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    XPO5 exportin 5 [ Homo sapiens (human) ]

    Gene ID: 57510, updated on 5-May-2013
    Official Symbol
    XPO5provided by HGNC
    Official Full Name
    exportin 5provided by HGNC
    Primary source
    HGNC:17675
    Locus tag
    RP3-337H4.5
    See related
    Ensembl:ENSG00000124571; HPRD:06385; MIM:607845; Vega:OTTHUMG00000014742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    exp5
    Summary
    This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]
    Location :
    6p21.1
    Sequence :
    Chromosome: 6; NC_000006.11 (43490068..43543812, complement)
    See XPO5 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene Yip1 domain family, member 3 Neighboring gene polymerase (RNA) I polypeptide C, 30kDa Neighboring gene ribosomal protein S2 pseudogene 29 Neighboring gene polymerase (DNA directed), eta Neighboring gene GTP binding protein 2 Neighboring gene MAD2L1 binding protein

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells. Buanne P, et al. J Proteome Res, 2013 Jan 4. PMID 23181366.
    2. NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. Yatim A, et al. Mol Cell, 2012 Nov 9. PMID 23022380.
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965.
    4. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629.
    5. A high-throughput approach for measuring temporal changes in the interactome. Kristensen AR, et al. Nat Methods, 2012 Sep. PMID 22863883.

    See all (54) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Dicer, Drosha, and Exportin 5 genes were up-regulated in bladder urothelial carcinoma compared to normal urothelium. Silencing these genes induced cell proliferation inhibition and apoptosis in bladder urothelial carcinoma cells.
      Title: Inducing cell proliferation inhibition and apoptosis via silencing Dicer, Drosha, and Exportin 5 in urothelial carcinoma of the bladder.
    2. overall survival was significantly longer in multiple myeloma patients with C/C or A/C variant in the XPO5 gene single nucleotide polymorphism site rs11077
      Title: Impact of MiRSNPs on survival and progression in patients with multiple myeloma undergoing autologous stem cell transplantation.
    3. Exportin-5 controls Dicer1 expression post-transcriptionally.
      Title: Competition for XPO5 binding between Dicer mRNA, pre-miRNA and viral RNA regulates human Dicer levels.
    4. Data show a requirement for the export receptor Exportin 5 in nuclear export of 60S subunits in human cells, and that Exp5 binds to pre-60S particles in a RanGTP-dependent manner.
      Title: A protein inventory of human ribosome biogenesis reveals an essential function of exportin 5 in 60S subunit export.
    5. The restoration of XPO5 functions reverses the impaired export of pre-miRNAs and has tumor-suppressor features.
      Title: A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells.
    6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan.
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    8. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes.
    9. 2.9 angstrom structure of the pre-miRNA nuclear export machinery formed by pre-miRNA complexed with Exp-5 and RanGTP; RNA recognition by Exp-5:RanGTP does not depend on RNA sequence, implying that Exp-5:RanGTP can recognize a variety of pre-miRNAs
      Title: A high-resolution structure of the pre-microRNA nuclear export machinery.
    10. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
    Submit: New GeneRIF Correction See all (17)

