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MRS2 MRS2 magnesium transporter [ Homo sapiens (human) ]

Gene ID: 57380, updated on 26-Jun-2015
Official Symbol
MRS2provided by HGNC
Official Full Name
MRS2 magnesium transporterprovided by HGNC
Primary source
HGNC:HGNC:13785
See related
Ensembl:ENSG00000124532; HPRD:17603; Vega:OTTHUMG00000014355
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPT; MRS2L
Orthologs
See MRS2 in Epigenomics, MapViewer
Location:
6p22.3-p22.1
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (24402908..24426194)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (24403141..24425816)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene neurensin 1 Neighboring gene doublecortin domain containing 2 Neighboring gene kidney associated antigen 1 Neighboring gene glycosylphosphatidylinositol specific phospholipase D1 Neighboring gene aldehyde dehydrogenase 5 family, member A1 Neighboring gene KIAA0319 Neighboring gene keratin 8 pseudogene 43

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of MRS2 magnesium homeostasis factor homolog by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev is identified to have a physical interaction with magnesium homeostasis factor homolog (MRS2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC78523

Gene Ontology Provided by GOA

Function Evidence Code Pubs
magnesium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
cation transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrial magnesium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
 
transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
Preferred Names
magnesium transporter MRS2 homolog, mitochondrial
Names
magnesium transporter MRS2 homolog, mitochondrial
MRS2-like protein
MRS2-like, magnesium homeostasis factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286264.1NP_001273193.1  magnesium transporter MRS2 homolog, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_001273193.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AA836333, AF293076, AK298849, AL359713, BM829320
    Consensus CDS
    CCDS69055.1
    UniProtKB/Swiss-Prot
    Q9HD23
    Related
    ENSP00000399585, ENST00000443868
    Conserved Domains (1) summary
    cd12823
    Location:88402
    Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family
  2. NM_001286265.1NP_001273194.1  magnesium transporter MRS2 homolog, mitochondrial isoform c

    See identical proteins and their annotated locations for NP_001273194.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon and uses an alternate splice site, which results in an alternate in-frame segment in the 5' coding region, and it contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AA828962, BC069009, BM680865, BM829320
    Consensus CDS
    CCDS75408.1
    UniProtKB/Swiss-Prot
    Q9HD23
    Related
    ENSP00000367604, OTTHUMP00000016086, ENST00000378353, OTTHUMT00000040003
    Conserved Domains (1) summary
    cd12823
    Location:88399
    Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family
  3. NM_001286266.1NP_001273195.1  magnesium transporter MRS2 homolog, mitochondrial isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three exons and uses an alternate splice site, which results in the loss of an in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AA836333, AF293076, AK299825, AL359713, BM829320, DC305123
    Consensus CDS
    CCDS69056.1
    UniProtKB/TrEMBL
    A0A0A0MQX2
    UniProtKB/TrEMBL
    B4DSN2
    UniProtKB/Swiss-Prot
    Q9HD23
    Related
    ENSP00000274747, ENST00000274747
    Conserved Domains (1) summary
    cd12823
    Location:89349
    Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family
  4. NM_020662.3NP_065713.1  magnesium transporter MRS2 homolog, mitochondrial isoform b precursor

    See identical proteins and their annotated locations for NP_065713.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and uses an alternate splice site, which results in an alternate in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AA836333, AF293076, AK291058, AL359713, BM829320
    Consensus CDS
    CCDS4552.1
    UniProtKB/Swiss-Prot
    Q9HD23
    Related
    ENSP00000367637, OTTHUMP00000016085, ENST00000378386, OTTHUMT00000040002
    Conserved Domains (1) summary
    cd12823
    Location:88399
    Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family

RNA

  1. NR_104423.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two exons and uses two alternate splice sites in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA836333, AF293076, AK297418, AL359713, BM829320

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    24402908..24426194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249242.1XP_005249299.1  

    Conserved Domains (1) summary
    cd12823
    Location:88369
    Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    24407373..24430657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)