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    TRIM54 tripartite motif containing 54 [ Homo sapiens ]

    Gene ID: 57159, updated on 11-May-2012

    Summary

    Official Symbol
    TRIM54provided by HGNC
    Official Full Name
    tripartite motif containing 54provided by HGNC
    Primary source
    HGNC:16008
    See related
    Ensembl:ENSG00000138100; HPRD:05928; MIM:606474; Vega:OTTHUMG00000097078
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MURF; RNF30; muRF3; MURF-3
    Summary
    The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    2p23.3
    Sequence :
    Chromosome: 2; NC_000002.11 (27505297..27530307)
    See TRIM54 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 30 (zinc transporter), member 3 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 5 gamma Neighboring gene MpV17 mitochondrial inner membrane protein Neighboring gene urocortin Neighboring gene general transcription factor IIIC, polypeptide 2, beta 110kDa Neighboring gene uncharacterized LOC100505624

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9BYV2 Q9BYV6 TRIM55    HPRD  PubMed  
    Q9BYV2 Q969Q1 TRIM63    HPRD  PubMed  
    BioGRID:121415 BioGRID:112221 ATXN7    BioGRID  PubMed Two-hybrid 
    BioGRID:121415 BioGRID:124195 TRIM63    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:121415 BioGRID:113164 UBC    BioGRID  PubMed Reconstituted Complex 
    BioGRID:121415 BioGRID:113177 UBE2I    BioGRID  PubMed Two-hybrid 
    BioGRID:121415 BioGRID:127156 UBE2U    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    signal transducer activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    zinc ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule-based process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of microtubule depolymerization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    tripartite motif-containing protein 54
    Names
    tripartite motif-containing protein 54
    ring finger protein 30
    tripartite motif-containing 54
    muscle-specific RING finger protein 3
    muscle-specific RING-finger protein 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032546.3NP_115935.3  tripartite motif-containing protein 54 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AJ291714, BC141807, CA423735, DA897004
      Consensus CDS
      CCDS1745.2
      UniProtKB/Swiss-Prot
      Q9BYV2
      Related
      ENSP00000296098, OTTHUMP00000122597, ENST00000296098, OTTHUMT00000214198
      Conserved Domains (2) summary
      cd00162
      Location:2685
      Blast Score: 107
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam13923
      Location:2283
      Blast Score: 116
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
    2. NM_187841.2NP_912730.2  tripartite motif-containing protein 54 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment within the coding region. The resulting shorter isoform (2) lacks an internal region, as compared to isoform 1.
      Source sequence(s)
      BC141807, CA423735, DA897004
      Consensus CDS
      CCDS1746.2
      UniProtKB/Swiss-Prot
      Q9BYV2
      Related
      ENSP00000369415, OTTHUMP00000122598, ENST00000380075, OTTHUMT00000214199
      Conserved Domains (2) summary
      cd00162
      Location:2685
      Blast Score: 108
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam13923
      Location:2283
      Blast Score: 117
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      27505297..27530307
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      27247000..27272529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC013413.6 AAY24296.1
    genomic CH471053.2 EAX00606.1
      EAX00607.1
    mRNA AJ291714.1 CAC32841.1
      CAC32842.1
    mRNA AK300699.1 BAG62380.1
    mRNA BC141807.1 AAI41808.1
    mRNA BF829678.1 None
    mRNA BU633919.1 None
    mRNA CA423735.1 None
    mRNA DA897004.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BYV2.3 GenPept UniProtKB/Swiss-Prot:Q9BYV2

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