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    Vpu, p16 vpu HIV-1 Vpu is identified to have a physical interaction with exportin 5 (XPO5) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NP_065801.1     BIND  PubMed Exp5 interacts with pre-miR-31, a precursor of microRNA 31. 
    Q9HAV4 P68104 EEF1A1    HPRD  PubMed  
    Q9HAV4 Q13158 FADD    HPRD  PubMed  
    Q9HAV4 Q12906 ILF3    HPRD  PubMed  
    Q9HAV4 P49790 NUP153    HPRD  PubMed  
    Q9HAV4 P35658 NUP214    HPRD  PubMed  
    Q9HAV4 P62826 RAN    HPRD  PubMed  
    Q9HAV4 Q13485 SMAD4    HPRD  PubMed  
    Q9HAV4 Q9UL40 ZNF346    HPRD  PubMed  
    BioGRID:121574 BioGRID:123290 AARSD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:117348 ARIH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:107049 BAG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:107223 CA9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:121258 DUS3L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:199230 Dlg4    BioGRID  PubMed Protein-peptide 
    BioGRID:121574 BioGRID:108237 EEF1A1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:121574 BioGRID:114749 EFTUD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:121937 ELAC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:108621 FN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:131875 GSTK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:109215 GTF2E1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:109285 HARS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:109822 ILF3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:121574 BioGRID:109883 ITGA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:122098 LEPRE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:110279 MAGEA6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:118166 MAT2B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:122103 MMS19    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:119337 MRTO4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:121574 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:116000 NEK6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:110913 NOTCH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:110954 NRD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:120236 NSUN2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:115297 NUP153    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:121574 BioGRID:113717 NUP214    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:121574 BioGRID:115434 PDIA6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:111226 PFDN5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:117145 PHLDA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:110742 PPP1R12A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:111522 PPP3CA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:116327 PTP4A3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:111837 RAN    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:121574 BioGRID:112208 SARS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:116155 SERINC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:111288 SERPINE2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:112366 SHMT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:119602 SIRT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:110264 SMAD4    BioGRID  PubMed Two-hybrid 
    BioGRID:121574 BioGRID:118022 SNX5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:113116 TTC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:119509 UCHL5    BioGRID  PubMed Co-fractionation 
    BioGRID:121574 BioGRID:113205 UGDH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:113255 VCAM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:116001 WDR4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121574 BioGRID:117109 ZNF346    BioGRID  PubMed Reconstituted Complex 
    BioGRID:121574 BioGRID:1205543 vpu    BioGRID  PubMed Affinity Capture-MS 
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • MicroRNA (miRNA) Biogenesis, organism-specific biosystem (from REACTOME)
      MicroRNA (miRNA) Biogenesis, organism-specific biosystemBiogenesis of microRNAs (miRNAs) can be summarized in five steps (reviewed in Ketting 2011, Nowotny and Yang 2009, Kim et al. 2009, Chua et al. 2009, Hannon and He 2004):1. Transcription. miRNA trans...
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • Regulatory RNA pathways, organism-specific biosystem (from REACTOME)
      Regulatory RNA pathways, organism-specific biosystemIn this module, the biology of various types of regulatory non-coding RNAs are described. Currently, biogenesis and functions of small interfering RNAs (siRNAs) and microRNAs are annotated.

    Markers

    Genotypes

    Homology

    Clone Names

    • FLJ14239, FLJ32057, FLJ45606, KIAA1291

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding TAS
    Traceable Author Statement
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    Preferred Names
    exportin-5
    Names
    exportin-5
    ran-binding protein 21

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020750.2 → NP_065801.1  exportin-5

      Status: VALIDATED

      Source sequence(s)
      AB033117, AF298880, BF108994, DB068849
      Consensus CDS
      CCDS47430.1
      UniProtKB/Swiss-Prot
      Q9HAV4
      Related
      ENSP00000265351, OTTHUMP00000016472, ENST00000265351, OTTHUMT00000040657
      Conserved Domains (2) summary
      smart00913
      Location:33 – 100
      Blast Score: 127
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:109 – 243
      Blast Score: 274
      Xpo1; Exportin 1-like protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p10 Primary Assembly

      Range
      43490068..43543812, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      43209042..43263034, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018917.1 Alternate CHM1_1.0

      Range
      43400824..43454569, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01050673.1 (9840..20519) None
    genomic ABBA01050674.1 None
    genomic ABBA01050675.1 None
    genomic ABBA01050676.1 None
    genomic ABBA01050677.1 None
    genomic ABBA01050678.1 (2956..6840) None
    genomic AL355802.13 (35087..88831) None
    genomic AMYH01016314.1 (66691..120436) None
    genomic CH471081.1 EAX04206.1
      EAX04207.1
    mRNA AB033117.2 BAA86605.2
    mRNA AF271159.1 AAG53603.1
    mRNA AF298880.1 AAG17907.1
    mRNA AK001195.1 BAA91547.1
    mRNA AK022718.1 BAB14200.1
    mRNA AK023431.1 BAB14572.1
    mRNA AK024301.1 BAG51288.1
    mRNA AK025864.1 None
    mRNA AK056619.1 BAG51767.1
    mRNA AK127513.1 None
    mRNA AK291452.1 BAF84141.1
    mRNA AL137467.1 CAB70753.1
    mRNA AL834207.1 None
    mRNA BC000129.1 AAH00129.1
    mRNA BC008347.1 AAH08347.1
    mRNA BC009969.2 AAH09969.2
    mRNA BC062635.1 AAH62635.1
    mRNA BF108994.1 None
    mRNA DB068849.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HAV4.1 GenPept UniProtKB/Swiss-Prot:Q9HAV4

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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