PLXNB2	HPRD	PubMed
P21246	Q6P1K2	PMF1	HPRD	PubMed
P21246	Protein phosphatase 2A, catalytic subunit, alpha isoform	PPP2CA	HPRD	PubMed
P21246	P40306	PSMB10	HPRD	PubMed
P21246	O00231	PSMD11	HPRD	PubMed
P21246	Q13200	PSMD2	HPRD	PubMed
P21246	P21246	PTN	HPRD	PubMed
P21246	Q13332	PTPRS	HPRD	PubMed
P21246	P23471	PTPRZ1	HPRD	PubMed
P21246	Q86U06	RBM23	HPRD	PubMed
P21246	Q92963	RIT1	HPRD	PubMed
P21246	P05386	RPLP1	HPRD	PubMed
P21246	P21673	SAT1	HPRD	PubMed
P21246	P18827	SDC1	HPRD	PubMed
P21246	O75056	SDC3	HPRD	PubMed
P21246	RUN and TBC1 domain containing 1	SGSM2	HPRD	PubMed
P21246	O43765	SGTA	HPRD	PubMed
P21246	Q96CQ1	SLC25A36	HPRD	PubMed
P21246	Q9Y6H5	SNCAIP	HPRD	PubMed
P21246	Q9Y657	SPIN1	HPRD	PubMed
P21246	P43307	SSR1	HPRD	PubMed
P21246	O76061	STC2	HPRD	PubMed
P21246	O94864	SUPT7L	HPRD	PubMed
P21246	Q9UHF0	TAC3	HPRD	PubMed
P21246	Q9H5J8	TAF1D	HPRD	PubMed
P21246	Q969Z0	TBRG4	HPRD	PubMed
P21246	Q15388	TOMM20	HPRD	PubMed
P21246	Q13625	TP53BP2	HPRD	PubMed
P21246	O14530	TXNDC9	HPRD	PubMed
P21246	Q9NRR5	UBQLN4	HPRD	PubMed
P21246	Q9NQZ2	UTP3	HPRD	PubMed
P21246	Q14508	WFDC2	HPRD	PubMed
BioGRID:111731	BioGRID:106739	ALK	BioGRID	PubMed	Reconstituted Complex
BioGRID:111731	BioGRID:121920	APOBEC3G	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:115694	ARIH2	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:120080	ARL15	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:106997	ATP5C1	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:107028	ATRX	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:121161	BCCIP	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:107070	BCL2L1	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:108917	BLOC1S1	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:107116	BMI1	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:120778	BTBD2	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:116144	C11orf58	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:122489	C7orf25	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:122971	CAAP1	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:107239	CACNB4	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:107282	CAPZB	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:119225	CCDC53	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:107443	CDH10	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:120873	CDK5RAP2	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:107507	CGA	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:107532	CHD3	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:107738	COX6C	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:120031	CRCT1	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:122458	CRELD1	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:107880	CTNNB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111731	BioGRID:108049	DFNA5	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:119699	DNAJB11	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:116424	DUSP12	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:114214	EIF3F	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:123910	FAM176A	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:119398	FAM203A	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:108789	FTL	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:108014	GADD45A	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:120167	GIPC2	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:115543	GLYAT	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:115671	GNB2L1	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:109080	GPD1	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:109187	GSK3B	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:109205	GSTP1	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:109217	GTF2F1	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:122788	HSPBAP1	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:109314	HTT	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:119098	ITSN2	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:110104	LAMA4	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:119646	LUC7L2	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:114955	MAD2L1BP	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:113837	MKKS	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:110446	MLLT3	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:122389	MRPL44	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:117673	MYCBP	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:129344	NAP1L5	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:116237	NUDT21	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:111073	P4HB	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:111223	PFDN1	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:117178	PLXNB2	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:116405	PMF1	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:111507	PPP2CA	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:111672	PSMB10	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:111689	PSMD11	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:111681	PSMD2	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:111766	PTPRS	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:111767	PTPRZ1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111731	BioGRID:120450	RBM23	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:111948	RIT1	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:112095	RPLP1	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:112210	SAT1	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:112284	SDC1	BioGRID	PubMed	Reconstituted Complex
BioGRID:111731	BioGRID:115234	SGSM2	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:112347	SGTA	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:120484	SLC25A36	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:114986	SNCAIP	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:112623	SSR1	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:114172	STC2	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:115242	SUPT7L	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:112729	TAC3	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:122548	TAF1D	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:114666	TBRG4	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:115144	TOMM20	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:113012	TP53BP2	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:115487	TXNDC9	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:121223	UBQLN4	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:121342	UTP3	BioGRID	PubMed	Two-hybrid
BioGRID:111731	BioGRID:115677	WFDC2	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
growth factor activity	IEA Inferred from Electronic Annotation more info
heparin binding	IEA Inferred from Electronic Annotation more info
protein phosphatase inhibitor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
bone mineralization	IEA Inferred from Electronic Annotation more info
learning	IEA Inferred from Electronic Annotation more info
nervous system development	TAS Traceable Author Statement more info	PubMed
positive regulation of cell division	IEA Inferred from Electronic Annotation more info
positive regulation of cell proliferation	TAS Traceable Author Statement more info	PubMed
transmembrane receptor protein tyrosine phosphatase signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	TAS Traceable Author Statement more info	PubMed

General protein information

Preferred Names: pleiotrophin

Names: pleiotrophin; HBBM; OSF-1; HB-GAM; HBGF-8; HBNF-1; osteoblast-specific factor 1; heparin-binding brain mitogen; heparin binding growth factor 8; heparin-binding growth factor 8; heparin affin regulatory protein; neurite growth-promoting factor 1; heparin-binding growth-associated molecule; heparin-binding neurite outgrowth-promoting factor 1; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002825.5 → NP_002816.1 pleiotrophin precursor

Status: VALIDATED

Source sequence(s)

BC005916, BM968820, M57399

Consensus CDS

CCDS5844.1

UniProtKB/Swiss-Prot

P21246

Related

ENSP00000341170, OTTHUMP00000208521, ENST00000348225, OTTHUMT00000341339

Conserved Domains (1) summary

cl02505
Location:47 – 131
Blast Score: 310

PTN_MK_N; PTN/MK heparin-binding protein family, N-terminal domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000007.13 Reference GRCh37.p5 Primary Assembly

Range

136912088..137028546, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000139.1 Alternate HuRef

Range

131217379..131333760, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CRA_TCAGchr7v2

Genomic

AC_000068.1 Alternate CRA_TCAGchr7v2

Range

136256123..136372579, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC018728.6 (133761..177435)	None
genomic	AC078842.2	None
genomic	CH236950.1	EAL24052.1
genomic	CH471070.1	EAW83869.1
		EAW83870.1
		EAW83871.1
		EAW83872.1
genomic	S50409.1	AAB24425.1
genomic	S60110.1	AAB26456.1
genomic	S60111.1	AAB26456.1
mRNA	AK290488.1	BAF83177.1
mRNA	AK313424.1	BAG36216.1
mRNA	BC005916.1	AAH05916.1
mRNA	BM968820.1	None
mRNA	BT019692.1	AAV38498.1
mRNA	CR450338.1	CAG29334.1
mRNA	D90226.1	BAA14261.1
mRNA	M57399.1	AAA35961.1
mRNA	X52946.1	CAA37121.1
other-genetic	AM392897.1	CAL37775.1