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PTK2 protein tyrosine kinase 2 [ Homo sapiens (human) ]

Gene ID: 5747, updated on 14-Apr-2014
Official Symbol
PTK2provided by HGNC
Official Full Name
protein tyrosine kinase 2provided by HGNC
Primary source
HGNC:9611
See related
Ensembl:ENSG00000169398; HPRD:02859; MIM:600758; Vega:OTTHUMG00000067438
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAK; FADK; FAK1; FRNK; PPP1R71; p125FAK; pp125FAK
Summary
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010]
Location :
8q24.3
Sequence :
Chromosome: 8; NC_000008.11 (140658382..141001313, complement)
See PTK2 in Epigenomics, MapViewer

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene chromatin accessibility complex 1 Neighboring gene argonaute RISC catalytic component 2 Neighboring gene microRNA 151a Neighboring gene RNA, 5S ribosomal pseudogene 278 Neighboring gene uncharacterized LOC101927963 Neighboring gene DENN/MADD domain containing 3 Neighboring gene solute carrier family 45, member 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-β therapy in multiple sclerosis patients.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-stimulated cells overexpressing NHERF1 upregulates FAK phosphorylation PubMed
env Focal adhesion kinase (FAK), CD4, and HIV-1 gp120 co-localize in T cells. The formation of FAK-CD4 complex is induced by gp120 PubMed
Tat, p14 tat Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin (3) subunit, pp60src and recruits VEGFR2, integrin (3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes PubMed
tat Focal adhesion kinase (FAK) is tyrosine-phosphorylated by Tat, and inhibition of FAK by the dominant interfering mutant form, FAK-related nonkinase, significantly blocks HBMEC migration and disrupted focal adhesions upon Tat activation PubMed
tat HIV-1 Tat upregulates p125FAK and induces the tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 neuronal cells PubMed
tat HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3, which triggers the activation of focal adhesion kinase, RhoA and pp60src PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem"Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligand...
  • Amoebiasis, organism-specific biosystem (from KEGG)
    Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Amoebiasis, conserved biosystem (from KEGG)
    Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
  • Angiogenesis, organism-specific biosystem (from WikiPathways)
    Angiogenesis, organism-specific biosystemThis pathway is a concise and simplified version of the basic proteins involved in angiogenesis. The proces is regulated by hyopoxia, which results in the transcription of eg. VEGF1, FGF2, PDGFbeta, ...
  • Apoptosis, organism-specific biosystem (from REACTOME)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
    Apoptotic cleavage of cellular proteins, organism-specific biosystemApoptotic cell death is achieved by the caspase-mediatedcleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adduc...
  • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
    Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
  • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
    Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
  • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
    Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
  • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    CXCR4-mediated signaling events, organism-specific biosystem
    CXCR4-mediated signaling events
  • Cell-Cell communication, organism-specific biosystem (from REACTOME)
    Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
  • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, conserved biosystem (from KEGG)
    Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Corticotropin-releasing hormone, organism-specific biosystem (from WikiPathways)
    Corticotropin-releasing hormone, organism-specific biosystemCorticotropin-releasing hormone (CRH) is a neuropeptide secreted abundantly in the paraventricular nucleus of the hypothalamus, amygdala, cerebral cortex and cerebellum in the central nervous system ...
  • DCC mediated attractive signaling, organism-specific biosystem (from REACTOME)
    DCC mediated attractive signaling, organism-specific biosystemThe DCC family includes DCC and neogenin in vertebrates. DCC is required for netrin-induced axon attraction. DCC is a transmembrane protein lacking any identifiable catalytic activity. Protein tyrosi...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
    ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
  • ErbB signaling pathway, organism-specific biosystem (from KEGG)
    ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
  • ErbB signaling pathway, conserved biosystem (from KEGG)
    ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
  • Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
    Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemPhagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phag...
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • GRB2:SOS provides linkage to MAPK signaling for Intergrins, organism-specific biosystem (from REACTOME)
    GRB2:SOS provides linkage to MAPK signaling for Intergrins, organism-specific biosystemIntegrin signaling is linked to the MAP kinase pathway by recruiting Grb2 to the FADK1/SRC activation complex.
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
  • IL-4 signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-4 signaling Pathway, organism-specific biosystemInterleukin-4 belongs to the IL-2 family of cytokines, which includes IL-2, IL-7, IL-9, IL-15 and IL-21. It signals through 2 different receptor complexes; Receptor complex 1 comprises of IL-4 recept...
  • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Integrin alphaIIb beta3 signaling, organism-specific biosystem (from REACTOME)
    Integrin alphaIIb beta3 signaling, organism-specific biosystemAt the sites of vascular injury bioactive molecules such as thrombin, ADP, collagen, fibrinogen and thrombospondin are generated, secreted or exposed. These stimuli activate platelets, converting the...
  • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
    Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
  • LPA receptor mediated events, organism-specific biosystem (from Pathway Interaction Database)
    LPA receptor mediated events, organism-specific biosystem
    LPA receptor mediated events
  • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
    Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
    Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • NCAM signaling for neurite out-growth, organism-specific biosystem (from REACTOME)
    NCAM signaling for neurite out-growth, organism-specific biosystemThe neural cell adhesion molecule, NCAM, is a member of the immunoglobulin (Ig) superfamily and is involved in a variety of cellular processes of importance for the formation and maintenance of the n...
  • Netrin mediated repulsion signals, organism-specific biosystem (from REACTOME)
    Netrin mediated repulsion signals, organism-specific biosystemUnc5 netrin receptors mediate repellent responses to netrin. Four Unc5 members have been found in humans: Unc5A, B, C and D. Different studies have suggested that long-range repulsion to netrin requi...
  • Netrin-1 signaling, organism-specific biosystem (from REACTOME)
    Netrin-1 signaling, organism-specific biosystemNetrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse a...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Platelet Aggregation (Plug Formation), organism-specific biosystem (from REACTOME)
    Platelet Aggregation (Plug Formation), organism-specific biosystemThe tethering of platelets to the site of vascular injury is the first step in the formation of a platelet thrombus. Firm adhesion of these tethered platelets, as well as the additional recruitment o...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
  • Prolactin Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Prolactin Signaling Pathway, organism-specific biosystemProlactin (PRL), a pleiotropic polypeptide hormone, mostly secreted by the lactotrophic cells of anterior pituitary gland and to a lesser extent expressed in numerous extra pituitary tissues such as ...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • RANKL/RANK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    RANKL/RANK Signaling Pathway, organism-specific biosystemRANKL (Receptor activator of nuclear factor-kappa B ligand), RANK (Receptor activator of nuclear factor-kappa B) and the natural decoy receptor of RANKL, OPG (Osteoprotegerin) are three important mol...
  • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
    Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystem (from REACTOME)
    Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystemThe actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signal regulatory protein (SIRP) family interactions, organism-specific biosystem (from REACTOME)
    Signal regulatory protein (SIRP) family interactions, organism-specific biosystemSignal regulatory protein (SIRP)alpha, also known as SHPS-1 or SIRPA or CD172a, is a transmembrane protein expressed mostly on myeloid cells. CD47, a widely expressed transmembrane protein, is a liga...
  • Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem (from WikiPathways)
    Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem
    Signaling of Hepatocyte Growth Factor Receptor
  • Small cell lung cancer, organism-specific biosystem (from KEGG)
    Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • Small cell lung cancer, conserved biosystem (from KEGG)
    Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
  • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
    Transcriptional misregulation in cancer, organism-specific biosystem
    Transcriptional misregulation in cancer
  • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
    Transcriptional misregulation in cancer, conserved biosystem
    Transcriptional misregulation in cancer
  • VEGF signaling pathway, organism-specific biosystem (from KEGG)
    VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
  • VEGF signaling pathway, conserved biosystem (from KEGG)
    VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
  • p130Cas linkage to MAPK signaling for integrins, organism-specific biosystem (from REACTOME)
    p130Cas linkage to MAPK signaling for integrins, organism-specific biosystemIntegrin signaling is linked to the MAP kinase pathway by recruiting p130cas and Crk to the FAK/Src activation complex.
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
JUN kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
SH2 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
angiogenesis TAS
Traceable Author Statement
more info
 
apoptotic process TAS
Traceable Author Statement
more info
 
axon guidance TAS
Traceable Author Statement
more info
PubMed 
blood coagulation TAS
Traceable Author Statement
more info
 
cell motility TAS
Traceable Author Statement
more info
PubMed 
cellular component disassembly involved in execution phase of apoptosis TAS
Traceable Author Statement
more info
 
central nervous system neuron axonogenesis IEA
Inferred from Electronic Annotation
more info
 
