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    SPRYD7 SPRY domain containing 7 [ Homo sapiens ]

    Gene ID: 57213, updated on 11-May-2012
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    Summary

    Official Symbol
    SPRYD7provided by HGNC
    Official Full Name
    SPRY domain containing 7provided by HGNC
    Primary source
    HGNC:14297
    See related
    Ensembl:ENSG00000123178; HPRD:08486; MIM:607866; Vega:OTTHUMG00000016924
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLLD6; C13orf1
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    Genomic context

    Location :
    13q14
    Sequence :
    Chromosome: 13; NC_000013.10 (50486842..50510626, complement)
    See SPRYD7 in Epigenomics, MapViewer

    Chromosome 13 - NC_000013.10Genomic Context describing neighboring genes Neighboring gene karyopherin alpha 3 (importin alpha 4) Neighboring gene CTAGE family, member 10, pseudogene Neighboring gene deleted in lymphocytic leukemia 2 (non-protein coding) Neighboring gene tripartite motif containing 13 Neighboring gene potassium channel regulator Neighboring gene microRNA 16-1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.

    See all (16) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:121451 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

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    General protein information

    Preferred Names
    SPRY domain-containing protein 7
    Names
    SPRY domain-containing protein 7
    CLL deletion region gene 6 protein
    chronic lymphocytic leukemia deletion region gene 6 protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127482.1 → NP_001120954.1  SPRY domain-containing protein 7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) omits an in-frame coding exon resulting in a shorter protein isoform (2) compared to isoform 1.
      Source sequence(s)
      AF334405, AK290576, BC022519, DN992366
      Consensus CDS
      CCDS45046.1
      UniProtKB/Swiss-Prot
      Q5W111
      Related
      ENSP00000367437, ENST00000378195
      Conserved Domains (1) summary
      cl02614
      Location:36 – 132
      Blast Score: 170
      SPRY; SPRY domain

    2. NM_020456.2 → NP_065189.1  SPRY domain-containing protein 7 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the predicted full length protein isoform (1).
      Source sequence(s)
      AF334405, BC007076, DN992366
      Consensus CDS
      CCDS9422.1
      UniProtKB/Swiss-Prot
      Q5W111
      Related
      ENSP00000354774, OTTHUMP00000018428, ENST00000361840, OTTHUMT00000044942
      Conserved Domains (1) summary
      cl02614
      Location:62 – 171
      Blast Score: 210
      SPRY; SPRY domain

    RNA

    1. NR_023351.1 RNA Sequence

      Description
      Transcript Variant: This variant (3) omits two coding exons resulting in a frameshift and premature stop codon. The transcript is predicted to be a candidate for nonsense-mediated decay.
      Source sequence(s)
      AF334405, BC007076, BM828692, DA388141, DN992366

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000013.10 Reference GRCh37.p5 Primary Assembly

      Range
      50486842..50510626, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000145.1 Alternate HuRef

      Range
      31280759..31304881, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL136123.19 CAH71578.1
    genomic CH471075.1 EAX08840.1
      EAX08841.1
      EAX08842.1
      EAX08843.1
    genomic CS185647.1 CAJ42828.1
    mRNA AF052154.1 None
    mRNA AF055016.1 AAC09363.1
    mRNA AF334405.1 AAK38371.1
    mRNA AK290576.1 BAF83265.1
    mRNA AK308818.1 None
    mRNA AK316576.1 BAG38165.1
    mRNA BC007076.1 None
    mRNA BC022519.1 AAH22519.1
    mRNA BM828692.1 None
    mRNA DA388141.1 None
    mRNA DN992366.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5W111.2 GenPept UniProtKB/Swiss-Prot:Q5W111
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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