CLK4 CDC-like kinase 4 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: CLK4provided by HGNC
Official Full Name: CDC-like kinase 4provided by HGNC
Primary source: HGNC:13659
See related: Ensembl:ENSG00000113240; HPRD:12140; MIM:607969; Vega:OTTHUMG00000130893
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DKFZp686A20267
Summary: The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]

Help top of page

Genomic context

Location :: 5q35

Sequence :: Chromosome: 5; NC_000005.9 (178029665..178054054, complement)

See CLK4 in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.
Title: Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.

Submit: New GeneRIF Correction

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
Q9HAZ1	Q8N2M8	CLASRP	HPRD	PubMed
Q9HAZ1	Q9HAZ1	CLK4	HPRD	PubMed
Q9HAZ1	Q16082	HSPB2	HPRD	PubMed
Q9HAZ1	Q9BZL1	UBL5	HPRD	PubMed
BioGRID:121501	BioGRID:116302	CLASRP	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:121501	BioGRID:116817	JMJD6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:121501	BioGRID:121872	UBL5	BioGRID	PubMed	Reconstituted Complex; Two-hybrid

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
protein autophosphorylation	IEA Inferred from Electronic Annotation more info
regulation of RNA splicing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: dual specificity protein kinase CLK4

Names: dual specificity protein kinase CLK4; protein serine threonine kinase Clk4

NP_065717.1

EC 2.7.12.1

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020666.2 → NP_065717.1 dual specificity protein kinase CLK4

Status: REVIEWED

Source sequence(s)

BC015942, BC063116, CB127989

Consensus CDS

CCDS4437.1

UniProtKB/Swiss-Prot

Q9HAZ1

Related

ENSP00000316948, OTTHUMP00000161494, ENST00000316308, OTTHUMT00000253479

Conserved Domains (2) summary

smart00220
Location:159 – 475
Blast Score: 583

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl09925
Location:159 – 475
Blast Score: 409

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p5 Primary Assembly

Range

178029665..178054054, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

172756811..172777551, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC022096.7 (81997..106386)	None
genomic	CH471165.2	EAW53831.1
		EAW53832.1
mRNA	AF294429.1	AAG10074.1
mRNA	AK304614.1	BAH14226.1
mRNA	AK308674.1	None
mRNA	AK308879.1	None
mRNA	AK310427.1	None
mRNA	AK311485.1	None
mRNA	BC015942.1	None
mRNA	BC034633.1	AAH34633.1
mRNA	BC046211.1	None
mRNA	BC063116.1	None
mRNA	BC065732.1	AAH65732.1
mRNA	BC136261.1	AAI36262.1
mRNA	BC143538.1	None
mRNA	BC143547.1	AAI43548.1
mRNA	BC151233.1	None
mRNA	BX647323.1	None
mRNA	CB127989.1	None
mRNA	CR749504.1	CAH18325.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q4G0Z5	GenPept	UniProtKB/TrEMBL:Q4G0Z5
Q68D95	GenPept	UniProtKB/TrEMBL:Q68D95
Q6P090	GenPept	UniProtKB/TrEMBL:Q6P090
Q9HAZ1.1	GenPept	UniProtKB/Swiss-Prot:Q9HAZ1