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    EP400 E1A binding protein p400 [ Homo sapiens ]

    Gene ID: 57634, updated on 11-May-2012
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    Summary

    Official Symbol
    EP400provided by HGNC
    Official Full Name
    E1A binding protein p400provided by HGNC
    Primary source
    HGNC:11958
    See related
    Ensembl:ENSG00000183495; HPRD:09378; MIM:606265; Vega:OTTHUMG00000150175
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P400; CAGH32; TNRC12; FLJ42018; FLJ45115; DKFZP434I225
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    Genomic context

    Location :
    12q24.33
    Sequence :
    Chromosome: 12; NC_000012.11 (132434465..132565011)
    See EP400 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene unc-51-like kinase 1 (C. elegans) Neighboring gene pseudouridylate synthase 1 Neighboring gene small nucleolar RNA, H/ACA box 49 Neighboring gene EP400 N-terminal like Neighboring gene uncharacterized LOC100288611

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest. Reitsma JM, et al. Cell Host Microbe, 2011 Feb 17. PMID 21320693.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Kim J, et al. Cell, 2010 Oct 15. PMID 20946988.

    See all (37) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. p400 is a novel DNA damage response protein and p400-mediated alterations in nucleosome and chromatin structure promote both chromatin ubiquitination and the accumulation of brca1 and 53BP1 at sites of DNA damage.
      Title: The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair.
    2. Depletion of p400 indeed increases intracellular reactive oxygen species levels and causes the appearance of DNA damage
      Title: The E1A-associated p400 protein modulates cell fate decisions by the regulation of ROS homeostasis.
    3. Results suggest that p400 represses basal p21 gene expression through dual mechanisms that include direct inhibition of TIP60 and ATP-dependent positioning of H2A.Z at the promoter.
      Title: The SANT domain of p400 ATPase represses acetyltransferase activity and coactivator function of TIP60 in basal p21 gene expression.
    4. p400/Tip60 ratio is critical for colon cancer cells proliferation and response to therapeutic drugs through the control of stress-response pathways.
      Title: The p400/Tip60 ratio is critical for colorectal cancer cell proliferation through DNA damage response pathways.
    5. Myc recruits the Tip60/p400 complex to achieve a coordinated histone acetylation/exchange reaction at activated promoters.
      Title: Analysis of Myc-induced histone modifications on target chromatin.
    6. These findings establish that Myc, via p400, is an essential downstream target of adenovirus E1A.
      Title: Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc.
    7. p400 is a component of the p53-p21(WAF1/CIP1/sid1) pathway, regulating the p21 transcription and cell senescence induction program.
      Title: The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway.
    8. p400 is a regulator of the ARF-p53 pathway and a component of the cellular machinery that couples proliferation to cell death
      Title: p400 is required for E1A to promote apoptosis.
    9. Tip60 and p400 play distinct roles in DNA damage-induced apoptosis and underline the importance of the Tip60 complex and its regulation in the proper control of cell fate.
      Title: Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q96L91 O60343 TBC1D4    HPRD  PubMed  
    Q96L91 Q9Y4A5 TRRAP    HPRD  PubMed  
    BioGRID:121676 BioGRID:106601 ACTL6A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121676 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121676 BioGRID:121004 DMAP1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:121676 BioGRID:115779 KAT5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation 
    BioGRID:121676 BioGRID:110319 MAX    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:121676 BioGRID:116134 MORF4L1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121676 BioGRID:115001 MORF4L2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121676 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:121676 BioGRID:114166 RUVBL1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:121676 BioGRID:116067 RUVBL2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:121676 BioGRID:115213 TBC1D4    BioGRID  PubMed Two-hybrid 
    BioGRID:121676 BioGRID:113900 TRRAP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:121676 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121676 BioGRID:1678002 UL27    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121676 BioGRID:115989 ZMYND11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:121676 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    histone H2A acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    histone H4 acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    E1A-binding protein p400
    Names
    E1A-binding protein p400
    hDomino
    domino homolog
    CAG repeat protein 32
    p400 SWI2/SNF2-related protein
    p400 kDa SWI2/SNF2-related protein
    trinucleotide repeat containing 12
    trinucleotide repeat-containing gene 12 protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015409.4 → NP_056224.3  E1A-binding protein p400

      Status: VALIDATED

      Source sequence(s)
      AB058721, AC137590, AC137632, AY044869, DA450209
      Consensus CDS
      CCDS31929.2
      UniProtKB/Swiss-Prot
      Q96L91
      Related
      ENSP00000374212, ENST00000389561
      Conserved Domains (5) summary
      cd00046
      Location:1075 – 1210
      Blast Score: 136
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:1855 – 1983
      Blast Score: 166
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:1058 – 1338
      Blast Score: 582
      SNF2_N; SNF2 family N-terminal domain
      cl02676
      Location:764 – 835
      Blast Score: 250
      HSA; HSA
      cl15779
      Location:2330 – 2391
      Blast Score: 93
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      132434465..132565011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      129320249..129451108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC131009.7 (167612..170326) None
    genomic AC137590.2 (15523..126724) None
    genomic AC137632.7 (2004..15573) None
    genomic CH471054.1 EAW98534.1
      EAW98535.1
      EAW98536.1
    mRNA AB040931.1 BAA96022.1
    mRNA AB058721.1 BAB47447.1
    mRNA AK025040.1 None
    mRNA AK074395.1 None
    mRNA AK096311.1 BAC04759.1
    mRNA AK097299.1 None
    mRNA AK124012.1 None
    mRNA AK127058.1 None
    mRNA AL832718.1 None
    mRNA AW376113.1 None
    mRNA AY044869.1 AAK97789.1
    mRNA BC016068.1 None
    mRNA BC037208.1 AAH37208.1
    mRNA BC064554.1 AAH64554.1
    mRNA BC150291.1 AAI50292.1
    mRNA BX369075.2 None
    mRNA DA450209.1 None
    mRNA U80743.1 AAB91441.1
    other-genetic JF432826.1 ADZ16043.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96L91.4 GenPept UniProtKB/Swiss-Prot:Q96L91
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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