embryo development TAS
Traceable Author Statement
more info
 
endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
establishment of cell polarity TAS
Traceable Author Statement
more info
PubMed 
establishment of nucleus localization IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
growth hormone receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
heart morphogenesis TAS
Traceable Author Statement
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell-cell adhesion IDA
Inferred from Direct Assay
more info
 
negative regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
netrin-activated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
placenta development TAS
Traceable Author Statement
more info
 
platelet activation TAS
Traceable Author Statement
more info
 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phosphatidylinositol 3-kinase activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of Rho GTPase activity TAS
Traceable Author Statement
more info
PubMed 
regulation of cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
regulation of endothelial cell migration TAS
Traceable Author Statement
more info
 
regulation of focal adhesion assembly TAS
Traceable Author Statement
more info
PubMed 
regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal complex assembly IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
focal adhesion kinase 1
Names
focal adhesion kinase 1
FADK 1
PTK2 protein tyrosine kinase 2
FAK-related non-kinase polypeptide
focal adhesion kinase-related nonkinase
protein phosphatase 1 regulatory subunit 71
protein phosphatase 1, regulatory subunit 71
NP_001186578.1
NP_005598.3
NP_722560.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029467.1 RefSeqGene

    Range
    5001..347932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199649.1NP_001186578.1  focal adhesion kinase 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence, and contains two additional in-frame segments near the 3' end of the coding sequence, compared to variant 2. The resulting isoform (c) is shorter at the N-terminus and contains two additional segments in the C-terminus compared to isoform b.
    Source sequence(s)
    AB209083, AK304356, AL832961, BF434494, DA236314, DA994616, DB478006
    Consensus CDS
    CCDS56557.1
    UniProtKB/Swiss-Prot
    Q05397
    UniProtKB/TrEMBL
    Q59GM6
    UniProtKB/TrEMBL
    Q658W2
    Related
    ENSP00000341189, OTTHUMP00000226350, ENST00000340930, OTTHUMT00000378103
    Conserved Domains (6) summary
    cd05056
    Location:415684
    Blast Score: 1512
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:9271065
    Blast Score: 673
    Focal_AT; Focal adhesion targeting region
    smart00295
    Location:36258
    Blast Score: 369
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    Blast Score: 521
    FERM_C_FAK1; Focal Adhesion Kinase 1 and 2 FERM domain C-lobe
    pfam00373
    Location:143248
    Blast Score: 141
    FERM_M; FERM central domain
    pfam07714
    Location:422676
    Blast Score: 1034
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_005607.4NP_005598.3  focal adhesion kinase 1 isoform b

    See proteins identical to NP_005598.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (b).
    Source sequence(s)
    AB209083, AC100860, AL832961, BF434494, DA236314, DB478006
    UniProtKB/TrEMBL
    Q59GM6
    UniProtKB/TrEMBL
    Q658W2
    Conserved Domains (6) summary
    cd05056
    Location:437706
    Blast Score: 1512
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:9361074
    Blast Score: 671
    Focal_AT; Focal adhesion targeting region
    smart00295
    Location:58280
    Blast Score: 368
    B41; Band 4.1 homologues
    cd13190
    Location:276386
    Blast Score: 519
    FERM_C_FAK1; Focal Adhesion Kinase 1 and 2 FERM domain C-lobe
    pfam00373
    Location:165270
    Blast Score: 141
    FERM_M; FERM central domain
    pfam07714
    Location:444698
    Blast Score: 1033
    Pkinase_Tyr; Protein tyrosine kinase
  3. NM_153831.3NP_722560.1  focal adhesion kinase 1 isoform a

    See proteins identical to NP_722560.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (a) is shorter at the N-terminus compared to isoform b.
    Source sequence(s)
    AB209083, AL832961, BF434494, DA236314, DB478006, L13616
    Consensus CDS
    CCDS6381.1
    UniProtKB/Swiss-Prot
    Q05397
    UniProtKB/TrEMBL
    Q59GM6
    UniProtKB/TrEMBL
    Q658W2
    Related
    ENSP00000429911, OTTHUMP00000226318, ENST00000522684, OTTHUMT00000378054
    Conserved Domains (6) summary
    cd05056
    Location:415684
    Blast Score: 1513
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:9141052
    Blast Score: 671
    Focal_AT; Focal adhesion targeting region
    smart00295
    Location:36258
    Blast Score: 368
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    Blast Score: 519
    FERM_C_FAK1; Focal Adhesion Kinase 1 and 2 FERM domain C-lobe
    pfam00373
    Location:143248
    Blast Score: 141
    FERM_M; FERM central domain
    pfam07714
    Location:422676
    Blast Score: 1034
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000008.11

