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PTK6 protein tyrosine kinase 6 [ Homo sapiens (human) ]

Gene ID: 5753, updated on 26-May-2016
Official Symbol
PTK6provided by HGNC
Official Full Name
protein tyrosine kinase 6provided by HGNC
Primary source
HGNC:HGNC:9617
See related
Ensembl:ENSG00000101213 HPRD:03594; MIM:602004; Vega:OTTHUMG00000033039
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRK
Summary
The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Orthologs
Location:
20q13.3
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 20 NC_000020.11 (63528413..63537370, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62159766..62168723, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723814 Neighboring gene pancreatic progenitor cell differentiation and proliferation factor Neighboring gene src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites Neighboring gene chromosome 20 open reading frame 195

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem (from REACTOME)
    Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystemCyclin A:Cdk2 plays a key role in S phase entry by phosphorylation of proteins including Cdh1, Rb, p21 and p27. During G1 phase of the cell cycle, cyclin A is synthesized and associates with Cdk2. Af...
  • Cyclin E associated events during G1/S transition, organism-specific biosystem (from REACTOME)
    Cyclin E associated events during G1/S transition, organism-specific biosystemThe transition from the G1 to S phase is controlled by the Cyclin E:Cdk2 complexes. As the Cyclin E:Cdk2 complexes are formed, the Cdk2 is phosphorylated by the Wee1 and Myt1 kinases. This phosphoryl...
  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • ERBB2 Activates PTK6 Signaling, organism-specific biosystem (from REACTOME)
    ERBB2 Activates PTK6 Signaling, organism-specific biosystemPTK6 (BRK) is activated downstream of ERBB2 (HER) (Xiang et al. 2008, Peng et al. 2015) and other receptor tyrosine kinases, such as EGFR (Kamalati et al. 1996) and MET (Castro and Lange 2010). Howev...
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • G1/S Transition, organism-specific biosystem (from REACTOME)
    G1/S Transition, organism-specific biosystemCyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include p...
  • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
    Mitotic G1-G1/S phases, organism-specific biosystem
    Mitotic G1-G1/S phases
  • PTK6 Activates STAT3, organism-specific biosystem (from REACTOME)
    PTK6 Activates STAT3, organism-specific biosystemPTK6-mediated phosphorylation activates STAT3 transcription factor via STAP2 adapter protein. STAT3 transcriptional target SOCS3 is a negative regulator of PTK6 and inhibits PTK6-mediated phosphoryla...
  • PTK6 Down-Regulation, organism-specific biosystem (from REACTOME)
    PTK6 Down-Regulation, organism-specific biosystemThe kinase activity of PTK6 is negatively regulated by both PTPN1 phosphatase (Fan et al. 2013), which dephosphorylates tyrosine Y342 of PTK6, and SRMS kinase (Fan et al. 2015), which phosphorylates ...
  • PTK6 Expression, organism-specific biosystem (from REACTOME)
    PTK6 Expression, organism-specific biosystemLevels of PTK6 increase under hypoxic conditions due to direct transcriptional regulation of PTK6 gene by hypoxia inducible transcription factors (HIFs) (Regan Anderson et al. 2013). PTK6 protein lev...
  • PTK6 Regulates Cell Cycle, organism-specific biosystem (from REACTOME)
    PTK6 Regulates Cell Cycle, organism-specific biosystemPTK6 promotes cell cycle progression by phosphorylating and inactivating CDK inhibitor CDKN1B (p27) (Patel et al. 2015). PTK6 also negatively modulates CDKN1B expression via regulation of the activit...
  • PTK6 Regulates Proteins Involved in RNA Processing, organism-specific biosystem (from REACTOME)
    PTK6 Regulates Proteins Involved in RNA Processing, organism-specific biosystemPTK6 binds and phosphorylates several nuclear RNA-binding proteins, including SAM68 family members (KHDRSB1, KHDRSB2 and KHDRSB3) (Derry et al. 2000, Haegebarth et al. 2004, Lukong et al. 2005) and S...
  • PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases, organism-specific biosystem (from REACTOME)
    PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases, organism-specific biosystemPTK6 promotes cell motility and migration by regulating the activity of RHO GTPases RAC1 (Chen et al. 2004) and RHOA (Shen et al. 2008). PTK6 inhibits RAS GTPase activating protein RASA1 (Shen et al....
  • PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1, organism-specific biosystem (from REACTOME)
    PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1, organism-specific biosystemPTK6 enhances EGFR signaling by inhibiting EGFR down-regulation (Kang et al. 2010, Li et al. 2012, Kang and Lee 2013). PTK6 may also enhance signaling by other receptor tyrosine kinases (RTKs), such ...
  • PTK6 promotes HIF1A stabilization, organism-specific biosystem (from REACTOME)
    PTK6 promotes HIF1A stabilization, organism-specific biosystemHBEGF-stimulated formation of EGFR heterodimers with GPNMB triggers PTK6-mediated phosphorylation and stabilization of the hypoxia inducible factor 1 alpha (HIF1A) under normoxic conditions. This pro...
  • S Phase, organism-specific biosystem (from REACTOME)
    S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continues,...
  • SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystem (from REACTOME)
    SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystemDuring G1, the activity of cyclin-dependent kinases (CDKs) is kept in check by the CDK inhibitors (CKIs) p27 and p21, thereby preventing premature entry into S phase (see Guardavaccaro and Pagano, 20...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
    Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
  • Signaling by PTK6, organism-specific biosystem (from REACTOME)
    Signaling by PTK6, organism-specific biosystemPTK6 (BRK) is an oncogenic non-receptor tyrosine kinase that functions downstream of ERBB2 (HER2) (Xiang et al. 2008, Peng et al. 2015) and other receptor tyrosine kinases, such as EGFR (Kamalati et ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ42088

