PTK7 PTK7 protein tyrosine kinase 7 [Homo sapiens] - Gene

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Summary

Official Symbol: PTK7provided by HGNC
Official Full Name: PTK7 protein tyrosine kinase 7provided by HGNC
Primary source: HGNC:9618
See related: Ensembl:ENSG00000112655; HPRD:03534; MIM:601890; Vega:OTTHUMG00000014721
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CCK4
Summary: Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene is a member of this subgroup of tyrosine kinases and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 6p21.1-p12.2

Sequence :: Chromosome: 6; NC_000006.11 (43044029..43129457)

See PTK7 in Epigenomics, MapViewer

Chromosome 6 - NC_000006.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

aberrations in the membrane type 1 matrix metalloproteinase/PTK7 axis are detrimental to cell movements that shape the body plan
Title: Potential relation of aberrant proteolysis of human protein tyrosine kinase 7 (PTK7) chuzhoi by membrane type 1 matrix metalloproteinase (MT1-MMP) to congenital defects.
Observations may indicate a role for PTK7 in cell proliferation and cell apoptosis and may provide a potential therapeutic pathway for the treatment of a variety of cancers.
Title: Silencing of PTK7 in colon cancer cells: caspase-10-dependent apoptosis via mitochondrial pathway.
Protein Tyrosine Kinase 7 is required for beta-catenin-dependent transcriptional events induced by canonical Wnt ligands
Title: Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling.
Results indicate that PTK7 is a major target of MT1-MMP.
Title: The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis.
PTK7 is a planar cell polarity component expressed in the myeloid progenitor compartment that conveys promigratory and antiapoptotic signals into the cell and represents an independent prognosis factor in patients treated with induction chemotherapy.
Title: The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome.
PTK7 plays an important role not only in tube formation, migration, and invasion of endothelial cells but also in angiogenesis.
Title: Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis.
mechanism of PTK7 upregulation in colorectal cancer
Title: Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells.
Lack of a thermodynamically meaningful self-association propensity for the CCK4 transmembrane domains demonstrates that the conserved GxxxG motif is not sufficient to drive CCK4 transmembrane helix-helix interactions.
Title: The GxxxG-containing transmembrane domain of the CCK4 oncogene does not encode preferential self-interactions.
cloning, sequencing and expression of gene and its splice variants
Title: Organization of the human PTK7 gene encoding a receptor protein tyrosine kinase-like molecule and alternative splicing of its mRNA.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q13308	Q13308	PTK7	HPRD	PubMed
BioGRID:111721	BioGRID:112171	RYK	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111721	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
receptor activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info
transmembrane receptor protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
actin cytoskeleton reorganization	IMP Inferred from Mutant Phenotype more info
axis elongation	IEA Inferred from Electronic Annotation more info
canonical Wnt receptor signaling pathway	IMP Inferred from Mutant Phenotype more info
cell adhesion	IEA Inferred from Electronic Annotation more info
cell migration	IMP Inferred from Mutant Phenotype more info
cellular response to retinoic acid	IMP Inferred from Mutant Phenotype more info	PubMed
cochlea morphogenesis	IEA Inferred from Electronic Annotation more info
convergent extension	IEA Inferred from Electronic Annotation more info
establishment of epithelial cell apical/basal polarity	IEA Inferred from Electronic Annotation more info
establishment of planar polarity	IEA Inferred from Electronic Annotation more info
lung-associated mesenchyme development	IEA Inferred from Electronic Annotation more info
neural tube closure	IEA Inferred from Electronic Annotation more info
planar cell polarity pathway involved in neural tube closure	IEA Inferred from Electronic Annotation more info
positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
signal transduction	TAS Traceable Author Statement more info	PubMed
wound healing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell-cell junction	IDA Inferred from Direct Assay more info
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
membrane	IEA Inferred from Electronic Annotation more info
membrane fraction	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: inactive tyrosine-protein kinase 7

Names: inactive tyrosine-protein kinase 7; CCK-4; colon carcinoma kinase 4; colon carcinoma kinase-4; protein-tyrosine kinase 7; tyrosine-protein kinase-like 7; pseudo tyrosine kinase receptor 7

NP_002812.2

EC 2.7.10.1

NP_690619.1

EC 2.7.10.1

NP_690620.1

EC 2.7.10.1

NP_690621.1

EC 2.7.10.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002821.3 → NP_002812.2 inactive tyrosine-protein kinase 7 isoform a precursor

Status: REVIEWED

Description

Transcript Variant: This variant (PTK7-1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AF531868, BC002377, BM811107

Consensus CDS

CCDS4884.1

UniProtKB/Swiss-Prot

Q13308

Related

ENSP00000230419, OTTHUMP00000016421, ENST00000230419, OTTHUMT00000040580

Conserved Domains (6) summary

cd05046
Location:790 – 1063
Blast Score: 1343

PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4

cd00096
Location:609 – 669
Blast Score: 141

Ig; Immunoglobulin domain

cd05760
Location:146 – 222
Blast Score: 430

Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4

pfam07679
Location:503 – 588
Blast Score: 166

I-set; Immunoglobulin I-set domain

smart00221
Location:801 – 1061
Blast Score: 920

STYKc; Protein kinase; unclassified specificity.

cl11960
Location:414 – 498
Blast Score: 135

Ig; Immunoglobulin domain
NM_152880.2 → NP_690619.1 inactive tyrosine-protein kinase 7 isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (PTK7-2) lacks an alternate in-frame exon compared to variant PTK7-1, resulting in a shorter isoform (b) compared to isoform a.

