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    FAM40B family with sequence similarity 40, member B [ Homo sapiens ]

    Gene ID: 57464, updated on 11-May-2012
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    Summary

    Official Symbol
    FAM40Bprovided by HGNC
    Official Full Name
    family with sequence similarity 40, member Bprovided by HGNC
    Primary source
    HGNC:22209
    See related
    Ensembl:ENSG00000128578; HPRD:16880; Vega:OTTHUMG00000157695
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
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    Genomic context

    Location :
    7q32.1
    Sequence :
    Chromosome: 7; NC_000007.13 (129074274..129128240)
    See FAM40B in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene adenosylhomocysteinase-like 2 Neighboring gene RNA, U7 small nuclear 16 pseudogene Neighboring gene cell division cycle 26 homolog (S. cerevisiae) pseudogene 1 Neighboring gene uncharacterized LOC100287482 Neighboring gene uncharacterized LOC100127891

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    2. Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
    3. An integrated workflow for charting the human interaction proteome: insights into the PP2A system. Glatter T, et al. Mol Syst Biol, 2009. PMID 19156129.
    4. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Goudreault M, et al. Mol Cell Proteomics, 2009 Jan. PMID 18782753.
    5. The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901.

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:121534 BioGRID:123842 CTTNBP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121534 BioGRID:121000 CTTNBP2NL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121534 BioGRID:124497 FAM40A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121534 BioGRID:117369 MOB4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121534 BioGRID:119722 MST4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121534 BioGRID:123136 SIKE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121534 BioGRID:114011 STK24    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121534 BioGRID:115757 STK25    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121534 BioGRID:112674 STRN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121534 BioGRID:118999 STRN3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121534 BioGRID:123249 TRAF3IP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121534 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121534 BioGRID:120139 ZRANB1    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		  
    cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
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    General protein information

    Preferred Names
    protein FAM40B
    Names
    protein FAM40B
    homolog of yeast FAR11 protein 2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134336.1 → NP_001127808.1  protein FAM40B isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      BC019064, DA409007
      Consensus CDS
      CCDS47709.1
      UniProtKB/Swiss-Prot
      Q9ULQ0
      Related
      ENSP00000392393, OTTHUMP00000212367, ENST00000435494, OTTHUMT00000349419
      Conserved Domains (2) summary
      pfam11882
      Location:416 – 751
      Blast Score: 890
      DUF3402; Domain of unknown function (DUF3402)
      pfam07923
      Location:48 – 353
      Blast Score: 724
      N1221; N1221-like protein

    2. NM_020704.2 → NP_065755.1  protein FAM40B isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AB032996, AC009244, DA409007
      Consensus CDS
      CCDS34752.1
      UniProtKB/Swiss-Prot
      Q9ULQ0
      Related
      ENSP00000249344, OTTHUMP00000212366, ENST00000249344, OTTHUMT00000349418
      Conserved Domains (2) summary
      pfam11882
      Location:416 – 786
      Blast Score: 1002
      DUF3402; Domain of unknown function (DUF3402)
      pfam07923
      Location:48 – 353
      Blast Score: 720
      N1221; N1221-like protein

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      129074274..129128240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      123435594..123489594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      128458245..128512203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC009244.25 (68137..122078) None
    genomic CH236950.1 EAL24101.1
    genomic CH471070.1 EAW83719.1
      EAW83720.1
    mRNA AB032996.1 BAA86484.1
    mRNA AK290165.1 BAF82854.1
    mRNA AK302339.1 BAH13679.1
    mRNA BC019064.2 AAH19064.1
    mRNA DA409007.1 None
    other-genetic AM392619.1 CAL37497.1
    other-genetic AM392944.1 CAL37822.1
    other-genetic AM392960.1 CAL37838.1
    other-genetic AM393447.1 CAL38325.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULQ0.2 GenPept UniProtKB/Swiss-Prot:Q9ULQ0
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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