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XPO5 exportin 5 [ Homo sapiens (human) ]

Gene ID: 57510, updated on 8-May-2016
Official Symbol
XPO5provided by HGNC
Official Full Name
exportin 5provided by HGNC
Primary source
HGNC:HGNC:17675
See related
Ensembl:ENSG00000124571 HPRD:06385; MIM:607845; Vega:OTTHUMG00000014742
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
exp5
Summary
This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]
Orthologs
Location:
6p21.1
Exon count:
32
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (43522330..43576075, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43490068..43543812, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 73 Neighboring gene Yip1 domain family member 3 Neighboring gene polymerase (RNA) I subunit C Neighboring gene ribosomal protein S2 pseudogene 29 Neighboring gene polymerase (DNA) eta Neighboring gene GTP binding protein 2 Neighboring gene MAD2L1 binding protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with exportin 5 (XPO5) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Gene Silencing by RNA, organism-specific biosystem (from REACTOME)
    Gene Silencing by RNA, organism-specific biosystemIn this module, the biology of various types of regulatory non-coding RNAs are described. Currently, biogenesis and functions of small interfering RNAs (siRNAs) and microRNAs are annotated.
  • MicroRNA (miRNA) biogenesis, organism-specific biosystem (from REACTOME)
    MicroRNA (miRNA) biogenesis, organism-specific biosystemBiogenesis of microRNAs (miRNAs) can be summarized in five steps (reviewed in Ketting 2011, Nowotny and Yang 2009, Kim et al. 2009, Chua et al. 2009, Hannon and He 2004):1. Transcription. miRNA trans...
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ14239, FLJ32057, FLJ45606, KIAA1291

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding TAS
Traceable Author Statement
more info
 
Ran GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
Ran GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
pre-miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to pre-miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
pre-miRNA transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein transporter activity IEA
Inferred from Electronic Annotation
more info
 
tRNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
gene silencing by RNA TAS
Traceable Author Statement
more info
 
positive regulation of RNA interference IDA
Inferred from Direct Assay
more info
PubMed 
pre-miRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
pre-miRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
RNA nuclear export complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
exportin-5
Names
ran-binding protein 21

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020750.2NP_065801.1  exportin-5

    See identical proteins and their annotated locations for NP_065801.1

    Status: VALIDATED

    Source sequence(s)
    AB033117, AF298880, BF108994, DB068849
    Consensus CDS
    CCDS47430.1
    UniProtKB/Swiss-Prot
    Q9HAV4
    Related
    ENSP00000265351, OTTHUMP00000016472, ENST00000265351, OTTHUMT00000040657
    Conserved Domains (2) summary
    smart00913
    Location:33100
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:109248
    Xpo1; Exportin 1-like protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    43522330..43576075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    43493200..43546895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)