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    THAP11 THAP domain containing 11 [ Homo sapiens (human) ]

    Gene ID: 57215, updated on 5-May-2013
    Official Symbol
    THAP11provided by HGNC
    Official Full Name
    THAP domain containing 11provided by HGNC
    Primary source
    HGNC:23194
    Locus tag
    HRIHFB2206
    See related
    Ensembl:ENSG00000168286; HPRD:11629; MIM:609119; Vega:OTTHUMG00000137546
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RONIN; CTG-B43a; CTG-B45d; HRIHFB2206
    Summary
    The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases. [provided by RefSeq, Jul 2008]
    Location :
    16q22.1
    Sequence :
    Chromosome: 16; NC_000016.9 (67876213..67878098)
    See THAP11 in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene RAN binding protein 10 Neighboring gene translin-associated factor X interacting protein 1 Neighboring gene centromere protein T Neighboring gene nuclear transport factor 2 Neighboring gene enhancer of mRNA decapping 4

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Charting the landscape of tandem BRCT domain-mediated protein interactions. Woods NT, et al. Sci Signal, 2012 Sep 18. PMID 22990118.
    2. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. Aichem A, et al. J Cell Sci, 2012 Oct 1. PMID 22797925.
    3. THAP11, a novel binding protein of PCBP1, negatively regulates CD44 alternative splicing and cell invasion in a human hepatoma cell line. Lian WX, et al. FEBS Lett, 2012 May 21. PMID 22673507.
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, et al. Mol Cell Proteomics, 2012 May. PMID 22505724.
    5. A transcriptional regulatory role of the THAP11-HCF-1 complex in colon cancer cell function. Parker JB, et al. Mol Cell Biol, 2012 May. PMID 22371484.

    See all (18) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. In HCC patients, the expression of THAP11 mRNA significantly correlated with PCBP1 mRNA expression. Our results suggest a novel role of THAP11 in CD44 alternative splicing and hepatoma invasion
      Title: THAP11, a novel binding protein of PCBP1, negatively regulates CD44 alternative splicing and cell invasion in a human hepatoma cell line.
    2. identify THAP11 as a transcriptional regulator differentially expressed in human colon cancer
      Title: A transcriptional regulatory role of the THAP11-HCF-1 complex in colon cancer cell function.
    3. the induced THAP11 might be one of transcriptional regulators of c-Myc expression in CML cell.
      Title: Down-regulation of Thanatos-associated protein 11 by BCR-ABL promotes CML cell proliferation through c-Myc expression.
    4. Results suggest that THAP11 functions as a cell growth suppressor by negatively regulating the expression of c-Myc.
      Title: Cell growth suppression by thanatos-associated protein 11(THAP11) is mediated by transcriptional downregulation of c-Myc.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:121453 BioGRID:107286 CASP3    BioGRID  PubMed Two-hybrid 
    BioGRID:121453 BioGRID:107869 CTBP1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:121453 BioGRID:108223 ECT2    BioGRID  PubMed Two-hybrid 
    BioGRID:121453 BioGRID:109304 HCFC1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid 
    BioGRID:121453 BioGRID:109315 HDAC1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:121453 BioGRID:117439 SIN3A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:121453 BioGRID:122479 SLX1B    BioGRID  PubMed Two-hybrid 
    BioGRID:121453 BioGRID:114709 SRSF11    BioGRID  PubMed Two-hybrid 
    BioGRID:121453 BioGRID:121453 THAP11    BioGRID  PubMed Reconstituted Complex 
    BioGRID:121453 BioGRID:116624 TPX2    BioGRID  PubMed Two-hybrid 
    BioGRID:121453 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121453 BioGRID:115791 UBD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121453 BioGRID:206739 Zwint    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    half bridge of spindle pole body IDA
    Inferred from Direct Assay
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    Preferred Names
    THAP domain-containing protein 11
    Names
    THAP domain-containing protein 11

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020457.2 → NP_065190.2  THAP domain-containing protein 11

      Status: REVIEWED

      Source sequence(s)
      BC012182, BI261822, BQ898449
      Consensus CDS
      CCDS10847.1
      UniProtKB/Swiss-Prot
      Q96EK4
      Related
      ENSP00000304689, OTTHUMP00000174850, ENST00000303596, OTTHUMT00000268879
      Conserved Domains (1) summary
      smart00980
      Location:6 – 81
      Blast Score: 188
      THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion.

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p10 Primary Assembly

      Range
      67876213..67878098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      53749224..53751109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018927.1 Alternate CHM1_1.0

      Range
      68882643..68884528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01025461.1 (7141..9026) None
    genomic AC040162.5 (171683..173568) None
    genomic AMYH01007753.1 (22471..24356) None
    genomic CH471092.1 EAW83180.1
    mRNA AB015338.1 BAA34796.1
    mRNA AK289367.1 BAF82056.1
    mRNA BC012182.1 AAH12182.1
    mRNA BI261822.1 None
    mRNA BQ898449.1 None
    mRNA EF036502.1 ABO65088.1
    mRNA L10378.1 None
    mRNA L10379.1 None
    other-genetic DQ892600.2 ABM83526.1
    other-genetic DQ895831.2 ABM86757.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96EK4.2 GenPept UniProtKB/Swiss-Prot:Q96EK4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

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