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SLURP1 secreted LY6/PLAUR domain containing 1 [ Homo sapiens (human) ]

Gene ID: 57152, updated on 17-Jul-2016
Official Symbol
SLURP1provided by HGNC
Official Full Name
secreted LY6/PLAUR domain containing 1provided by HGNC
Primary source
HGNC:HGNC:18746
See related
Ensembl:ENSG00000126233 HPRD:05836; MIM:606119; Vega:OTTHUMG00000164685
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARS; MDM; ANUP; ArsB; LY6LS
Summary
The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008]
Orthologs
Location:
8q24.3
Exon count:
3
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (142740944..142742411, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143822362..143823829, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100288181 Neighboring gene lymphocyte antigen 6 complex, locus K Neighboring gene thioesterase superfamily member 6 Neighboring gene LY6/PLAUR domain containing 2 Neighboring gene Ly6/neurotoxin 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell activation IBA
Inferred from Biological aspect of Ancestor
more info
 
cell activation NAS
Non-traceable Author Statement
more info
PubMed 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
negative regulation of keratinocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
neuromuscular process controlling posture IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
secreted Ly-6/uPAR-related protein 1
Names
ARS(component B)-81/S
SLURP-1
anti-neoplastic urinary protein
lymphocyte antigen 6-like secreted
secreted Ly6/uPAR related protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011494.1 RefSeqGene

    Range
    5001..6468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_020427.2NP_065160.1  secreted Ly-6/uPAR-related protein 1 precursor

    See identical proteins and their annotated locations for NP_065160.1

    Status: REVIEWED

    Source sequence(s)
    X99977
    Consensus CDS
    CCDS6387.1
    UniProtKB/Swiss-Prot
    P55000
    Related
    ENSP00000246515, OTTHUMP00000227216, ENST00000246515, OTTHUMT00000379741
    Conserved Domains (1) summary
    cd00117
    Location:23101
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

    Range
    142740944..142742411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    143862635..143864102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)