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ARHGAP23 Rho GTPase activating protein 23 [ Homo sapiens (human) ]

Gene ID: 57636, updated on 8-May-2016
Official Symbol
ARHGAP23provided by HGNC
Official Full Name
Rho GTPase activating protein 23provided by HGNC
Primary source
HGNC:HGNC:29293
See related
Ensembl:ENSG00000275832 MIM:610590; Vega:OTTHUMG00000188547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008]
Orthologs
Location:
17q12
Exon count:
30
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (38419286..38512392)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36584720..36668628)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 179 Neighboring gene suppressor of cytokine signaling 7 Neighboring gene uncharacterized LOC101929494 Neighboring gene SRC kinase signaling inhibitor 1 Neighboring gene uncharacterized LOC105371761 Neighboring gene chromosome 17 open reading frame 96

NHGRI GWAS Catalog

Description
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
NHGRI GWA Catalog
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1501

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
GTPase activator activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
rho GTPase-activating protein 23
Names
rho-type GTPase-activating protein 23

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199417.1NP_001186346.1  rho GTPase-activating protein 23

    See identical proteins and their annotated locations for NP_001186346.1

    Status: VALIDATED

    Source sequence(s)
    AC244153, BM548592, BY795315, CN429246, CN429249, CN429251, DN831435, EG328307, R42869
    Consensus CDS
    CCDS56027.1
    UniProtKB/Swiss-Prot
    Q9P227
    Related
    ENSP00000481862, OTTHUMP00000276833, ENST00000622683, OTTHUMT00000477592
    Conserved Domains (3) summary
    cd00992
    Location:41151
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:9021097
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:690810
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    38419286..38512392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721991.1XP_006722054.1  

    See identical proteins and their annotated locations for XP_006722054.1

    Conserved Domains (3) summary
    cd00992
    Location:23133
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:8841079
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:672792
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  2. XM_006721992.2XP_006722055.1  

    See identical proteins and their annotated locations for XP_006722055.1

    Conserved Domains (3) summary
    cd00992
    Location:41151
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:8191014
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cl17171
    Location:590727
    PH-like; Pleckstrin homology-like domain
  3. XM_006721993.2XP_006722056.1  

    See identical proteins and their annotated locations for XP_006722056.1

    Conserved Domains (3) summary
    cd00992
    Location:41151
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:9021097
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:690810
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  4. XM_006721994.2XP_006722057.1  

    See identical proteins and their annotated locations for XP_006722057.1

    UniProtKB/Swiss-Prot
    Q9P227
    Related
    ENSP00000482992, OTTHUMP00000276834, ENST00000620417, OTTHUMT00000477593
    Conserved Domains (3) summary
    cd00992
    Location:41151
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:9021097
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:690810
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  5. XM_011525076.1XP_011523378.1  

    See identical proteins and their annotated locations for XP_011523378.1

    Conserved Domains (3) summary
    cd00992
    Location:41151
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:9021097
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:690810
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  6. XM_011525077.1XP_011523379.1  

    See identical proteins and their annotated locations for XP_011523379.1

    Conserved Domains (3) summary
    cd00992
    Location:41151
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:9021097
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:690810
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  7. XM_011525074.1XP_011523376.1  

    See identical proteins and their annotated locations for XP_011523376.1

    Conserved Domains (3) summary
    cd00992
    Location:457
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:8081003
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:596716
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  8. XM_011525073.1XP_011523375.1  

    See identical proteins and their annotated locations for XP_011523375.1

    Conserved Domains (3) summary
    cd00992
    Location:26136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:8871082
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:675795
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  9. XM_011525075.1XP_011523377.1  

    See identical proteins and their annotated locations for XP_011523377.1

    Conserved Domains (2) summary
    cd04395
    Location:696891
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:484604
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

RNA

  1. XR_429909.2 RNA Sequence

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    2454595..2547694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006725330.1XP_006725393.1  

    See identical proteins and their annotated locations for XP_006725393.1

    Conserved Domains (3) summary
    cd00992
    Location:23133
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:8841079
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:672792
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  2. XM_006725331.2XP_006725394.1  

    See identical proteins and their annotated locations for XP_006725394.1

    Conserved Domains (3) summary
    cd00992
    Location:41151
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:8191014
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cl17171
    Location:590727
    PH-like; Pleckstrin homology-like domain
  3. XM_006725332.2XP_006725395.1  

    See identical proteins and their annotated locations for XP_006725395.1

    Conserved Domains (3) summary
    cd00992
    Location:41151
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:9021097
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:690810
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  4. XM_006725333.2XP_006725396.1  

    See identical proteins and their annotated locations for XP_006725396.1

    UniProtKB/Swiss-Prot
    Q9P227
    Conserved Domains (3) summary
    cd00992
    Location:41151
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:9021097
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:690810
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  5. XM_011546817.1XP_011545119.1  

    See identical proteins and their annotated locations for XP_011545119.1

    Conserved Domains (3) summary
    cd00992
    Location:41151
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:9021097
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:690810
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  6. XM_011546818.1XP_011545120.1  

    See identical proteins and their annotated locations for XP_011545120.1

    Conserved Domains (3) summary
    cd00992
    Location:41151
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:9021097
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:690810
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  7. XM_011546815.1XP_011545117.1  

    See identical proteins and their annotated locations for XP_011545117.1

    Conserved Domains (3) summary
    cd00992
    Location:457
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:8081003
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:596716
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  8. XM_011546814.1XP_011545116.1  

    See identical proteins and their annotated locations for XP_011545116.1

    Conserved Domains (3) summary
    cd00992
    Location:26136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:8871082
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:675795
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  9. XM_011546816.1XP_011545118.1  

    See identical proteins and their annotated locations for XP_011545118.1

    Conserved Domains (2) summary
    cd04395
    Location:696891
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:484604
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

RNA

  1. XR_430785.2 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    36820039..36903955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020876.1: Suppressed sequence

    Description
    NM_020876.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate, and the CDS is partial on the 5' end.