    Range
    140658382..141001313, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251012.1XP_005251069.1  

    See proteins identical to XP_005251069.1

    Conserved Domains (6) summary
    cd05056
    Location:456725
    Blast Score: 1513
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:9581096
    Blast Score: 673
    Focal_AT; Focal adhesion targeting region
    smart00295
    Location:36258
    Blast Score: 368
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    Blast Score: 520
    FERM_C_FAK1; Focal Adhesion Kinase 1 and 2 FERM domain C-lobe
    pfam00373
    Location:143248
    Blast Score: 141
    FERM_M; FERM central domain
    pfam07714
    Location:463717
    Blast Score: 1034
    Pkinase_Tyr; Protein tyrosine kinase
  2. XM_006716609.1XP_006716672.1  

    See proteins identical to XP_006716672.1

    Conserved Domains (6) summary
    cd05056
    Location:343612
    Blast Score: 1512
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:845983
    Blast Score: 671
    Focal_AT; Focal adhesion targeting region
    smart00295
    Location:9145
    Blast Score: 272
    B41; Band 4.1 homologues
    cd13190
    Location:141251
    Blast Score: 519
    FERM_C_FAK1; Focal Adhesion Kinase 1 and 2 FERM domain C-lobe
    pfam00373
    Location:30135
    Blast Score: 140
    FERM_M; FERM central domain
    pfam07714
    Location:350604
    Blast Score: 1033
    Pkinase_Tyr; Protein tyrosine kinase
  3. XM_006716608.1XP_006716671.1  

    See proteins identical to XP_006716671.1

    Conserved Domains (6) summary
    cd05056
    Location:456725
    Blast Score: 1513
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:9581096
    Blast Score: 673
    Focal_AT; Focal adhesion targeting region
    smart00295
    Location:36258
    Blast Score: 368
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    Blast Score: 520
    FERM_C_FAK1; Focal Adhesion Kinase 1 and 2 FERM domain C-lobe
    pfam00373
    Location:143248
    Blast Score: 141
    FERM_M; FERM central domain
    pfam07714
    Location:463717
    Blast Score: 1034
    Pkinase_Tyr; Protein tyrosine kinase
  4. XM_005251014.1XP_005251071.1  

    Conserved Domains (6) summary
    cd05056
    Location:315584
    Blast Score: 1511
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:817955
    Blast Score: 670
    Focal_AT; Focal adhesion targeting region
    smart00295
    Location:9145
    Blast Score: 272
    B41; Band 4.1 homologues
    cd13190
    Location:141251
    Blast Score: 518
    FERM_C_FAK1; Focal Adhesion Kinase 1 and 2 FERM domain C-lobe
    pfam00373
    Location:30135
    Blast Score: 140
    FERM_M; FERM central domain
    pfam07714
    Location:322576
    Blast Score: 1033
    Pkinase_Tyr; Protein tyrosine kinase
  5. XM_005251013.1XP_005251070.1  

    See proteins identical to XP_005251070.1

    Conserved Domains (6) summary
    cd05056
    Location:343612
    Blast Score: 1512
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:845983
    Blast Score: 671
    Focal_AT; Focal adhesion targeting region
    smart00295
    Location:9145
    Blast Score: 272
    B41; Band 4.1 homologues
    cd13190
    Location:141251
    Blast Score: 519
    FERM_C_FAK1; Focal Adhesion Kinase 1 and 2 FERM domain C-lobe
    pfam00373
    Location:30135
    Blast Score: 140
    FERM_M; FERM central domain
    pfam07714
    Location:350604
    Blast Score: 1033
    Pkinase_Tyr; Protein tyrosine kinase
  6. XM_006716610.1XP_006716673.1  

