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HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 [ Homo sapiens (human) ]

Gene ID: 57520, updated on 26-May-2016
Official Symbol
HECW2provided by HGNC
Official Full Name
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2provided by HGNC
Primary source
HGNC:HGNC:29853
See related
Ensembl:ENSG00000138411 HPRD:17099; Vega:OTTHUMG00000154435
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEDL2
Orthologs
Location:
2q32.3
Exon count:
31
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (196199000..196593692, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (197063971..197458416, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373820 Neighboring gene uncharacterized LOC101927454 Neighboring gene serine/threonine kinase 17b Neighboring gene uncharacterized LOC101927482 Neighboring gene uncharacterized LOC105373822 Neighboring gene uncharacterized LOC105373821 Neighboring gene uncharacterized LOC105373823 Neighboring gene coiled-coil domain containing 150 Neighboring gene uncharacterized LOC100130452

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp686M17164

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
E3 ubiquitin-protein ligase HECW2
Names
HECT, C2 and WW domain-containing protein 2
NEDD4-like E3 ubiquitin-protein ligase 2
NEDD4-related E3 ubiquitin ligase NEDL2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304840.1NP_001291769.1  E3 ubiquitin-protein ligase HECW2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon in place of the first two exons, uses an alternate splice junction at the 5' end of an exon, and lacks an alternate exon compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AB037722, AC020571, AL390186, CR749424
    Consensus CDS
    CCDS77499.1
    UniProtKB/Swiss-Prot
    Q9P2P5
    Related
    ENSP00000386775, OTTHUMP00000205738, ENST00000409111, OTTHUMT00000335314
    Conserved Domains (5) summary
    pfam06390
    Location:108275
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00119
    Location:8841213
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:8601214
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:454483
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam15479
    Location:318441
    DUF4639; Domain of unknown function (DUF4639)
  2. NM_020760.2NP_065811.1  E3 ubiquitin-protein ligase HECW2 isoform 1

    See identical proteins and their annotated locations for NP_065811.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB037722, AC020571, AL390186, BC117194
    Consensus CDS
    CCDS33354.1
    UniProtKB/Swiss-Prot
    Q9P2P5
    Related
    ENSP00000260983, OTTHUMP00000205668, ENST00000260983, OTTHUMT00000335199
    Conserved Domains (6) summary
    pfam06390
    Location:464631
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    cd08691
    Location:185321
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00119
    Location:12401569
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:12161570
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:810839
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam15479
    Location:674797
    DUF4639; Domain of unknown function (DUF4639)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    196199000..196593692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712646.2XP_006712709.1  

    Conserved Domains (7) summary
    pfam06390
    Location:471638
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    cd08691
    Location:185321
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00119
    Location:12471576
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:12231577
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:817846
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam02063
    Location:567818
    MARCKS; MARCKS family
    pfam15479
    Location:681804
    DUF4639; Domain of unknown function (DUF4639)
  2. XM_006712648.2XP_006712711.1  

    Conserved Domains (6) summary
    pfam06390
    Location:340507
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    cd08691
    Location:54190
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00119
    Location:11161445
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:10921446
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:686715
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam15479
    Location:550673
    DUF4639; Domain of unknown function (DUF4639)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    197069842..197463246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)