RHOJ ras homolog family member J [Homo sapiens] - Gene

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Summary

Official Symbol: RHOJprovided by HGNC
Official Full Name: ras homolog family member Jprovided by HGNC
Primary source: HGNC:688
See related: Ensembl:ENSG00000126785; HPRD:09632; MIM:607653; Vega:OTTHUMG00000140342
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TCL; ARHJ; TC10B; RASL7B; FLJ14445; MGC34777
Summary: This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. [provided by RefSeq, Dec 2011]

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Genomic context

Location :: 14q23.2

Sequence :: Chromosome: 14; NC_000014.8 (63671145..63758559)

See RHOJ in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our study supports a novel role for the Rho family member RhoJ in ednothelial cell morphogenesis and in particular in lumen formation
Title: RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG.
RhoJ is endothelial-expressed in vivo, activated by vascular endothelial growth factor, localizes to focal adhesions, regulates endothelial cell migration and tube formation, and modulates actomyosin contractility and focal adhesion numbers.
Title: RhoJ/TCL regulates endothelial motility and tube formation and modulates actomyosin contractility and focal adhesion numbers.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
TCL is essential for clathrin-dependent endocytosed receptors to enter the early/sorting endosomes
Title: The GTP/GDP cycling of rho GTPase TCL is an essential regulator of the early endocytic pathway.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_065714.1			BIND	PubMed	GTP binds to the GTPase TCL.
NP_065714.1			BIND	PubMed	GDP binds to the GTPase TCL.
Q9H4E5	Q04771	ACVR1	HPRD	PubMed
Q9H4E5	O00238	BMPR1B	HPRD	PubMed
Q9H4E5	P60953	CDC42	HPRD	PubMed
Q9H4E5	Q96BY6	DOCK10	HPRD	PubMed
Q9H4E5	Q8NF50	DOCK8	HPRD	PubMed
Q9H4E5	Q13153	PAK1	HPRD	PubMed
Q9H4E5	Q15796	SMAD2	HPRD	PubMed
Q9H4E5	Q13485	SMAD4	HPRD	PubMed
Q9H4E5	P36897	TGFBR1	HPRD	PubMed
Q9H4E5	P42768	WAS	HPRD	PubMed
BioGRID:121499	BioGRID:111095	PAK1	BioGRID	PubMed	Two-hybrid
BioGRID:121499	BioGRID:113293	WAS	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
GTP binding	IEA Inferred from Electronic Annotation more info
GTPase activity	NAS Non-traceable Author Statement more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
GTP catabolic process	NAS Non-traceable Author Statement more info	PubMed
Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cell shape	IEA Inferred from Electronic Annotation more info
regulation of small GTPase mediated signal transduction	TAS Traceable Author Statement more info
small GTPase mediated signal transduction	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cellular_component	ND No biological Data available more info
cytosol	TAS Traceable Author Statement more info
intracellular	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: rho-related GTP-binding protein RhoJ

Names: rho-related GTP-binding protein RhoJ; TC10-like Rho GTPase; RAS-like, family 7, member B; tc10-like GTP-binding protein; ras homolog gene family, member J; ras-like protein family member 7B

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020663.4 → NP_065714.1 rho-related GTP-binding protein RhoJ precursor

Status: VALIDATED

Source sequence(s)

AF087862, AK027351, AL049871, BM555132

Consensus CDS

CCDS9757.1

UniProtKB/TrEMBL

Q7Z513

UniProtKB/Swiss-Prot

Q9H4E5

Related

ENSP00000316729, OTTHUMP00000179059, ENST00000316754, OTTHUMT00000276975

Conserved Domains (2) summary

COG1100
Location:19 – 214
Blast Score: 316

COG1100; GTPase SAR1 and related small G proteins [General function prediction only]

cl09099
Location:22 – 195
Blast Score: 870

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p5 Primary Assembly

Range

63671145..63758559

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

43837568..43924973

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL049871.4 (37388..126474)	None
genomic	CH471061.1	EAW80820.1
		EAW80821.1
		EAW80822.1
		EAW80823.1
		EAW80824.1
mRNA	AB209218.1	BAD92455.1
mRNA	AF087862.1	AAP97172.1
mRNA	AF309563.1	AAL09440.1
mRNA	AF498977.1	AAM21124.1
mRNA	AJ276567.1	CAC06611.1
mRNA	AK027278.1	BAB55013.1
mRNA	AK027351.1	BAB55055.1
mRNA	BC025770.1	None
mRNA	BC062575.1	AAH62575.1
mRNA	BM555132.1	None
other-genetic	HQ448081.1	ADQ32562.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q59G91	GenPept	UniProtKB/TrEMBL:Q59G91
Q7Z513	GenPept	UniProtKB/TrEMBL:Q7Z513
Q9H4E5.1	GenPept	UniProtKB/Swiss-Prot:Q9H4E5