My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    CORO1B coronin, actin binding protein, 1B [ Homo sapiens ]

    Gene ID: 57175, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    CORO1Bprovided by HGNC
    Official Full Name
    coronin, actin binding protein, 1Bprovided by HGNC
    Primary source
    HGNC:2253
    See related
    Ensembl:ENSG00000172725; HPRD:16743; MIM:609849; Vega:OTTHUMG00000167775
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CORONIN-2; DKFZp762I166
    Summary
    Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM, Mar 2008]
    Help top of page

    Genomic context

    Location :
    11q13.2
    Sequence :
    Chromosome: 11; NC_000011.9 (67205518..67211263, complement)
    See CORO1B in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 kinase, 70kDa, polypeptide 2 Neighboring gene protein tyrosine phosphatase, receptor type, C-associated protein Neighboring gene G protein-coupled receptor 152 Neighboring gene calcium binding protein 4

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. Cai L, et al. Cell, 2007 Mar 9. PMID 17350576.
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Coronin 1B regulates leading edge dynamics and controls cell motility and interactions with the actin-related protein (Arp)2/3 complex
      Title: Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.
    2. Study concludes that Coronin 1B's coordination of filament formation by Arp2/3 complex and filament turnover by Cofilin is required for effective lamellipodial protrusion and cell migration.
      Title: Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge.
    3. In rabbits, cholinergic stimulation increases the phosphorylation of coronin 1B in gastric mucosal cells
      Title: Isolation, cloning, and characterization of a new mammalian coronin family member, coroninse, which is regulated within the protein kinase C signaling pathway.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9BR76 O15144 ARPC2    HPRD  PubMed  
    Q9BR76 Q9BR76 CORO1B    HPRD  PubMed  
    Q9BR76 P17252 PRKCA    HPRD  PubMed  
    Q9BR76 Slingshot 1 SSH1    HPRD  PubMed  
    BioGRID:121425 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    coronin-1B
    Names
    coronin-1B
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001018070.2 → NP_001018080.1  coronin-1B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC006449, DA061767
      Consensus CDS
      CCDS8164.1
      UniProtKB/Swiss-Prot
      Q9BR76
      Related
      ENSP00000377471, ENST00000393893
      Conserved Domains (4) summary
      pfam08953
      Location:5 – 69
      Blast Score: 354
      DUF1899; Domain of unknown function (DUF1899)
      pfam08954
      Location:258 – 392
      Blast Score: 595
      DUF1900; Domain of unknown function (DUF1900)
      PTZ00421
      Location:10 – 485
      Blast Score: 818
      PTZ00421; coronin; Provisional
      cl02567
      Location:77 – 297
      Blast Score: 264
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_020441.2 → NP_065174.1  coronin-1B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AP003419, BC006449
      Consensus CDS
      CCDS8164.1
      UniProtKB/Swiss-Prot
      Q9BR76
      Related
      ENSP00000340211, OTTHUMP00000236823, ENST00000341356, OTTHUMT00000396220
      Conserved Domains (4) summary
      pfam08953
      Location:5 – 69
      Blast Score: 354
      DUF1899; Domain of unknown function (DUF1899)
      pfam08954
      Location:258 – 392
      Blast Score: 595
      DUF1900; Domain of unknown function (DUF1900)
      PTZ00421
      Location:10 – 485
      Blast Score: 818
      PTZ00421; coronin; Provisional
      cl02567
      Location:77 – 297
      Blast Score: 264
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      67205518..67211263, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      63533695..63539440, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AP003419.3 (118510..124255) None
    genomic CH471076.1 EAW74623.1
      EAW74624.1
      EAW74625.1
      EAW74626.1
    mRNA AK000860.1 None
    mRNA AK295782.1 BAG58604.1
    mRNA AK309267.1 None
    mRNA AK315399.1 BAG37792.1
    mRNA AL162072.1 CAB82408.1
    mRNA BC006449.1 AAH06449.1
    mRNA BI767141.1 None
    mRNA DA061767.1 None
    other-genetic DQ893397.2 ABM84323.1
    other-genetic DQ896718.2 ABM87717.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q59F81 GenPept UniProtKB/TrEMBL:Q59F81
    Q9BR76.1 GenPept UniProtKB/Swiss-Prot:Q9BR76
    Q9NSK3 GenPept UniProtKB/TrEMBL:Q9NSK3
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...