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
ERBB2 signaling pathway TAS
Traceable Author Statement
more info
 
cell migration IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to retinoic acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
intestinal epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of signal transduction TAS
Traceable Author Statement
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of cell cycle TAS
Traceable Author Statement
more info
 
positive regulation of epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tyrosine phosphorylation of Stat3 protein TAS
Traceable Author Statement
more info
 
protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
tyrosine phosphorylation of Stat3 protein IDA
Inferred from Direct Assay
more info
PubMed 
tyrosine phosphorylation of Stat5 protein IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
protein-tyrosine kinase 6
Names
PTK6 protein tyrosine kinase 6
breast tumor kinase
protein-tyrosine kinase BRK
tyrosine-protein kinase BRK
NP_001243287.1
NP_005966.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256358.1NP_001243287.1  protein-tyrosine kinase 6 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region which results in a frameshift and early stop codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1. This variant is also known as lambdaM5 and Alt-PTK6.
    Source sequence(s)
    AK301364, AL121829, X78549
    Consensus CDS
    CCDS74750.1
    UniProtKB/Swiss-Prot
    Q13882
    Related
    ENSP00000217185, ENST00000217185
    Conserved Domains (1) summary
    cd11847
    Location:1269
    SH3_Brk; Src homology 3 domain of Brk (Breast tumor kinase) Protein Tyrosine Kinase (PTK), also called PTK6
  2. NM_005975.3NP_005966.1  protein-tyrosine kinase 6 isoform 1

    See identical proteins and their annotated locations for NP_005966.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AL121829, BC035843, DA762278, X78549
    Consensus CDS
    CCDS13524.1
    UniProtKB/Swiss-Prot
    Q13882
    Related
    ENSP00000442460, OTTHUMP00000031656, ENST00000542869, OTTHUMT00000080313
    Conserved Domains (4) summary
    cd05148
    Location:184444
    PTKc_Srm_Brk; Catalytic domain of the Protein Tyrosine Kinases, Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites (Srm) and Breast tumor kinase (Brk)
    cd10358
    Location:75174
    SH2_PTK6_Brk; Src homology 2 domain found in protein-tyrosine kinase-6 (PTK6) which is also known as breast tumor kinase (Brk)
    cd11847
    Location:1269
    SH3_Brk; Src homology 3 domain of Brk (Breast tumor kinase) Protein Tyrosine Kinase (PTK), also called PTK6
    smart00221
    Location:192441
    STYKc; Protein kinase; unclassified specificity

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p2 Primary Assembly

    Range
    63528413..63537370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_936592.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    62060892..62069731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)