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SCYL3 SCY1 like pseudokinase 3 [ Homo sapiens (human) ]

Gene ID: 57147, updated on 8-May-2016
Official Symbol
SCYL3provided by HGNC
Official Full Name
SCY1 like pseudokinase 3provided by HGNC
Primary source
HGNC:HGNC:19285
See related
Ensembl:ENSG00000000457 HPRD:07459; MIM:608192; Vega:OTTHUMG00000035941
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PACE1; PACE-1
Summary
This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]
Orthologs
Location:
1q24.2
Exon count:
16
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (169853074..169894267, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (169822215..169863100, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928628 Neighboring gene chromosome 1 open reading frame 112 Neighboring gene methyltransferase like 18 Neighboring gene uncharacterized LOC105371607 Neighboring gene kinesin associated protein 3 Neighboring gene mitochondrial ribosomal protein S10 pseudogene 1 Neighboring gene uncharacterized LOC105371608

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NOT kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell migration NAS
Non-traceable Author Statement
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
protein-associating with the carboxyl-terminal domain of ezrin
Names
SCY1-like 3
SCY1-like protein 3
SCY1-like, kinase-like 3
ezrin-binding partner PACE-1 (PACE-1)
ezrin-binding protein PACE-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020423.6NP_065156.5  protein-associating with the carboxyl-terminal domain of ezrin isoform 1

    See identical proteins and their annotated locations for NP_065156.5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AL117233, DA449356
    Consensus CDS
    CCDS1286.1
    UniProtKB/Swiss-Prot
    Q8IZE3
    Related
    ENSP00000356745, OTTHUMP00000034140, ENST00000367771, OTTHUMT00000087548
    Conserved Domains (3) summary
    pfam00069
    Location:26245
    Pkinase; Protein kinase domain
    pfam07548
    Location:368489
    ChlamPMP_M; Chlamydia polymorphic membrane protein middle domain
    cd14011
    Location:9247
    PK_SCY1_like; Pseudokinase domain of Scy1-like proteins
  2. NM_181093.3NP_851607.2  protein-associating with the carboxyl-terminal domain of ezrin isoform 2

    See identical proteins and their annotated locations for NP_851607.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2, which is longer than isoform 1.
    Source sequence(s)
    AK292507, AL117233, DA449356
    Consensus CDS
    CCDS1287.1
    UniProtKB/Swiss-Prot
    Q8IZE3
    Related
    ENSP00000356746, ENST00000367772
    Conserved Domains (2) summary
    pfam00069
    Location:26245
    Pkinase; Protein kinase domain
    cd14011
    Location:9247
    PK_SCY1_like; Pseudokinase domain of Scy1-like proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    169853074..169894267 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509801.1XP_011508103.1  

    See identical proteins and their annotated locations for XP_011508103.1

    UniProtKB/Swiss-Prot
    Q8IZE3
    Conserved Domains (2) summary
    pfam00069
    Location:26245
    Pkinase; Protein kinase domain
    cd14011
    Location:9247
    PK_SCY1_like; Pseudokinase domain of Scy1-like proteins
  2. XM_011509802.1XP_011508104.1  

    See identical proteins and their annotated locations for XP_011508104.1

    Conserved Domains (1) summary
    cl21453
    Location:1105
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006711465.1XP_006711528.1  

    See identical proteins and their annotated locations for XP_006711528.1

    UniProtKB/Swiss-Prot
    Q8IZE3
    Related
    ENSP00000356744, OTTHUMP00000034142, ENST00000367770, OTTHUMT00000087550
    Conserved Domains (2) summary
    pfam00069
    Location:26245
    Pkinase; Protein kinase domain
    cd14011
    Location:9247
    PK_SCY1_like; Pseudokinase domain of Scy1-like proteins
  4. XM_011509803.1XP_011508105.1  

    See identical proteins and their annotated locations for XP_011508105.1

    Conserved Domains (1) summary
    cl21453
    Location:1105
    PKc_like; Protein Kinases, catalytic domain
  5. XM_006711467.2XP_006711530.1  

    Conserved Domains (2) summary
    pfam00069
    Location:26245
    Pkinase; Protein kinase domain
    cl21453
    Location:9247
    PKc_like; Protein Kinases, catalytic domain

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    171244369..171285280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)