SCYL1 SCY1-like 1 (S. cerevisiae) [Homo sapiens] - Gene

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Summary

Official Symbol: SCYL1provided by HGNC
Official Full Name: SCY1-like 1 (S. cerevisiae)provided by HGNC
Primary source: HGNC:14372
Locus tag: HT019
See related: Ensembl:ENSG00000142186; HPRD:06414; MIM:607982; Vega:OTTHUMG00000166325
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GKLP; NKTL; NTKL; P105; TAPK; TEIF; TRAP; HT019; MGC78454
Summary: This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 11q13

Sequence :: Chromosome: 11; NC_000011.9 (65292548..65306182)

See SCYL1 in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TEIF protein and centrosome amplification is commonly found in colorectal tumors. The expression level of TEIF is related to tumor histological grade and malignant degree.
Title: [Expression of TEIF protein in colorectal tumors and its correlation with centrosome abnormality].
Scyl1 interacts with 58K/formiminotransferase cyclodeaminase (FTCD) and golgin p115, and is required for the maintenance of Golgi morphology
Title: Scyl1 regulates Golgi morphology.
Scyl1 participates in the nuclear aminoacylation-dependent tRNA export pathway.
Title: Scyl1 facilitates nuclear tRNA export in mammalian cells by acting at the nuclear pore complex.
SCYL1-BP1 can be ubiquitinated and degraded by Pirh2 but not by MDM2, which suggests that SCYL1-BP1 can be regulated by Pirh2.
Title: A newly identified Pirh2 substrate SCYL1-BP1 can bind to MDM2 and accelerate MDM2 self-ubiquitination.
TEIF functions as a centrosome regulator. Its participation in DNA damage response, including telomere dysfunction and tumorigenesis.
Title: Localization of TEIF in the centrosome and its functional association with centrosome amplification in DNA damage, telomere dysfunction and human cancers.
TEIF could specifically activate transcription of beta-pol promoter, but not that of DNA polymerase alpha or delta promoter. The responsible sequences for binding of TEIF were revealed
Title: Transcriptional upregulation of DNA polymerase beta by TEIF.
NTKL is involved in centrosome-related cellular functions
Title: Identification and characterization of the human protein kinase-like gene NTKL: mitosis-specific centrosomal localization of an alternatively spliced isoform.
Molecular cloning of telomerase transcriptional elements-interacting factor,(TEIF). TEIF may take part in the transcriptional activation of hTERT.
Title: Molecular cloning and characterization of a human gene involved in transcriptional regulation of hTERT.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

A genome-wide association study of optic disc parameters.

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_065731.2	NP_036204.1	CD93	BIND	PubMed	CD93 interacts with p105.
Q96KG9	Q9NPY3	CD93	HPRD	PubMed
Q96KG9	P38432	COIL	HPRD	PubMed
Q96KG9	Q5T7V8	GORAB	HPRD	PubMed
Q96KG9	Q96KG9	SCYL1	HPRD	PubMed

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
DNA binding	IEA Inferred from Electronic Annotation more info
binding	IEA Inferred from Electronic Annotation more info
protein tyrosine kinase activity	NAS Non-traceable Author Statement more info	PubMed
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
retrograde vesicle-mediated transport, Golgi to ER	IDA Inferred from Direct Assay more info	PubMed
vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
COPI vesicle coat	IDA Inferred from Direct Assay more info	PubMed
Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
cis-Golgi network	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
cytoskeleton	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum-Golgi intermediate compartment	IDA Inferred from Direct Assay more info	PubMed
microtubule organizing center	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: N-terminal kinase-like protein

Names: N-terminal kinase-like protein; SCY1-like protein 1; teratoma-associated tyrosine kinase; telomerase regulation-associated protein; coated vesicle-associated kinase of 90 kDa; telomerase transcriptional element-interacting factor; telomerase transcriptional elements-interacting factor; likely ortholog of mouse N-terminal kinase-like protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048218.1 → NP_001041683.1 N-terminal kinase-like protein isoform B

Status: REVIEWED

Description

Transcript Variant: This variant (B), also known as 1, uses an alternate in-frame splice site in the 3' coding region, compared to variant A. It encodes isoform B, which is shorter than isoform A.

Source sequence(s)

AB051428, BP281963, BU728709

Consensus CDS

CCDS44646.1

UniProtKB/Swiss-Prot

Q96KG9

Related

ENSP00000408192, OTTHUMP00000232621, ENST00000420247, OTTHUMT00000389163

Conserved Domains (1) summary

cl09925
Location:32 – 260
Blast Score: 171

PKc_like; Protein Kinases, catalytic domain
NM_020680.3 → NP_065731.3 N-terminal kinase-like protein isoform A

Status: REVIEWED

Description

Transcript Variant: This variant (A) represents the longer transcript and encodes the longer isoform (A).

Source sequence(s)

BC069233, BP281963, BU728709

Consensus CDS

CCDS41672.1

UniProtKB/Swiss-Prot

Q96KG9

Related

ENSP00000270176, OTTHUMP00000232619, ENST00000270176, OTTHUMT00000389159

Conserved Domains (1) summary

cl09925
Location:32 – 260
Blast Score: 170

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p5 Primary Assembly

Range

65292548..65306182

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

61619558..61633190

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF255613.1	AAF81422.1
genomic	AP000769.5 (90984..104576)	None
genomic	CH471076.1	EAW74395.1
		EAW74396.1
		EAW74397.1
		EAW74398.1
		EAW74399.1
		EAW74400.1
mRNA	AB047077.1	BAB55454.1
mRNA	AB051427.1	BAB55458.1
mRNA	AB051428.1	BAB55459.1
mRNA	AF225424.1	AAG09726.1
mRNA	AF297709.1	AAG17902.1
mRNA	AK302198.1	BAG63559.1
mRNA	AK314945.1	None
mRNA	BC009967.2	AAH09967.2
mRNA	BC069233.1	AAH69233.1
mRNA	BP281963.1	None
mRNA	BU728709.1	None