    See proteins identical to XP_006716673.1

    Conserved Domains (6) summary
    cd05056
    Location:343612
    Blast Score: 1512
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:845983
    Blast Score: 671
    Focal_AT; Focal adhesion targeting region
    smart00295
    Location:9145
    Blast Score: 272
    B41; Band 4.1 homologues
    cd13190
    Location:141251
    Blast Score: 519
    FERM_C_FAK1; Focal Adhesion Kinase 1 and 2 FERM domain C-lobe
    pfam00373
    Location:30135
    Blast Score: 140
    FERM_M; FERM central domain
    pfam07714
    Location:350604
    Blast Score: 1033
    Pkinase_Tyr; Protein tyrosine kinase
  7. XM_006716606.1XP_006716669.1  

    Conserved Domains (6) summary
    cd05056
    Location:469738
    Blast Score: 1512
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:9711109
    Blast Score: 673
    Focal_AT; Focal adhesion targeting region
    smart00295
    Location:49271
    Blast Score: 368
    B41; Band 4.1 homologues
    cd13190
    Location:267377
    Blast Score: 520
    FERM_C_FAK1; Focal Adhesion Kinase 1 and 2 FERM domain C-lobe
    pfam00373
    Location:156261
    Blast Score: 141
    FERM_M; FERM central domain
    pfam07714
    Location:476730
    Blast Score: 1033
    Pkinase_Tyr; Protein tyrosine kinase
  8. XM_005251009.1XP_005251066.1  

    Conserved Domains (6) summary
    cd05056
    Location:464733
    Blast Score: 1511
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:9661104
    Blast Score: 673
    Focal_AT; Focal adhesion targeting region
    smart00295
    Location:80302
    Blast Score: 369
    B41; Band 4.1 homologues
    cd13190
    Location:298372
    Blast Score: 316
    FERM_C_FAK1; Focal Adhesion Kinase 1 and 2 FERM domain C-lobe
    pfam00373
    Location:187292
    Blast Score: 141
    FERM_M; FERM central domain
    pfam07714
    Location:471725
    Blast Score: 1032
    Pkinase_Tyr; Protein tyrosine kinase
  9. XM_005251011.1XP_005251068.1  

    UniProtKB/TrEMBL
    E7ESA6
    Related
    ENSP00000429082, OTTHUMP00000226325, ENST00000517887, OTTHUMT00000378062
    Conserved Domains (6) summary
    cd05056
    Location:459728
    Blast Score: 1512
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:9581096
    Blast Score: 673
    Focal_AT; Focal adhesion targeting region
    smart00295
    Location:80302
    Blast Score: 368
    B41; Band 4.1 homologues
    cd13190
    Location:298408
    Blast Score: 520
    FERM_C_FAK1; Focal Adhesion Kinase 1 and 2 FERM domain C-lobe
    pfam00373
    Location:187292
    Blast Score: 141
    FERM_M; FERM central domain
    pfam07714
    Location:466720
    Blast Score: 1033
    Pkinase_Tyr; Protein tyrosine kinase
  10. XM_006716607.1XP_006716670.1  

    Conserved Domains (6) summary
    cd05056
    Location:459728
    Blast Score: 1512
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:9611099
    Blast Score: 673
    Focal_AT; Focal adhesion targeting region
    smart00295
    Location:80302
    Blast Score: 369
    B41; Band 4.1 homologues
    cd13190
    Location:298408
    Blast Score: 520
    FERM_C_FAK1; Focal Adhesion Kinase 1 and 2 FERM domain C-lobe
    pfam00373
    Location:187292
    Blast Score: 141
    FERM_M; FERM central domain
    pfam07714
    Location:466720
    Blast Score: 1033
    Pkinase_Tyr; Protein tyrosine kinase
  11. XM_005251010.1XP_005251067.1  

    Conserved Domains (6) summary
    cd05056
    Location:466735
    Blast Score: 1512
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:9651103
    Blast Score: 673
    Focal_AT; Focal adhesion targeting region
    smart00295
    Location:80302
    Blast Score: 368
    B41; Band 4.1 homologues
    cd13190
    Location:298408
    Blast Score: 520
    FERM_C_FAK1; Focal Adhesion Kinase 1 and 2 FERM domain C-lobe
    pfam00373
    Location:187292
    Blast Score: 140
    FERM_M; FERM central domain
    pfam07714
    Location:473727
    Blast Score: 1033
    Pkinase_Tyr; Protein tyrosine kinase
  12. XM_005251007.1XP_005251064.1  

