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    MIB1 mindbomb E3 ubiquitin protein ligase 1 [ Homo sapiens ]

    Gene ID: 57534, updated on 11-May-2012

    Summary

    Official Symbol
    MIB1provided by HGNC
    Official Full Name
    mindbomb E3 ubiquitin protein ligase 1provided by HGNC
    Primary source
    HGNC:21086
    See related
    Ensembl:ENSG00000101752; HPRD:06660; MIM:608677; Vega:OTTHUMG00000131753
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIB; ZZZ6; DIP-1; ZZANK2; FLJ90676; MGC129659; MGC129660; DKFZp686I0769; DKFZp761M1710

    Genomic context

    Location :
    18q11.2
    Sequence :
    Chromosome: 18; NC_000018.9 (19321545..19450914)
    See MIB1 in Epigenomics, MapViewer

    Chromosome 18 - NC_000018.9Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein D1 polypeptide 16kDa Neighboring gene abhydrolase domain containing 3 Neighboring gene microRNA 320c-1 Neighboring gene microRNA 133a-1 Neighboring gene microRNA 1-2 Neighboring gene ribosomal protein L34 pseudogene 32 Neighboring gene RNA, U7 small nuclear 17 pseudogene Neighboring gene uncharacterized LOC100128893

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q86YT6 P98082 DAB2    HPRD  PubMed  
    Q86YT6 P53355 DAPK1    HPRD  PubMed  
    Q86YT6 Q9Y5X3 SNX5    HPRD  PubMed  
    BioGRID:121593 BioGRID:122142 AZI2    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:121593 BioGRID:198290 Azi1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121593 BioGRID:107982 DAPK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:121593 BioGRID:118391 DLL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:121593 BioGRID:106689 JAG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:121593 BioGRID:111139 PCM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121593 BioGRID:112171 RYK    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:121593 BioGRID:118878 TBK1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:121593 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:121593 BioGRID:113169 UBE2D1    BioGRID  PubMed Two-hybrid 
    BioGRID:121593 BioGRID:113170 UBE2D2    BioGRID  PubMed Two-hybrid 
    BioGRID:121593 BioGRID:113171 UBE2D3    BioGRID  PubMed Two-hybrid 
    BioGRID:121593 BioGRID:119641 UBE2D4    BioGRID  PubMed Two-hybrid 
    BioGRID:121593 BioGRID:113182 UBE2N    BioGRID  PubMed Two-hybrid 
    BioGRID:121593 BioGRID:127156 UBE2U    BioGRID  PubMed Two-hybrid 
    BioGRID:121593 BioGRID:120572 UBE2W    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem (from REACTOME)
      Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystemMature NOTCH1 heterodimer on the cell surface is activated by one of its ligands: DLL1 (Cordle et al. 2008, Jarriault et al. 1998), DLL4 (Benedito et al. 2009), JAG1 (Li et al. 1998, Benedito et al. ...
    • Notch signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Notch signaling pathway, organism-specific biosystem
      Notch signaling pathway
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
    • Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1, organism-specific biosystemNOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.NOTCH1 receptor presented on the plasma membrane is activated by a me...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    blood vessel development IEA
    Inferred from Electronic Annotation
    more info
     
    heart development IEA
    Inferred from Electronic Annotation
    more info
     
    heart looping IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    neural tube formation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase MIB1
    Names
    E3 ubiquitin-protein ligase MIB1
    mindbomb homolog 1
    mind bomb homolog 1
    DAPK-interacting protein 1
    ubiquitin ligase mind bomb
    ubiquitin ligase protein MIB1
    zinc finger ZZ type with ankyrin repeat domain protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020774.2NP_065825.1  E3 ubiquitin-protein ligase MIB1

      Status: VALIDATED

      Source sequence(s)
      AC103987, AY149908
      Consensus CDS
      CCDS11871.1
      UniProtKB/Swiss-Prot
      Q86YT6
      Related
      ENSP00000261537, OTTHUMP00000162549, ENST00000261537, OTTHUMT00000254675
      Conserved Domains (8) summary
      cd00204
      Location:524652
      Blast Score: 306
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd02339
      Location:83127
      Blast Score: 224
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      pfam06701
      Location:1574
      Blast Score: 254
      MIB_HERC2; Mib_herc2
      PHA03095
      Location:668778
      Blast Score: 100
      PHA03095; ankyrin-like protein; Provisional
      pfam12796
      Location:600696
      Blast Score: 214
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:450504
      Blast Score: 98
      Ank_5; Ankyrin repeats (many copies)
      pfam13923
      Location:959997
      Blast Score: 111
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
      cl15348
      Location:864907
      Blast Score: 144
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000018.9 Reference GRCh37.p5 Primary Assembly

      Range
      19321545..19450914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000150.1 Alternate HuRef

      Range
      16168791..16298313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC091038.9 None
    genomic AC103987.5 (44489..98225) None
    genomic CH471088.1 EAX01132.1
    genomic EF444995.1 ACA06016.1
    mRNA AB037744.1 BAA92561.1
    mRNA AF086463.1 None
    mRNA AK027338.1 None
    mRNA AK075157.1 BAC11439.1
    mRNA AK091266.1 BAG52320.1
    mRNA AL713705.1 CAD28502.1
    mRNA AY147849.1 AAN18023.1
    mRNA AY149908.1 AAN75493.1
    mRNA BC022403.1 AAH22403.1
    mRNA BC110581.1 AAI10582.1
    mRNA BC110582.1 AAI10583.1
    mRNA CR749635.1 CAH18429.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86YT6.1 GenPept UniProtKB/Swiss-Prot:Q86YT6

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