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    ACTR3B ARP3 actin-related protein 3 homolog B (yeast) [ Homo sapiens ]

    Gene ID: 57180, updated on 11-May-2012
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    Summary

    Official Symbol
    ACTR3Bprovided by HGNC
    Official Full Name
    ARP3 actin-related protein 3 homolog B (yeast)provided by HGNC
    Primary source
    HGNC:17256
    See related
    Ensembl:ENSG00000133627; HPRD:12489; Vega:OTTHUMG00000151463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARP11; ARP3BETA; DKFZp686O24114
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    Genomic context

    Location :
    7q36.1
    Sequence :
    Chromosome: 7; NC_000007.13 (152456851..152552463)
    See ACTR3B in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 2 Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 pseudogene 3 Neighboring gene dipeptidyl-peptidase 6 Neighboring gene dipeptidyl-peptidase 6

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    2. Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.
    3. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.
    5. Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells. Shindo-Okada N, et al. Biochem Biophys Res Commun, 2003 Dec 26. PMID 14651955.

    See all (10) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. Thus, overexpression of Arp11 may suppress tumorigenicity in nude mice.
      Title: Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Actin related protein 3 beta Q96IZ7 RSRC1    HPRD  PubMed  
    BioGRID:121429 BioGRID:115404 ACTR2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121429 BioGRID:115803 ARPC1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121429 BioGRID:115402 ARPC1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121429 BioGRID:115415 ARPC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121429 BioGRID:115401 ARPC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121429 BioGRID:124578 ARPC3P1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121429 BioGRID:115400 ARPC4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121429 BioGRID:115399 ARPC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121429 BioGRID:123617 ARPC5L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121429 BioGRID:107454 CDK4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121429 BioGRID:121775 KIAA1967    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121429 BioGRID:116472 TWF2    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    actin-related protein 3B
    Names
    actin-related protein 3B
    ARP3-beta
    actin-like protein 3B
    actin-related protein ARP4
    actin-related protein Arp11
    actin-related protein 3-beta
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040135.1 → NP_001035225.1  actin-related protein 3B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC072057, AC092180, DB570472
      Consensus CDS
      CCDS34782.1
      UniProtKB/Swiss-Prot
      Q9P1U1
      Related
      ENSP00000367007, OTTHUMP00000200077, ENST00000377776, OTTHUMT00000322804
      Conserved Domains (2) summary
      cd00012
      Location:7 – 317
      Blast Score: 845
      ACTIN; Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one ...
      PTZ00280
      Location:317 – 347
      Blast Score: 146
      PTZ00280; Actin-related protein 3; Provisional

    2. NM_020445.4 → NP_065178.1  actin-related protein 3B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC072057, AC092180, DB570472
      Consensus CDS
      CCDS5934.1
      UniProtKB/Swiss-Prot
      Q9P1U1
      Related
      ENSP00000256001, OTTHUMP00000200076, ENST00000256001, OTTHUMT00000322803
      Conserved Domains (2) summary
      cd00012
      Location:7 – 411
      Blast Score: 1096
      ACTIN; Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one ...
      PTZ00280
      Location:2 – 417
      Blast Score: 1871
      PTZ00280; Actin-related protein 3; Provisional

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      152456851..152552463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      146267030..146310451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      151783931..151879543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC072057.8 (46454..140149) None
    genomic AC092180.5 AAS07430.1
    genomic CH471209.1 EAW80446.1
    mRNA AB209174.1 BAD92411.1
    mRNA AF023453.1 AAC98904.1
    mRNA AF086920.1 AAP97150.1
    mRNA AK001198.1 BAG50867.1
    mRNA AK294292.1 BAG57575.1
    mRNA AK315534.1 BAG37914.1
    mRNA AK316078.1 BAH14449.1
    mRNA BC008682.1 AAH08682.1
    mRNA BC015207.1 AAH15207.1
    mRNA DB570472.1 None
    other-genetic DQ894754.2 ABM85680.1
    other-genetic EU176295.1 ABW03746.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q59GD5 GenPept UniProtKB/TrEMBL:Q59GD5
    Q75LP0 GenPept UniProtKB/TrEMBL:Q75LP0
    Q9P1U1.1 GenPept UniProtKB/Swiss-Prot:Q9P1U1
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Molecular Biology Databases
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      Supplemental Content

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