U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TLR1 toll-like receptor 1 [ Bos taurus (cattle) ]

Gene ID: 574090, updated on 7-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
TLR1
Gene description
toll-like receptor 1
See related
BGD:BT10088
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information
not in current annotation release
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 6

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Polymorphisms in toll-like receptor (TLR) 1, 4, 9 and SLC11A1 genes and their association with paratuberculosis susceptibility in Holstein and indigenous crossbred cattle in Turkey. Ulas Cinar M, et al. J Genet, 2018 Dec. PMID 30555064
  2. Identification of single nucleotide polymorphisms in the bovine Toll-like receptor 1 gene and association with health traits in cattle. Russell CD, et al. Vet Res, 2012 Mar 14. PMID 22417166, Free PMC Article
  3. Association of TLR gene variants in a Czech Red Pied cattle population with reproductive traits. Bjelka M, et al. Vet Immunol Immunopathol, 2020 Feb. PMID 31901560
  4. Polymorphisms in toll-like receptor 1 and 9 genes and their association with tuberculosis susceptibility in Chinese Holstein cattle. Sun L, et al. Vet Immunol Immunopathol, 2012 Jun 30. PMID 22572235
  5. Identification of full length bovine TLR1 and functional characterization of lipopeptide recognition by bovine TLR2/1 heterodimer. Farhat K, et al. Vet Res, 2010 May-Jun. PMID 20167196, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association of TLR gene variants in a Czech Red Pied cattle population with reproductive traits.
    Title: Association of TLR gene variants in a Czech Red Pied cattle population with reproductive traits.
  2. Polymorphisms in toll-like receptor 1 is associated with paratuberculosis susceptibility.
    Title: Polymorphisms in toll-like receptor (TLR) 1, 4, 9 and SLC11A1 genes and their association with paratuberculosis susceptibility in Holstein and indigenous crossbred cattle in Turkey.
  3. There is an association between single nucleotide polymorphisms (SNPs), common to boTLR1, and clinical mastitis susceptibility. Furthermore, some of these SNPs underpin functional variation in boTLR1.
    Title: Identification of single nucleotide polymorphisms in the bovine Toll-like receptor 1 gene and association with health traits in cattle.
  4. TLR2, TLR1, and TLR6 haev roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides by epithelial and stromal cells of bovine endometrium
    Title: Epithelial and stromal cells of bovine endometrium have roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides in vitro via Toll-like receptors TLR2, TLR1, and TLR6.
  5. variants in the TLR1 gene are associated with susceptibility to bovine tuberculosis, whereas no significant association can be inferred from the polymorphisms in the TLR9 gene
    Title: Polymorphisms in toll-like receptor 1 and 9 genes and their association with tuberculosis susceptibility in Chinese Holstein cattle.
  6. Whereas previous results regarding the TLR1 gene were not corroborated, a risk haplotype was detected in TLR2; however, its low frequency indicates that this detected association should be interpreted with caution.
    Title: Genetic variation of toll-like receptor genes and infection by Mycobacterium avium ssp. paratuberculosis in Holstein-Friesian cattle.
  7. This study showed that TLR1 and TLR2 together are necessary for the recognition of triacylated lipopeptides.
    Title: Identification of full length bovine TLR1 and functional characterization of lipopeptide recognition by bovine TLR2/1 heterodimer.
  8. Prediction and comparison of TLR protein domain architectures for multiple species revealed seven conserved regions of LRR patterning associated with the three genes investigated.
    Title: Sequence variability and protein domain architectures for bovine Toll-like receptors 1, 5, and 10.
  9. The expression analysis showed similar expression profiles for TLR1 and TLR6, which indicate a co-regulation of these two genes, TLR10 had a different expression profile, pointing toward a stronger functional diversification compared to TLR1 and TLR6.
    Title: Genomic organization and transcript profiling of the bovine toll-like receptor gene cluster TLR6-TLR1-TLR10.
Submit: New GeneRIF Correction

General protein information

Go to the top of the page Help
Preferred Names
toll-like receptor 1
Names
Toll-like receptor 1 long form
NP_001039969.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001046504.1 → NP_001039969.1  toll-like receptor 1

    See identical proteins and their annotated locations for NP_001039969.1

    Status: PROVISIONAL

    Source sequence(s)
    AY634628
    UniProtKB/TrEMBL
    A7YK65, A7YK67, Q6GV21
    Conserved Domains (5) summary
    smart00082
    Location:463 → 516
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:575 → 718
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:10 → 33
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:291 → 312
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:8 → 65
    LRR_8; Leucine rich repeat
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.