Ppbp pro-platelet basic protein [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Ppbpprovided by MGI
Official Full Name: pro-platelet basic proteinprovided by MGI
Primary source: MGI:1888712
See related: Ensembl:ENSMUSG00000029372
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TGB; LDGF; MDGF; TGB1; CTAP3; Cxcl7; NAP-2; Scyb7; b-TG1; LA-PF4; THBGB1; CTAPIII; beta-TG; AI854500; NAP-2-L1; 2400003M24Rik

Genomic context

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Location :: 5 E1; 5

Sequence :: Chromosome: 5; NC_000071.6 (90768518..90770060)

See Ppbp in Epigenomics, MapViewer

Chromosome 5 - NC_000071.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that Cxcl4 and Cxcl7 play a role in the development of neurobehavioral alterations that are triggered by in utero TCDD exposure and later surface in adults.
Title: Fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces expression of the chemokine genes Cxcl4 and Cxcl7 in the perinatal mouse brain.

Submit: New GeneRIF Correction

Pathways from BioSystems

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Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
Chemokine receptors bind chemokines, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Chemokine signaling pathway, organism-specific biosystem (from KEGG)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, organism-specific biosystem (from WikiPathways)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, conserved biosystem (from KEGG)
Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
G alpha (i) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
Peptide ligand-binding receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Platelet degranulation, organism-specific biosystem (from REACTOME)
Platelet degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
Response to elevated platelet cytosolic Ca2+, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

AI854500 (e-PCR)
- UniSTS:179201

NoName (e-PCR)
- UniSTS:487567

PMC129049P2 (e-PCR)
- UniSTS:270582

Homology

Homologs of the Ppbp gene: The Ppbp gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: platelet basic protein

Names: platelet basic protein; chemokine (C-X-C motif) ligand 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023785.2 → NP_076274.1 platelet basic protein precursor

Status: PROVISIONAL

Source sequence(s)

AF219112

Consensus CDS

CCDS19415.1

UniProtKB/TrEMBL

Q9EQI5

Related

ENSMUSP00000031319, ENSMUST00000031319

Conserved Domains (1) summary

cd00273
Location:49 – 111
Blast Score: 202

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 129S1/SvImJ

Genomic

NT_109599.1 Reference GRCm38.p1 129S1/SvImJ

Range

56669..58211, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000071.6 Reference GRCm38.p1 C57BL/6J

Range

90768518..90770060

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000027.1 Alternate Mm_Celera

Range

88920145..88921687

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01046745.1 (20538..22080)	None
genomic	AC105995.9 (90343..91885)	None
genomic	AC113262.29 (56668..58210)	None	129/Sv
genomic	AF349465.1	AAK30162.1
genomic	CH466617.2	EDL05307.1	mixed
		EDL05308.1	mixed
mRNA	AB042817.1	BAB83941.1
mRNA	AF219112.1	AAG36786.1
mRNA	AF278700.1	AAK69476.1
mRNA	AK010273.1	BAB26811.1	C57BL/6J
mRNA	AK157077.1	BAE33955.1	NOD
mRNA	AK157141.1	BAE33977.1	NOD
mRNA	AK158061.1	BAE34343.1	C57BL/6J
mRNA	AK171720.1	BAE42631.1	NOD
mRNA	BC127043.1	AAI27044.1
mRNA	BC127044.1	AAI27045.1