    Conserved Domains (6) summary
    cd05056
    Location:466735
    Blast Score: 1512
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:9681106
    Blast Score: 673
    Focal_AT; Focal adhesion targeting region
    smart00295
    Location:80302
    Blast Score: 369
    B41; Band 4.1 homologues
    cd13190
    Location:298408
    Blast Score: 520
    FERM_C_FAK1; Focal Adhesion Kinase 1 and 2 FERM domain C-lobe
    pfam00373
    Location:187292
    Blast Score: 141
    FERM_M; FERM central domain
    pfam07714
    Location:473727
    Blast Score: 1033
    Pkinase_Tyr; Protein tyrosine kinase
  13. XM_005251008.1XP_005251065.1  

    Conserved Domains (6) summary
    cd05056
    Location:465734
    Blast Score: 1512
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:9671105
    Blast Score: 673
    Focal_AT; Focal adhesion targeting region
    smart00295
    Location:80302
    Blast Score: 369
    B41; Band 4.1 homologues
    cd13190
    Location:298408
    Blast Score: 520
    FERM_C_FAK1; Focal Adhesion Kinase 1 and 2 FERM domain C-lobe
    pfam00373
    Location:187292
    Blast Score: 141
    FERM_M; FERM central domain
    pfam07714
    Location:472726
    Blast Score: 1033
    Pkinase_Tyr; Protein tyrosine kinase
  14. XM_005251006.1XP_005251063.1  

    Conserved Domains (6) summary
    cd05056
    Location:472741
    Blast Score: 1512
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:9741112
    Blast Score: 673
    Focal_AT; Focal adhesion targeting region
    smart00295
    Location:80302
    Blast Score: 369
    B41; Band 4.1 homologues
    cd13190
    Location:298408
    Blast Score: 520
    FERM_C_FAK1; Focal Adhesion Kinase 1 and 2 FERM domain C-lobe
    pfam00373
    Location:187292
    Blast Score: 141
    FERM_M; FERM central domain
    pfam07714
    Location:479733
    Blast Score: 1033
    Pkinase_Tyr; Protein tyrosine kinase
  15. XM_005251005.1XP_005251062.1  

    Conserved Domains (6) summary
    cd05056
    Location:493762
    Blast Score: 1512
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:9951133
    Blast Score: 673
    Focal_AT; Focal adhesion targeting region
    smart00295
    Location:80302
    Blast Score: 369
    B41; Band 4.1 homologues
    cd13190
    Location:298408
    Blast Score: 520
    FERM_C_FAK1; Focal Adhesion Kinase 1 and 2 FERM domain C-lobe
    pfam00373
    Location:187292
    Blast Score: 141
    FERM_M; FERM central domain
    pfam07714
    Location:500754
    Blast Score: 1033
    Pkinase_Tyr; Protein tyrosine kinase
  16. XM_005251004.1XP_005251061.1  

    Conserved Domains (6) summary
    cd05056
    Location:500769
    Blast Score: 1513
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:9991137
    Blast Score: 673
    Focal_AT; Focal adhesion targeting region
    smart00295
    Location:80302
    Blast Score: 368
    B41; Band 4.1 homologues
    cd13190
    Location:298408
    Blast Score: 520
    FERM_C_FAK1; Focal Adhesion Kinase 1 and 2 FERM domain C-lobe
    pfam00373
    Location:187292
    Blast Score: 141
    FERM_M; FERM central domain
    pfam07714
    Location:507761
    Blast Score: 1033
    Pkinase_Tyr; Protein tyrosine kinase
  17. XM_005251003.1XP_005251060.1  

    Conserved Domains (6) summary
    cd05056
    Location:500769
    Blast Score: 1512
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:10021140
    Blast Score: 673
    Focal_AT; Focal adhesion targeting region
    smart00295
    Location:80302
    Blast Score: 369
    B41; Band 4.1 homologues
    cd13190
    Location:298408
    Blast Score: 520
    FERM_C_FAK1; Focal Adhesion Kinase 1 and 2 FERM domain C-lobe
    pfam00373
    Location:187292
    Blast Score: 141
    FERM_M; FERM central domain
    pfam07714
    Location:507761
    Blast Score: 1033
    Pkinase_Tyr; Protein tyrosine kinase

Alternate HuRef

Genomic

  1. AC_000140.1 Alternate HuRef

    Range
    136979065..137322195, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    141708729..142051666, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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