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    SCYL3 SCY1-like 3 (S. cerevisiae) [ Homo sapiens ]

    Gene ID: 57147, updated on 11-May-2012
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    Summary

    Official Symbol
    SCYL3provided by HGNC
    Official Full Name
    SCY1-like 3 (S. cerevisiae)provided by HGNC
    Primary source
    HGNC:19285
    See related
    Ensembl:ENSG00000000457; HPRD:07459; MIM:608192; Vega:OTTHUMG00000035941
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PACE1; PACE-1; RP1-97P20.2
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    Genomic context

    Location :
    1q24.2
    Sequence :
    Chromosome: 1; NC_000001.10 (169821804..169863076, complement)
    See SCYL3 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene selectin E Neighboring gene chromosome 1 open reading frame 112 Neighboring gene methyltransferase like 18 Neighboring gene kinesin-associated protein 3 Neighboring gene mitochondrial ribosomal protein S10 pseudogene 1 Neighboring gene sialic acid binding Ig-like lectin 30, pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    5. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. Cheung CL, et al. Hum Mol Genet, 2009 Feb 15. PMID 19064610.

    See all (15) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q8IZE3 P15311 EZR    HPRD  PubMed  
    BioGRID:121404 BioGRID:113271 EZR    BioGRID  PubMed Two-hybrid 
    BioGRID:121404 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell migration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    protein-associating with the carboxyl-terminal domain of ezrin
    Names
    protein-associating with the carboxyl-terminal domain of ezrin
    SCY1-like protein 3
    ezrin-binding protein PACE-1
    ezrin-binding partner PACE-1 (PACE-1)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020423.5 → NP_065156.5  protein-associating with the carboxyl-terminal domain of ezrin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AA844031, AL117233, BC014662, DB285397
      Consensus CDS
      CCDS1286.1
      UniProtKB/Swiss-Prot
      Q8IZE3
      Related
      ENSP00000356745, OTTHUMP00000034140, ENST00000367771, OTTHUMT00000087548
      Conserved Domains (2) summary
      pfam00069
      Location:26 – 245
      Blast Score: 132
      Pkinase; Protein kinase domain
      cl09925
      Location:31 – 242
      Blast Score: 142
      PKc_like; Protein Kinases, catalytic domain

    2. NM_181093.2 → NP_851607.2  protein-associating with the carboxyl-terminal domain of ezrin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA844031, AK292507, AL117233, BC014662, DB285397
      Consensus CDS
      CCDS1287.1
      UniProtKB/Swiss-Prot
      Q8IZE3
      Related
      ENSP00000356746, ENST00000367772
      Conserved Domains (2) summary
      pfam00069
      Location:26 – 245
      Blast Score: 132
      Pkinase; Protein kinase domain
      cl09925
      Location:31 – 242
      Blast Score: 141
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      169821804..169863076, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      141044316..141085585, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL031297.4 CAB52564.2
      CAI23517.1
      CAI23518.1
    genomic CH471067.1 EAW90867.1
      EAW90868.1
    mRNA AA844031.1 None
    mRNA AF540957.1 AAN23123.1
    mRNA AK292507.1 BAF85196.1
    mRNA AK304481.1 BAG65292.1
    mRNA AL117233.1 CAB55300.1
    mRNA AY144493.1 AAN41656.1
    mRNA BC014662.1 AAH14662.1
    mRNA BX647352.1 None
    mRNA DB285397.1 None
    other-genetic AM393842.1 CAL38717.1
    other-genetic DQ893468.2 ABM84394.1
    other-genetic DQ896344.2 ABM87343.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZE3.3 GenPept UniProtKB/Swiss-Prot:Q8IZE3
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
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