Source sequence(s)

AF531869, BC002377, BM811107

Consensus CDS

CCDS4885.1

UniProtKB/Swiss-Prot

Q13308

Related

ENSP00000325992, OTTHUMP00000217014, ENST00000345201, OTTHUMT00000358217

Conserved Domains (6) summary

cd05046
Location:750 – 1023
Blast Score: 1345

PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4

cd00096
Location:242 – 302
Blast Score: 122

Ig; Immunoglobulin domain

cd05760
Location:146 – 222
Blast Score: 430

Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4

pfam07679
Location:412 – 498
Blast Score: 165

I-set; Immunoglobulin I-set domain

smart00221
Location:761 – 1021
Blast Score: 920

STYKc; Protein kinase; unclassified specificity.

cl11960
Location:571 – 629
Blast Score: 142

Ig; Immunoglobulin domain
NM_152881.2 → NP_690620.1 inactive tyrosine-protein kinase 7 isoform c precursor

Status: REVIEWED

Description

Transcript Variant: This variant (PTK7-3) lacks an alternate in-frame segment compared to variant PTK7-1, resulting in a shorter isoform (c) compared to isoform a.

Source sequence(s)

AF531870, BC002377, BM811107

Consensus CDS

CCDS4886.1

UniProtKB/Swiss-Prot

Q13308

Related

ENSP00000325462, OTTHUMP00000217005, ENST00000349241, OTTHUMT00000358200

Conserved Domains (6) summary

cd05046
Location:660 – 933
Blast Score: 1347

PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4

cd00096
Location:479 – 539
Blast Score: 142

Ig; Immunoglobulin domain

cd05760
Location:146 – 222
Blast Score: 429

Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4

pfam07679
Location:128 – 219
Blast Score: 156

I-set; Immunoglobulin I-set domain

smart00221
Location:671 – 931
Blast Score: 921

STYKc; Protein kinase; unclassified specificity.

cl11960
Location:329 – 401
Blast Score: 128

Ig; Immunoglobulin domain
NM_152882.2 → NP_690621.1 inactive tyrosine-protein kinase 7 isoform d precursor

Status: REVIEWED

Description

Transcript Variant: This variant (PTK7-4) lacks an alternate in-frame segment compared to variant PTK7-1, resulting in a shorter isoform (d) compared to isoform a.

Source sequence(s)

AF531871, BC002377, BM811107

Consensus CDS

CCDS4887.1

UniProtKB/Swiss-Prot

Q13308

Related

ENSP00000326029, OTTHUMP00000217013, ENST00000352931, OTTHUMT00000358216

Conserved Domains (6) summary

cd05046
Location:734 – 1007
Blast Score: 1340

PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4

cd00096
Location:520 – 585
Blast Score: 136

Ig; Immunoglobulin domain

cd05760
Location:146 – 222
Blast Score: 431

Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4

pfam07679
Location:503 – 588
Blast Score: 166

I-set; Immunoglobulin I-set domain

smart00221
Location:745 – 1005
Blast Score: 921

STYKc; Protein kinase; unclassified specificity.

cl11960
Location:414 – 498
Blast Score: 135

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000006.11 Reference GRCh37.p5 Primary Assembly

Range

43044029..43129457

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000138.1 Alternate HuRef

Range

42761022..42846113

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_152883.1: Suppressed sequence

Description

NM_152883.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF447157.1	AAL39062.1
genomic	AF447158.1	AAL39062.1
genomic	AF447162.1	AAL39062.1
genomic	AF447164.1	AAL39062.1
genomic	AF447167.1	AAL39062.1
genomic	AF447170.1	AAL39062.1
genomic	AF447171.1	AAL39062.1
genomic	AF447173.1	AAL39062.1
genomic	AF447174.1	AAL39062.1
genomic	AF447175.1	AAL39062.1
genomic	AF447176.1	AAL39062.1
genomic	AL355385.15	CAI13783.1
genomic	CH471081.1	EAX04154.1
		EAX04155.1
		EAX04156.1
		EAX04157.1
		EAX04158.1
		EAX04159.1
		EAX04160.1
mRNA	AB209350.1	BAD92587.1
mRNA	AF531868.1	AAN04862.1
mRNA	AF531869.1	AAN04863.1
mRNA	AF531870.1	AAN04864.1
mRNA	AF531871.1	AAN04865.1
mRNA	AF531872.1	AAN04866.1
mRNA	AK055648.1	BAG51548.1
mRNA	AK093428.1	None
mRNA	AK097717.1	None
mRNA	AK131487.1	None
mRNA	AK291016.1	BAF83705.1
mRNA	AK292589.1	BAF85278.1
mRNA	AK296931.1	BAH12457.1
mRNA	AK296953.1	BAH12463.1
mRNA	AL157486.1	CAB75674.1
mRNA	BC002377.2	None
mRNA	BC014626.2	None
mRNA	BC046109.2	AAH46109.1
mRNA	BC071557.1	AAH71557.1
mRNA	BM811107.1	None
mRNA	U33635.1	AAA87565.1
mRNA	U40271.2	AAC50484.2

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q13308.2	GenPept	UniProtKB/Swiss-Prot:Q13308
Q59FV9	GenPept	UniProtKB/TrEMBL:Q59FV9
Q86X91	GenPept	UniProtKB/TrEMBL:Q86X91
Q9NSQ6	GenPept	UniProtKB/TrEMBL:Q9NSQ6