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INTS2 integrator complex subunit 2 [ Homo sapiens (human) ]

Gene ID: 57508, updated on 8-May-2016
Official Symbol
INTS2provided by HGNC
Official Full Name
integrator complex subunit 2provided by HGNC
Primary source
HGNC:HGNC:29241
See related
Ensembl:ENSG00000108506 HPRD:11137; MIM:611346; Vega:OTTHUMG00000179234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INT2; KIAA1287
Summary
INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Orthologs
Location:
17q23.2
Exon count:
27
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (61865367..61928030, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (59942728..60005377, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene nascent polypeptide associated complex alpha subunit 2 Neighboring gene BRCA1 interacting protein C-terminal helicase 1 Neighboring gene uncharacterized LOC105371851 Neighboring gene mediator complex subunit 13 Neighboring gene uncharacterized LOC105371852

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • RNA polymerase II transcribes snRNA genes, organism-specific biosystem (from REACTOME)
    RNA polymerase II transcribes snRNA genes, organism-specific biosystemSmall nuclear RNAs (snRNAs) play key roles in splicing and some of them, specifically the U1 and U2 snRNAs, are encoded by multicopy snRNA gene clusters containing tandem arrays of genes, about 30 in...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
snRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
snRNA transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integrator complex IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IDA
Inferred from Direct Assay
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
Preferred Names
integrator complex subunit 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020748.2NP_065799.1  integrator complex subunit 2

    See identical proteins and their annotated locations for NP_065799.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the protein-coding variant.
    Source sequence(s)
    AC060798, AL136800
    Consensus CDS
    CCDS45750.1
    UniProtKB/Swiss-Prot
    Q9H0H0
    Related
    ENSP00000414237, OTTHUMP00000260966, ENST00000444766, OTTHUMT00000445368
    Conserved Domains (1) summary
    pfam14750
    Location:311138
    INTS2; Integrator complex subunit 2

RNA

  1. NR_026641.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction downstream of the translation start site used in variant 1, resulting in a severely truncated protein product. Therefore, it is likely that variant 2 does not encode a protein.
    Source sequence(s)
    AB033113, AC060798, AL136800

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    61865367..61928030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257537.2XP_005257594.1  

    Conserved Domains (1) summary
    pfam14750
    Location:311100
    INTS2; Integrator complex subunit 2
  2. XM_006721987.2XP_006722050.1  

    See identical proteins and their annotated locations for XP_006722050.1

    UniProtKB/TrEMBL
    J3KMZ7
    Related
    ENSP00000251334, OTTHUMP00000260967, ENST00000251334, OTTHUMT00000445369
    Conserved Domains (1) summary
    pfam14750
    Location:231130
    INTS2; Integrator complex subunit 2
  3. XM_011525058.1XP_011523360.1  

    See identical proteins and their annotated locations for XP_011523360.1

    UniProtKB/TrEMBL
    J3KMZ7
    Conserved Domains (1) summary
    pfam14750
    Location:231130
    INTS2; Integrator complex subunit 2

RNA

  1. XR_934509.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    60007281..60069924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)