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KAT14 lysine acetyltransferase 14 [ Homo sapiens (human) ]

Gene ID: 57325, updated on 8-May-2016
Official Symbol
KAT14provided by HGNC
Official Full Name
lysine acetyltransferase 14provided by HGNC
Primary source
HGNC:HGNC:15904
See related
Ensembl:ENSG00000149474 HPRD:16765; Vega:OTTHUMG00000031962
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATAC2; CRP2BP; CSRP2BP; PRO1194; dJ717M23.1
Summary
CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]
Orthologs
Location:
20p11.23
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 20 NC_000020.11 (18142224..18188387)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (18122868..18169031)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ovo like zinc finger 2 Neighboring gene ribosomal protein L15 pseudogene 1 Neighboring gene PET117 homolog Neighboring gene gamma-glutamylcyclotransferase pseudogene Neighboring gene uncharacterized LOC105372551

NHGRI GWAS Catalog

Description
A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.
NHGRI GWA Catalog
  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • HATs acetylate histones, organism-specific biosystem (from REACTOME)
    HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC15388

Gene Ontology Provided by GOA

Function Evidence Code Pubs
LIM domain binding NAS
Non-traceable Author Statement
more info
PubMed 
histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Ada2/Gcn5/Ada3 transcription activator complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IPI
Inferred from Physical Interaction
more info
PubMed 
Preferred Names
cysteine-rich protein 2-binding protein
Names
ADA2A-containing complex subunit 2
ATAC component 2 homolog
CRP2 binding partner
CRP2 binding protein
CSRP2 binding protein
CSRP2-binding protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020536.4NP_065397.3  cysteine-rich protein 2-binding protein

    See identical proteins and their annotated locations for NP_065397.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and is the protein-coding transcript.
    Source sequence(s)
    AI199208, BC007537, BC009174, BQ691686, CA443252
    Consensus CDS
    CCDS13133.1
    UniProtKB/Swiss-Prot
    Q9H8E8
    Related
    ENSP00000392318, OTTHUMP00000030351, ENST00000435364, OTTHUMT00000078152
    Conserved Domains (2) summary
    cd04301
    Location:675727
    NAT_SF; N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate
    pfam13673
    Location:664751
    Acetyltransf_10; Acetyltransferase (GNAT) domain

RNA

  1. NR_028402.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' end compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI199208, AU140233, BC009174, CA443252
    Related
    ENST00000489634, OTTHUMT00000127624

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p2 Primary Assembly

    Range
    18142224..18188387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    18122862..18169027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177926.1: Suppressed sequence

    Description
    NM_177926.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.