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ADGRB1 adhesion G protein-coupled receptor B1 [ Homo sapiens (human) ]

Gene ID: 575, updated on 26-May-2016
Official Symbol
ADGRB1provided by HGNC
Official Full Name
adhesion G protein-coupled receptor B1provided by HGNC
Primary source
HGNC:HGNC:943
See related
Ensembl:ENSG00000181790 HPRD:04062; MIM:602682; Vega:OTTHUMG00000164732
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAI1; GDAIF
Summary
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]
Orthologs
Location:
8q24.3
Exon count:
31
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (142449888..142545008)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143545377..143626369)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 51 Neighboring gene t-SNARE domain containing 1 Neighboring gene maestro heat like repeat family member 4, pseudogene Neighboring gene activity-regulated cytoskeleton-associated protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat LRRK2 kinase inhibition suppresses HIV-1 Tat-induced upregulation of phosphatidylserine receptor BAI1 in microglia cells PubMed

Go to the HIV-1, Human Interaction Database

  • p53 signaling pathway, organism-specific biosystem (from KEGG)
    p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53 signaling pathway, conserved biosystem (from KEGG)
    p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ41988

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
axonogenesis TAS
Traceable Author Statement
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
peripheral nervous system development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell-cell junction TAS
Traceable Author Statement
more info
PubMed 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
brain-specific angiogenesis inhibitor 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001702.2NP_001693.2  brain-specific angiogenesis inhibitor 1 precursor

    See identical proteins and their annotated locations for NP_001693.2

    Status: REVIEWED

    Source sequence(s)
    AB005297, AC139676
    Consensus CDS
    CCDS64985.1
    UniProtKB/Swiss-Prot
    O14514
    Related
    ENSP00000313046, ENST00000323289
    Conserved Domains (5) summary
    smart00303
    Location:880938
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:577643
    HormR; Domain present in hormone receptors
    smart00209
    Location:412462
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9441180
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam12003
    Location:653875
    DUF3497; Domain of unknown function (DUF3497)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    142449888..142545008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517202.1XP_011515504.1  

    Related
    ENSP00000427783, OTTHUMP00000227746, ENST00000521208, OTTHUMT00000380655
    Conserved Domains (5) summary
    smart00303
    Location:880938
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:577643
    HormR; Domain present in hormone receptors
    smart00209
    Location:412462
    TSP1; Thrombospondin type 1 repeats
    pfam12003
    Location:653875
    DUF3497; Domain of unknown function (DUF3497)
    cl21587
    Location:9441140
    7tm_2; 7 transmembrane receptor (Secretin family)
  2. XM_011517199.1XP_011515501.1  

    See identical proteins and their annotated locations for XP_011515501.1

    UniProtKB/Swiss-Prot
    O14514
    Related
    ENSP00000430945, OTTHUMP00000227339, ENST00000517894, OTTHUMT00000379963
    Conserved Domains (5) summary
    smart00303
    Location:880938
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:577643
    HormR; Domain present in hormone receptors
    smart00209
    Location:412462
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9441180
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam12003
    Location:653875
    DUF3497; Domain of unknown function (DUF3497)
  3. XM_011517200.1XP_011515502.1  

    Conserved Domains (5) summary
    smart00303
    Location:877935
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:574640
    HormR; Domain present in hormone receptors
    smart00209
    Location:412462
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9411177
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam12003
    Location:650872
    DUF3497; Domain of unknown function (DUF3497)
  4. XM_011517201.1XP_011515503.1  

    Conserved Domains (5) summary
    smart00303
    Location:825883
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:522588
    HormR; Domain present in hormone receptors
    smart00209
    Location:357407
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:8891125
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam12003
    Location:598820
    DUF3497; Domain of unknown function (DUF3497)

RNA

  1. XR_928342.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    143585613..143666276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)