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    TAOK1 TAO kinase 1 [ Homo sapiens ]

    Gene ID: 57551, updated on 11-May-2012
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    Summary

    Official Symbol
    TAOK1provided by HGNC
    Official Full Name
    TAO kinase 1provided by HGNC
    Primary source
    HGNC:29259
    See related
    Ensembl:ENSG00000160551; HPRD:15467; MIM:610266
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSK2; TAO1; KFC-B; MARKK; PSK-2; hKFC-B; hTAOK1; MAP3K16; FLJ14314; KIAA1361
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    Genomic context

    Location :
    17q11.2
    Sequence :
    Chromosome: 17; NC_000017.10 (27717943..27878921)
    See TAOK1 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35a pseudogene 35 Neighboring gene microRNA 4523 Neighboring gene abhydrolase domain containing 15 Neighboring gene tumor protein p53 inducible protein 13

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway. Poon CL, et al. Dev Cell, 2011 Nov 15. PMID 22075148.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. Network organization of the human autophagy system. Behrends C, et al. Nature, 2010 Jul 1. PMID 20562859.

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Human TAO1 can phosphorylate and activate human MST2
      Title: The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway.
    2. Data do not support the notion that Tao1 is a component of the spindle checkpoint.
      Title: Re-evaluating the role of Tao1 in the spindle checkpoint.
    3. the apparent role of the Tao1 kinase in spindle checkpoing signaling might in reality reflect an off-target effect produced by particular Tao1-directed siRNA oligonucleotides on Mad2
      Title: Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs.
    4. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: A genome-wide association study identifies three loci associated with mean platelet volume.
    5. Spred1-MARKK binding has no effect on the activity of MARKK; therefore, it does not change microtubule (MT) stability.
      Title: Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton.
    6. It is concluded that human TAO kinase 1 induces apoptosis in SH-SY5Y cells and the kinase domain is essential, but its catalytic activity seems to be dispensable in this case.
      Title: Human TAO kinase 1 induces apoptosis in SH-SY5Y cells.
    7. TAO kinases are regulators of p38-mediated responses to DNA damage and are intermediates in the activation of p38 by ATM.
      Title: TAO kinases mediate activation of p38 in response to DNA damage.
    8. Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1
      Title: Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1.
    9. Dual functions of TAO1 in regulating microtubule dynamics and checkpoint signalling may help to coordinate the establishment and monitoring of correct congression of chromosomes, thereby protecting genomic stability in human cells.
      Title: A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    A genome-wide association study identifies three loci associated with mean platelet volume.

    A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q7L7X3 P46734 MAP2K3    HPRD  PubMed  
    Q7L7X3 Q9P0L2 MARK1    HPRD  PubMed  
    BioGRID:121607 BioGRID:122420 C8orf33    BioGRID  PubMed Two-hybrid 
    BioGRID:121607 BioGRID:107838 CSNK1E    BioGRID  PubMed Two-hybrid 
    BioGRID:121607 BioGRID:108118 DYNC1I1    BioGRID  PubMed Two-hybrid 
    BioGRID:121607 BioGRID:122869 GEMIN7    BioGRID  PubMed Two-hybrid 
    BioGRID:121607 BioGRID:112665 STK4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121607 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121607 BioGRID:113327 WT1    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • DNA Replication, organism-specific biosystem (from REACTOME)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • M Phase, organism-specific biosystem (from REACTOME)
      M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Mitotic M-M/G1 phases, organism-specific biosystem (from REACTOME)
      Mitotic M-M/G1 phases, organism-specific biosystem
      Mitotic M-M/G1 phases
    • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
      Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and ...
    • p38 MAPK signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      p38 MAPK signaling pathway, organism-specific biosystem
      p38 MAPK signaling pathway

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    transferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    G2/M transition DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    M phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    mitotic prometaphase TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of stress-activated MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT spindle checkpoint IDA
    Inferred from Direct Assay
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    serine/threonine-protein kinase TAO1
    Names
    serine/threonine-protein kinase TAO1
    MARK Kinase
    STE20-like kinase PSK2
    kinase from chicken homolog B
    prostate-derived STE20-like kinase 2
    thousand and one amino acid protein 1
    prostate-derived sterile 20-like kinase 2
    serine/threonine protein kinase TAO1 homolog
    thousand and one amino acid protein kinase 1
    microtubule affinity regulating kinase kinase
    NP_065842.1
    NP_079418.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020791.2 → NP_065842.1  serine/threonine-protein kinase TAO1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC068025, AC090698, BC133039, CK300429
      Consensus CDS
      CCDS32601.1
      UniProtKB/Swiss-Prot
      Q7L7X3
      Related
      ENSP00000261716, ENST00000261716
      Conserved Domains (3) summary
      COG0419
      Location:452 – 873
      Blast Score: 109
      SbcC; ATPase involved in DNA repair [DNA replication, recombination, and repair]
      cd06607
      Location:12 – 318
      Blast Score: 1722
      STKc_TAO; Catalytic domain of the Protein Serine/Threonine Kinase, Thousand-and-one amino acids proteins
      smart00220
      Location:28 – 281
      Blast Score: 700
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    2. NM_025142.1 → NP_079418.1  serine/threonine-protein kinase TAO1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC068025, AC090698, BC144067, CK300429
      Consensus CDS
      CCDS56024.1
      Related
      ENSP00000438819, ENST00000536202
      Conserved Domains (3) summary
      cd06607
      Location:12 – 318
      Blast Score: 1729
      STKc_TAO; Catalytic domain of the Protein Serine/Threonine Kinase, Thousand-and-one amino acids proteins
      TIGR02169
      Location:449 – 729
      Blast Score: 122
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      smart00220
      Location:28 – 281
      Blast Score: 704
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      27717943..27878921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      23926953..24088276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC068025.12 (145319..190193) None
    genomic AC068588.20 None
    genomic AC090698.14 (15749..86261) None
    genomic CH471159.1 EAW51188.1
      EAW51189.1
      EAW51190.1
    genomic CQ834802.1 CAH05616.1
    mRNA AB037782.1 BAA92599.1
    mRNA AF263312.1 AAG38502.1
    mRNA AK024376.1 BAB14901.1
    mRNA AK025902.1 None
    mRNA AL110163.1 None
    mRNA AY049015.1 AAL12217.1
    mRNA BC024166.1 None
    mRNA BC032793.1 None
    mRNA BC037535.2 None
    mRNA BC037740.2 None
    mRNA BC047652.1 None
    mRNA BC051737.1 None
    mRNA BC062764.1 None
    mRNA BC133039.1 AAI33040.1
    mRNA BC144067.1 AAI44068.1
    mRNA BE772351.1 None
    mRNA CA395289.1 None
    mRNA CK300429.1 None
    mRNA AL833649.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7L7X3.1 GenPept UniProtKB/Swiss-Prot:Q7L7X3
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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